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Bil Clemons @profbilc.bsky.social · 13/07/2026

I'm excited to announce a new preprint from the lab just posted to bioRxiv: “Retrograde trafficking inhibitors allosterically trap Get3 to block tail-anchored protein biogenesis.” www.biorxiv.org/content/10.6...

The structure of Human Get3 with the inhibitor Retro-2 bound in complex with Get4.

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Reposted by Bil Clemons

Biohub @biohub.org · 25/02/2026

🧵Antibiotic resistance is a public health crisis. But viruses called phages have been solving this problem for millennia. New research in @nature.com reveals how 3 different phages attack the same weak spot—a protein called MurJt—potentially leading to a new class of antibiotics.

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Bil Clemons @profbilc.bsky.social · 25/03/2025

A new paper from our lab is available at doi.org/10.1101/2025.... The work describes how ArsA, which is involved in arsenic detoxification, utilizes nucleotides to drive dramatic conformational changes—multiple EM structures of a 64kDa protein. Congratulations to Shivansh Mahajan.

doi.org

Nucleotide and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA

A common mechanism of arsenic detoxification in bacteria is arsenite (AsIII) efflux facilitated by the ArsAB pump that couples metalloid transport to ATP hydrolysis. The cytoplasmic ATPase component, ...

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Bil Clemons @profbilc.bsky.social · 05/12/2024

It was a fun day. Thanks everyone!

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Reposted by Bil Clemons

Anirban Banerjee @banirbn.bsky.social · 05/12/2024

A privilege to host Bil Clemons @profbilc.bsky.social at the NIH Intramural Program for the Wednesday Afternoon Lecture Series. A fantastic talk about how phages use proteins to target bacterial cell wall biosynthesis machinery and a truly insightful lesson about inequity in science and society.

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