Nature Neuroscience - The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These...

The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...

PIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t…

Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...

Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...

Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the β-globin gene, is characterized by sickle erythrocytes that are ...

Opening of the NMDA receptor involves bending of the helices lining the ion channel gate.

Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...

Nature, Published online: 16 September 2025; doi:10.1038/s41586-025-09610-x Delta-type glutamate receptors are ligand-gated ion channels

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

Proprioceptive group Ia afferents detect muscle stretch to guide effortless and purposeful movement and make monosynaptic connections with spinal α–motor neurons to mediate reflexes, such as the stret...

Gangwar et al. present cryo-electron microscopy structures of GluK2 kainate receptors with auxiliary subunit Neto2 and reveal the basis of receptor activation.

Whether or not Congress cuts NIH’s budget, the Trump administration has devastated its ability to operate.

American science and innovation should not be subject to the political winds of the day. Find out how the Trump administration’s grant terminations are affecting your school, your community, and your ...

Processing EMPIAR-10256 with a focus on handling pseudosymmetry and 3D Classification parameter choices.

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Excitatory synaptic transmission in the human nervous system is mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), tetrameric ligand-gated ion channels localized in t...

Nature - Gating and noelin clustering of native Ca2+-permeable AMPA receptors

A clinically available AMPAR antagonist inhibits T cell egress from lymph nodes and shows therapeutic effects in mouse models of multiple sclerosis.

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YouTube video by Senator Chris Van Hollen

Federal officials said Harvard must enact “merit-based reform” in hiring and admissions, among other things. Harvard called the demands unlawful.