Inhaling cold air triggers adipose tissue thermogenesis. In this issue of Developmental Cell, Jiang et al. utilized the cold exposure to lung only (CELO) system to demonstrate that cold air activates ...

While cold exposure is known to stimulate thermogenesis, the contribution of the lung to this process remains unclear. This study identifies a pulmonary pathway that enhances Irisin production and adi...

Protein phosphorylation is dynamically regulated by the opposing activities of phosphowriter enzymes (kinases) and phosphoeraser enzymes (phosphata...

James’s research in the Simcox Lab explored the role certain lipids play in energy expenditure.

Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched-chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with...

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Neutralizing leptin reduces inflammation and fibrosis in mice, suggesting a potential treatment for fibrotic diseases.

Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in ...

Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...

Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...

The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

Spring brought abundant blossoms, greening of the prairie, songs of migratory birds, and many volunteer groups active on the land. In just thirteen weeks, nine different organizations carried out serv...

Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

Attie, a dedicated mentor and educator, has devoted his career to advancing our knowledge of diabetes and metabolism.

Stearoyl-CoA desaturase-1 (SCD1) is a critical regulator of lipogenesis that catalyzes the synthesis of MUFAs, mainly oleate (18:1n-9) and palmitoleate (16:1n-7) from saturated fatty acids, stearoyl-C...

Research from the Ntambi and Simcox Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies.

Graduate student Gina Wade received the Denton Award and postdoctoral researcher Jericha Mill received the Leirmo Memorial Award.

Researchers in the Simcox Lab identified an enzyme that helps to break down lipids that control energy expenditure.

Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...

Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...

Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...