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Malachi Griffith

@malachigriffith.bsky.social
180 followers 328 following 22 posts

Professor, Department of Medicine and McDonell Genome Institute @ Washington University. Specializing in Bioinformatics, Genomics, and Cancer. griffithlab.org

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Malachi Griffith @malachigriffith.bsky.social · 27/05/2026
There are still spaces available for this upcoming CBW workshop focusing on transcriptome analysis (but also acting as a general introduction to bioinformatics analysis). bioinformatics.ca/workshops-al.... Check it out and join us!
bioinformatics.ca
(2026) RNA-seq Analysis: Toronto, ON - Bioinformatics.ca
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Malachi Griffith @malachigriffith.bsky.social · 03/03/2026
ClinGen Somatic & CIViC training sessions led by Jason Saliba are coming up in March and April. If you are interested to become involved in the Clinical Genome Resource and our efforts to support precision oncology through variant classification, please apply here: ccdb.clinicalgenome.org/apply
ccdb.clinicalgenome.org
CCDB
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Malachi Griffith @malachigriffith.bsky.social · 13/01/2026
Came across this paper as the source of an evidence submission in CIViC for clinical significance of V600 mutation in secondary histiocytic sarcoma. A couple things stood out. First, that they report ("Mutation in exon 15 of BRAF V600 (V600E, V600K and V600R) was detected") doi.org/10.1186/s128....
doi.org
Client Challenge
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Malachi Griffith @malachigriffith.bsky.social · 07/01/2026
A nice paper that acts as a great exemplar for curation of clinical variant information in CIViC (civicdb.org). www.nature.com/articles/s41.... The authors report on a clinical trial (evaluating the menin inhibitor revumenib in acute leukemia).
nature.com
MEN1 mutations mediate clinical resistance to menin inhibition - Nature
Somatic mutations in MEN1 are identified in patients with leukaemia treated with a novel chromatin-targeting therapy, and the mechanism by which these mutations mediate therapeutic resistance&nbs...
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Reposted by Malachi Griffith
Abraham Palmer @abepalmer.bsky.social · 06/01/2026
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch. IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE. Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
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Reposted by Malachi Griffith
Alex Wagner @alexphd.bsky.social · 19/12/2025
Help the DGIdb development team understand how we can better promote hypothesis generation and interaction data sets for the biomedical and clinical research community. Take 5 minutes to share how you use DGIdb and what we can improve for your research: forms.gle/ohrk49dmHMPX...
forms.gle
DGIdb Feature Sets Evaluation
Below is a list of proposed features currently under consideration for inclusion in the next major release of DGIdb. Each feature is grouped by category and includes a brief description. We ask that y...
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Reposted by Malachi Griffith
itcrtraining.bsky.social @itcrtraining.bsky.social · 18/11/2025
The ITCR Training Network (ITN) www.itcrtraining.org develops training materials for informatics and research. We have a short survey ~3-9 min about your experience & preferences for learning as a researcher. Previous engagement not required! xiar7j-itn.shinyapps.io/itn_follow_up/
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Reposted by Malachi Griffith
Rafael Irizarry @rafalab.bsky.social · 01/12/2025
📢 We are taking applications for our Postdoctoral Fellows Program at Harvard/DFCI! 🔹Join a research group in our department 🔹Co-mentoring opportunities with 2+ faculty 🔹Collaborate with investigators beyond our department 🔹Salary starts at $75K Apply here: t.co/B7SLZzQFKu
t.co
https://ds.dfci.harvard.edu/postdocs/
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Reposted by Malachi Griffith
Global Alliance for Genomics and Health @ga4gh.org · 01/12/2025
GA4GH April Connect 2026 registration and session proposal submissions are now open! The meeting will take place from 14 to 17 April 2026 in Montreal, Canada. We invite the GA4GH community to submit session proposals by 30 January. Learn more: broadinstitute.swoogo.com/connect26/10...
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Malachi Griffith @malachigriffith.bsky.social · 01/12/2025
Excited to announce that we will be delivering a Canadian Bioinformatics Workshop (CBW) covering RNA-seq analysis and general bioinformatics this summer in Toronto. Hosted by Ontario Institute for Cancer Research (OICR). bioinformatics.ca/workshops-al...
bioinformatics.ca
(2026) RNA-seq Analysis: Toronto, ON - Bioinformatics.ca
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Malachi Griffith @malachigriffith.bsky.social · 24/11/2025
The open access resource CIViCdb.org (Clinical Interpretation of Variants in Cancer) has just passed 11,000 evidence statements! That's 11k times a domain expert reviewed a paper and used the CIViC curation interface to create a structured entry for clinical relevance of a specific somatic variant.
civicdb.org
CIViC - Clinical Interpretation of Variants in Cancer
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Reposted by Malachi Griffith
Genome in a Bottle Consortium @genomeinabottle.bsky.social · 20/12/2024
Our first curated draft somatic structural variant benchmark for the new GIAB PDAC tumor cell line HG008-T is at ftp-trace.ncbi.nlm.nih.gov/ReferenceSam..., based on extensive short+long read sequencing data described in doi.org/10.1101/2024.... Feedback to improve future versions is very welcome!
ftp-trace.ncbi.nlm.nih.gov
Index of /ReferenceSamples/giab/data_somatic/HG008/Liss_lab/analysis/NIST_HG008-T_somatic-stvar_DraftBenchmark_V0.1-20241219
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