The FDA agreed to speed its review of a Roche drug the developer says could be the first oral high-efficacy therapy approved for two MS types.

Although the cause of multiple sclerosis (MS) is unclear, infectious agents, including some parasitic roundworms (nematodes), have been proposed as possible risk factors or contributors. Here, we cond...

Neurologia i Neurochirurgia Polska

Experts in Nottingham who helped developed the test hope it will be rolled out across the country.

YouTube video by Dr. Brandon Beaber

YouTube video by Dr. Brandon Beaber

Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Here, we use AQP4 gene expression to reconstruct a whole-brain glymphatic-rel...

YouTube video by Dr. Brandon Beaber

I am a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system, and I post new videos about MS every Wednesday Check out my...

Progressive multiple sclerosis (MS) remains a major therapeutic challenge because disability often continues to accumulate despite effective control of relapses and new focal inflammatory lesions. This dissociation suggests that progression is driven not only by acute inflammation, but also by a dis …

YouTube video by Dr. Brandon Beaber

YouTube video by Dr. Brandon Beaber

In this large real-world cohort, high-grade LON (grades 3-4) events were rare and frequently complicated by infections. Mild (grade 2) LON events were often fluctuating and generally clinically uneventful. Rechallenge with rituximab was rarely complicated by serious adverse events. Prediction of LON …

Stiff-person syndrome is a disabling central nervous system disorder with no satisfactory treatment that is characterized by muscle rigidity, episodic muscle spasms, high titers of antibodies again...

YouTube video by Aaron Boster MD

Background Management of multiple sclerosis (MS) during pregnancy requires balancing maternal disease control with fetal safety. Among high-efficacy disease-modifying therapies, anti-CD20 monoclonal a...

Background and purpose Oligoclonal band (OCB) positivity is a well-established biomarker in multiple sclerosis (MS), yet the clinical and radiological relevance of OCB count remains unclear. Although ...

PRL are associated with subsequent radiological activity in pre-symptomatic MS, featuring complementary predictive value beyond biomarkers currently included in the 2024 McDonald criteria.

Background and ObjectivesProspective multinational studies integrating imaging and soluble biomarkers in early multiple sclerosis (MS) are limited. The MultipleMS study compared 2-year clinical, radiologic, and biomarker outcomes across disease-modifying ...

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Intravenous methylprednisolone pulse therapy administered for asymptomatic gadolinium-enhancing lesions was not associated with a statistically significant reduction in the formation of chronic T1 black holes over a 6-month follow-up period.

YouTube video by Dr. Brandon Beaber

Obesity at diagnosis was associated with worse disability outcomes primarily among individuals lacking HLA-A*02:01, suggesting that HLA class I-related immune pathways may modify the influence of excess adiposity on MS disease progression.

The most exciting developments in MS, is the use of engineered T-cells, or chimeric antigen receptor (CAR) T-cells, as a treatment. A new study takes this treatment to the next phase.

C-sections <39 weeks were more common in pregnant women with multiple sclerosis but were attributable to standard obstetric indications rather than multiple sclerosis. Documentation of multiple sclerosis as a pregnancy complication suggests persistent provider misconceptions.

YouTube video by Dr. Brandon Beaber

Ad hoc announcement pursuant to Art. 53 LR    REMODEL-1/-2 trials met their primary endpoint, significantly reducing annualized relapse rate (ARR) vs...

Background Fifteen regional studies published over the last six decades surveying prevalence, mortality and hospital admissions have suggested that Scotland is amongst the highest risk nations for mul...

The FDA has cleared Quantum BioPharma's investigational new drug application for Lucid-MS, allowing the company to begin a phase 2 trial of the first-in-class demyelination-targeting compound in progr...

Incidence of MS has been steadily increasing in the city of Catania, reaching a peak in 2015-2019 confirming Catania as one of the highest-incidence areas in Italy. Additionally, we observed an increasing age at onset for both sexes, which may be attributable to improved diagnosis of late-onset MS c …

YouTube video by Aaron Boster MD

YouTube video by Dr. Brandon Beaber

Hearing problems are quite common in people with MS; they often have problems hearing in noisy environments, i.e. following a conversation when there is a lot of other background noise. Do you?