iiinova — where your digital self keeps evolving

Reposted by Linley Sherin

Judith Mank @judithmank.bsky.social · 23/09/2026

So very, very happy to see this out @plosbiology.org : Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations. Beautiful work by two very clever and talented coauthors, Yuying Lin and @vdbijl.bsky.social . journals.plos.org/plosbiology/... 1/

journals.plos.org

Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations

Genomic inversions spanning many genes can persist for millions of years. This study of Trinidadian guppy populations reveals how both ecological conditions and mate choice help maintain this hidden l...

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Reposted by Linley Sherin

Judith Mank @judithmank.bsky.social · 17/08/2026

Long-reads reveal 6X more guppy genes are sex-biased for splicing compared to short-reads. But male isoform richness mostly reflects transcriptional noise, not proteomic expansion. Beautiful analysis by @linley-sherin.bsky.social out now doi.org/10.64898/202...

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Linley Sherin @linley-sherin.bsky.social · 15/08/2026

🚨My first PhD chapter is now out on bioRxiv ! A 🧵 1/n

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Reposted by Linley Sherin

Joelle Lafond, PhD @joellelafond.bsky.social · 27/04/2026

🚨 My very first postdoc paper is out! 🐠 We show that the Y chromosome of the swamp guppy (Poecilia picta) has rapidly degenerated, losing genes, shrinking, and filling up with transposable elements, while the X responds by exporting key male genes to autosomes. 🧵⬇️ 1/6 📷Joëlle Lafond

Figure showing the paper's title: Structural and Functional Divergence of the Poecilia picta Sex Chromosomes.

It includes artistic drawing of the male fish of this study, Poecilia picta, on a background with DNA helixes.

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Linley Sherin @linley-sherin.bsky.social · 03/04/2026

Very excited to announce our new review accepted at Phil. Trans. B. (in press)! This project started after a journal club I presented this time last year (!) sparked some lab discussions and it's been so much fun seeing it become a paper. Big thanks to all my co-authors for making it happen :)

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Reposted by Linley Sherin

Judith Mank @judithmank.bsky.social · 20/11/2025

Team fish - we need your help! We are trying to build a database of all the fish chromosome-scale genomes where sex chromosomes have been identified. Have you build one or some? Do you know someone who has? Can you post the link in the comments? Please spread the word and repost! Thank you!

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Reposted by Linley Sherin

Genetics Society of America @genetics-gsa.bsky.social · 26/09/2025

📢 NEW GENOME ALERT In #G3journal, @squarehare.bsky.social, @judithmank.bsky.social, and team generated a genome assembly of the Amazon guppy, Poecilia bifurca and showed how this species shares sex chromosomes with related species, albeit with substantial Y chromosome degeneration. buff.ly/lM7etkw

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Reposted by Linley Sherin

Manuel Irimia @mirimiam.bsky.social · 18/03/2025

"The main fates after gene duplication are gene loss, redundancy, subfunctionalization and neofunctionalization". In our new review, @fedemantica.bsky.social and I argue we are missing the most prevalent one: specialization. And the same applies to alternative splicing! 1/7 tinyurl.com/45k7kbmp

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Reposted by Linley Sherin

carriezhu.bsky.social @carriezhu.bsky.social · 06/08/2025

1/13 In a new preprint, we (with @xliaoyi.bsky.social‬ in the ‪@arbelharpak.bsky.social‬ lab) find that expression from the “inactivated” X (Xi) is consequential for both female-male differences in gene expression and variation among females in disease and physiology: www.biorxiv.org/content/10.1...

biorxiv.org

Escape from X inactivation drives sex differences and female trait variation

X chromosome inactivation (XCI) partially balances gene dosage between sexes, yet expression from the inactive X (Xi) is variable across genes. In this study, we investigate whether gene-level Xi expr...

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Reposted by Linley Sherin

Asad Hasan @asadh.bsky.social · 08/08/2025

Excited to finally have the pre-print up for this work on evolutionary rescue from my PhD at UBC! Previous theoretical work on the effects of negative density-dependent growth on evolutionary rescue has uncovered inconsistent results, leading to an incomplete understanding of its influence.

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Linley Sherin @linley-sherin.bsky.social · 01/07/2025

So happy to share that our paper on guppy colour pattern is out in @natecoevo.nature.com ! Click below for the 🧵 from first author and guppy phenotyping king @vdbijl.bsky.social

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Reposted by Linley Sherin

Judith Mank @judithmank.bsky.social · 28/11/2024

Recent studies have revealed unexpected Y chromosome diversity and suggest that the Y may play a big role in evolution. @vdbijl.bsky.social and I wrote this perspective for @evolletters.bsky.social with a few suggestions and requests. academic.oup.com/evlett/advan... Figs by www.jacelyndesigns.com

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