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Kate (Kathryn) Lawrence

@itskatelawrence.bsky.social

Stanford Genetics PhD Candidate MIT Physics 2020 I also ride bikes

Kate (Kathryn) Lawrence @itskatelawrence.bsky.social · 23/03/2026

It's out! I hope this work encourages folks to move beyond a standard "one variant, one gene" QTL paradigm and consider proxitropic variant effects. Big thanks to the reviewers and editors at @ajhgnews.bsky.social for their help! @sbmontgom.bsky.social www.sciencedirect.com/science/arti...

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Kate (Kathryn) Lawrence @itskatelawrence.bsky.social · 08/06/2025

Excited to share my first PhD paper in the @sbmontgom.bsky.social lab with @tamigj.bsky.social (www.biorxiv.org/content/10.1...)! Standard QTL methods treat each gene independently. But what if a single variant regulates multiple nearby genes at once - what we call “allelic proxitropy”? 🧵 ⬇️

Standard methods are equivalent to a flashlight, looking at each gene independently. We combine signals from multiple genes, turning a floodlight onto the genome.

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