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Ahmed Elfarargi

@ahmedelfarargi.bsky.social
88 followers 159 following 15 posts

Postdoc fellow @UT_AUSTIN | Evolutionary genomics | Local adaptation | Population genetics | Plant stress | Alumnus @MPIPZ_KÖLN @WUR

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Reposted by Ahmed Elfarargi
Nature Plants @natplants.nature.com · 04/08/2026
New OA Article: "A VIM2/4 deletion, and premature truncations of CMT2 and FBX5, drive DNA methylation changes after colonization of a novel habitat" rdcu.be/fxOCc Cape Verde Arabidopsis rapidly evolved altered DNA methylation patterns through high-impact mutations. #PlantScience
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 28/04/2026
Our new paper is officially out in @newphyt.bsky.social! We disentangle how plants balance the trade-offs between rapid growth and water conservation. We found that Cape Verde Arabidopsis use a highly coordinated drought escape strategy driven by pleiotropic genes.
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 10/02/2025
Museum genomics reveals temporal genetic stasis and global genetic diversity in Arabidopsis thaliana
biorxiv.org
Museum genomics reveals temporal genetic stasis and global genetic diversity in Arabidopsis thaliana
Global patterns of population genetic variation through time offer a window into evolutionary processes that maintain diversity. Over time, lineages may expand or contract their distribution, causing ...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 09/02/2025
Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae
biorxiv.org
Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae
As organisms adapt to environmental changes, natural selection modifies the frequency of non-neutral alleles. For beneficial mutations, the outcome of this process may be a selective sweep, in which a...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 10/01/2025
Quickdraws: a GWAS method to perform scalable association testing for quantiative and binary traits, without compromising computational efficiency
nature.com
A scalable variational inference approach for increased mixed-model association power - Nature Genetics
Quickdraws is a mixed-model association tool with a noninfinitesimal prior for analyzing binary and quantitative traits, using a scalable variational inference that allows analysis of biobank-scale co...
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Reposted by Ahmed Elfarargi
Sebastian Soyk @sebastiansoyk.bsky.social · 04/01/2025
Very happy to see our work on deleterious mutations in #tomato published in @naturegenet.bsky.social 🧬🌱🍅! We identify deleterious mutations that were enriched during #domestication and apply #CRISPR to repair a mutation in cultivated tomato. #genetics #plantscience www.nature.com/articles/s41...
nature.com
Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing - Nature Genetics
A deleterious mutation in the tomato transcription factor SSP2 was enriched during domestication. Repairing the deleterious mutation in cultivated tomato by base editing leads to compact growth and ea...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 06/01/2025
A rare dominant allele DYSOC1 determines seed coat color and improves seed oil content in Brassica napus
science.org
A rare dominant allele DYSOC1 determines seed coat color and improves seed oil content in Brassica napus
A rare dominant yellow SCC allele in B. napus was identified, which significantly increased SOC and decreased SLC simultaneously.
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 06/01/2025
A DNA language model based on multispecies alignment predicts the effects of genome-wide variants
nature.com
A DNA language model based on multispecies alignment predicts the effects of genome-wide variants - Nature Biotechnology
A language model predicts the effects of genetic variants in the human genome.
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 06/01/2025
The highly allo-autopolyploid modern sugarcane genome and very recent allopolyploidization in Saccharum
nature.com
The highly allo-autopolyploid modern sugarcane genome and very recent allopolyploidization in Saccharum - Nature Genetics
A haplotype-resolved genome of hybrid sugarcane cultivar XTT22 and population analyses of Saccharum accessions highlight the genome evolution of allopolyploids and provide opportunities for sugarcane ...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 06/01/2025
RNAGenesis: Foundation Model for Enhanced RNA Sequence Generation and Structural Insights
biorxiv.org
RNAGenesis: Foundation Model for Enhanced RNA Sequence Generation and Structural Insights
RNA plays an essential role in a wide range of biological processes. Gaining a deeper understanding of their functions can significantly advance our knowledge of life's mechanisms and drive the develo...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 05/01/2025
Orthology inference at scale with FastOMA
nature.com
Orthology inference at scale with FastOMA - Nature Methods
FastOMA achieves fast and accurate orthology inference, with linear scalability.
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 05/01/2025
Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana
biorxiv.org
Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana
Background: Centromeres mediate chromosome segregation during cell division. In plants, centromeres are loaded with CENH3-variant nucleosomes, which direct kinetochore formation and spindle microtubul...
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Reposted by Ahmed Elfarargi
PM Delaux @pierremarcdelaux.bsky.social · 01/01/2025
Really pleased to transition from 2024 to 2025 with Tatiana Vernie's work on the evolution of the common symbiosis pathway published @pnas.org 🔽 We finally demonstrate that ☘️ have maintained a genetic pathway to engage with🍄for half a billion years! www.pnas.org/doi/10.1073/...
pnas.org
Conservation of symbiotic signaling since the most recent common ancestor of land plants | PNAS
Plants have colonized lands 450 million years ago. This terrestrialization was facilitated by developmental and functional innovations. Recent evo-...
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Reposted by Ahmed Elfarargi
Fay-Wei Li @fernway.bsky.social · 03/01/2025
Paper #2 - we generated 10 new chr-level genomes for hornworts covering all families and most genera. Also the first look into their U/V sex chromosomes! 3/4 www.nature.com/articles/s41...
nature.com
Pan-phylum genomes of hornworts reveal conserved autosomes but dynamic accessory and sex chromosomes - Nature Plants
This study presents 11 new hornwort (Anthocerotophyta) genomes that clarify the structure and evolution of sex and accessory chromosomes in bryophytes and shed new light on the early evolution of land...
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Reposted by Ahmed Elfarargi
Wolfgang Huber @wkhuber.bsky.social · 03/01/2025
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...
doi.org
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 04/01/2025
Increasing aridity may threaten the maintenance of a plant defence polymorphism
onlinelibrary.wiley.com
Increasing Aridity May Threaten the Maintenance of a Plant Defence Polymorphism
It is unclear how environmental change influences standing genetic variation in wild populations. Here, we characterised environmental conditions that protect versus erode polymorphic chemical defenc...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 04/01/2025
The role of pangenomics in orphan crop improvement
nature.com
The role of pangenomics in orphan crop improvement - Nature Communications
A single reference genome is not enough to harness the full genetic variation of a species. Here, the authors review pangenomics principles, construction and applications for orphan crop improvement, ...
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Ahmed Elfarargi @ahmedelfarargi.bsky.social · 04/01/2025
The genomic secrets of invasive plants
nph.onlinelibrary.wiley.com
The genomic secrets of invasive plants
Genomics has revolutionised the study of invasive species, allowing evolutionary biologists to dissect mechanisms of invasion in unprecedented detail. Botanical research has played an important role ...
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Reposted by Ahmed Elfarargi
Sam Yeaman @samyeaman.bsky.social · 02/01/2025
Gabriele's paper is out in PNAS! He found a large number of genes with repeated sweeps in multiple plant species. Most interestingly: they tend to be peripheral in co-expression networks (low pleiotropy), consistent with mig-sel theory!! @gabnocgenomics.bsky.social www.pnas.org/doi/10.1073/...
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Reposted by Ahmed Elfarargi
Adam Phillippy @aphillippy.bsky.social · 02/01/2025
We may have cut our last Canu release in 2024, but we are starting off 2025 with Verkko2! 🎉 Not only is it 4x faster than Verkko1, this version integrates Hi-C data for both phasing and scaffolding, enabling the automated assembly of acrocentric chromosomes! Preprint: www.biorxiv.org/content/10.1...
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Reposted by Ahmed Elfarargi
Graham Coop @gcbias.bsky.social · 02/01/2025
Congrats to @jeffgroh.bsky.social et al on publication of "Ancient structural variants control sex-specific flowering time morphs in walnuts and hickories" www.science.org/doi/10.1126/...
Science magazine front cover. Picture of a walnut in its opened shell. The text reads "All about timing. Mating type evolution in walnuts and pecans" graphical abstract:
"In Juglans (top left) and Carya, two morphs show complementary temporal separation between male and female flowering (heterodichogamy). Mating types are controlled by two nonhomologous single-locus mechanisms that arose in the common ancestor of each genus, respectively. (Bottom left) Simplified schematic of a putative functional regulatory element at the Juglans locus. (Bottom right) Strong genotypic correlations across the Carya locus indicate a lack of recombination between two colinear haplotypes with similar gene content."
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