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Jaeda Coutinho-Budd

@jcoutinhobudd.bsky.social
570 followers 340 following 13 posts

Assistant Professor @ UVA Neuroscience & BIG Center. Glial biologist and Neuroscientist. 🪰🧠

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Reposted by Jaeda Coutinho-Budd
Rachael Sirianni, PhD @docsirianni.bsky.social · 13/11/2025
Unreal, the impact this is having on scientists. I spent over 700 hrs writing 4 grants submitted Apr-Sept that *might* have been funded next Apr; 2 abt to be 3 apps missed review bc of shutdown. In normal times takes 9-24 mo to get a grant funded. No hope for labs like mine. Literally no hope.
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Dr. Rabbithole @drrabbithole.bsky.social · 13/11/2025
While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.
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bbholmes.bsky.social @bbholmes.bsky.social · 08/09/2025
Our new paper is out! Amyloid plaques switch on microglial GPC4, increasing neuronal tau uptake & toxicity—defining an amyloid→glia→tau pathway & a potential drug target. Pleasure to work with our collaborator @jcoutinhobudd.bsky.social. doi.org/10.1186/s130... #Alzheimers #Glia #Tau #Amyloid
doi.org
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration
To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...
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Ali D. Güler @aguler.bsky.social · 04/09/2025
🚨 We’re hiring! 🧪 @uvabio.bsky.social UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠 Apply by Oct 15, 2025. Start Aug 2026. 👉 apply.interfolio.com/172892 #Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Molecular Neurodegeneration @molneurodegen.bsky.social · 29/08/2025
β-Amyloid induces #microglial expression of GPC4 and #APOE leading to increased neuronal tau pathology and toxicity Brandon B. Holmes, Thaddeus K. Weigel, Jesseca M. Chung...James A. Wells #AlzheimersDisease #drosophila #amyloid #microglia @ucsanfrancisco.bsky.social bit.ly/3HXP98J
molecularneurodegeneration.biomedcentral.com
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration
To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...
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Jaeda Coutinho-Budd @jcoutinhobudd.bsky.social · 29/08/2025
It was fantastic to work with Dr. Holmes and colleagues to integrate work from flies to humans in Alzheimer’s molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration
To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 23/08/2025
The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share
Dear Fly Community,

In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled.

The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC).

Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options.

To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum).

To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu…https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

Our immediate goals are:

1. To maintain core curation activities and keep the FlyBase website online

2. To complete integration with the Alliance of Genome Resources (The Alliance).

Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data.

At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise.

Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028.

We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide.

Sincerely,
The FlyBase Team
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Josh Dubnau @joshdubnau.bsky.social · 22/08/2025
Fly folk: The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource. Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation: wiki.flybase.org/wiki/FlyBase...
wiki.flybase.org
FlyBase:Contribute to FlyBase - FlyBase Wiki
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Jaeda Coutinho-Budd @jcoutinhobudd.bsky.social · 06/08/2025
So excited this is finally out! 🎉 doi.org/10.1002/glia...
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John Tuthill @tuthill.bsky.social · 14/07/2025
i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now www.thetransmitter.org/craft-and-ca...
thetransmitter.org
Fear and loathing on study section: Reviewing grant proposals while the system is burning
As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.
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Anna Gifty @itsafronomics.blacksky.app · 01/07/2025
If your representatives are not REPRESENTING YOU and making life harder for you, you need to fire them. That's it.
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Sharbatanu Chatterjee | শর্বতনু @sharbat.bsky.social · 30/06/2025
WOW, WE'RE DOING TARDIGRADE NEUROSCIENCE? Noice! www.nature.com/articles/d41...
nature.com
Tardigrade-obsessed: meet the researchers trying to turn water bears into neuroscience models
For water-bear enthusiasts, it’s the creature’s legs that make it stand out.
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Jaeda Coutinho-Budd @jcoutinhobudd.bsky.social · 29/06/2025
The man behind me in the grocery line just told the cashier to continue ringing through to his stuff and he was gonna pay for mine. It was literally $200. He said that he’s been going through some stuff lately and he just wants to do something good. 🥹 Reminder: there is still good in this world. ❤️🙏
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AAUP @aaup.org · 28/06/2025
“Campus leaders need to understand that their capitulations and concessions only further empower the greatest threat to higher education since the Red Scare, if not earlier.” (The AAUP contends that this moment is far worse.) Act Now. Never Cave. #DefendHigherEd
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Mathew Kiang @mathewkiang.com · 25/06/2025
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...
ki.se
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
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Kai Ryssdal @kairyssdal.bsky.social · 27/06/2025
Wow. Just wow. University of Virginia President Resigns Under Pressure From Trump Administration www.nytimes.com/2025/06/27/u...
nytimes.com
University of Virginia President Resigns Under Pressure From Trump Administration
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Mark A. Hanson @hansonmark.bsky.social · 03/06/2025
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
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Aakanksha Singhvi @singhvilabglia.bsky.social · 16/06/2025
Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)
wormglia.org
React App
Web site created using create-react-app
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Shane Liddelow @liddelowsa.bsky.social · 15/06/2025
Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_... #Neuroscience #Postdoc #ResearchOpportunity
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Dr. Lucky Tran @luckytran.com · 09/06/2025
"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT. I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up." Thank you to Dr. Jenna Norton and NIH scientists for your courage!
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Jeremy Berg @jeremymberg.bsky.social · 23/04/2025
ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
media.tenor.com
the word alert is in a purple circle
ALT: the word alert is in a purple circle
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James Ross @jamesrossneuro.bsky.social · 17/04/2025
Know anyone looking for a lab specialist/technician job? The Ross lab is hiring! This position will help the lab with our research on anti-tumor immunity in high-grade glioma. Incredible training environment!! 🐭🔬🧪🦠🧠 jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu
Lab Tech/Specialist Varying Levels - Neuroscience in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Lab Tech/Specialist Varying Levels - Neuroscience job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia
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Kevin Hall @kevinh-phd.bsky.social · 16/04/2025
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.
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Carl Zimmer @carlzimmer.com · 16/04/2025
Nature has a story on science tattoos, in which they quoted me about my 2011 book, Science Ink (still in print!) www.nature.com/articles/d41...
nature.com
Science on our sleeves: the research that inspires our tattoos
Inked scientists choose scientific images to mark career accomplishments and illustrate their research passion.
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Joao Pereira @jdpereira.bsky.social · 13/04/2025
I wonder, for those of us on a tenure clock, how will this situation factor in? We’re not playing the same game we set out to play.
media.tenor.com
a man in a suit and tie with nbc written on the bottom right
ALT: a man in a suit and tie with nbc written on the bottom right
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Amelia Eisch 🧪🧠👩‍🔬 🐁 @eisch.bsky.social · 11/04/2025
Bad news for all of us: champion for inclusion & excellence @ NIH/NINDS Dr. Michelle Jones-London is leaving NINDS.💔 She helped launch the career of countless cutting-edge neuroscientists & set the standard for training. Great news of course for where ever she goes next. 🧪🧠@jeremymberg.bsky.social
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Carlos Guardia @charlyguardia.bsky.social · 08/04/2025
NIH PostBac program is open again! And I will be hiring! #JobPostComing www.training.nih.gov/research-tra...
training.nih.gov
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MIT Press @mitpress.bsky.social · 08/04/2025
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
thereader.mitpress.mit.edu
The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
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Jeremy Berg @jeremymberg.bsky.social · 01/04/2025
The horror show continues at NIH I am hearing (reliably) that RIFs have started with entire institute Communication branches being terminated since their jobs not longer exist (reduction in force). But that is not all...
media.tenor.com
a red warning light is lit up in front of a building
ALT: a red warning light is lit up in front of a building
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@LaBonneLaB @labonnelab.bsky.social · 31/03/2025
STILL no New or Competing Renewal awards from NIGMS. Only NIGMS seems to not be making these awards.
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Jaeda Coutinho-Budd @jcoutinhobudd.bsky.social · 28/03/2025
In the midst of everything that’s going on, it’s so nice to be able to appreciate the little things. My lab spent some time away from it all to enjoy time together (and the rest of the amazing scientific community) at the UVA BIG center retreat ❤️
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Jaeda Coutinho-Budd @jcoutinhobudd.bsky.social · 27/03/2025
UVA BIG Center retreat with @tajieharris.bsky.social, @lukensjohnr.bsky.social, Alban Gaultier, and our invited speaker @dimitry-krementsov.bsky.social. Happy to have him out here in beautiful VA!
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Aidan Wright @aidangcw.bsky.social · 24/03/2025
The most common mistake I see with writers is assuming readers know way more than they readers do. Though, it looks a little different for ECRs vs Sr scholars. ECRs assume everyone knows all the background info. Sr scholars assume too much technical knowledge (As is obvious...) 2/2
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Michal Caspi Tal, PhD @immunofever.bsky.social · 07/12/2024
Have you seen this incredible TEDx MIT talk by Linda Griffith? 2 years ago and still wow! How lucky am I that I get to work with her? www.youtube.com/watch?v=_A_T...
youtube.com
Rethinking how we treat endometriosis | Linda Griffith | TEDxMIT
YouTube video by TEDx Talks
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J Brown (they/she) @jfbrown.bsky.social · 21/03/2025
This thread shares that UMich, Yale, U of AZ have set aside funds to support researchers who are getting these disgusting grant announcements from NIH… Who else? This small step should spread…
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Kalev Freeman @uvmtraumalab.bsky.social · 14/03/2025
U of Michigan @umich.edu set aside funds from central to support researchers with unexpected disruption in federal funding for up to 6 months. Are any other institutions doing this? Seems like a good move. #Medsky #NIH #federalfunding #researchfunding 🧪 record.umich.edu/articles/uni...
record.umich.edu
University launches new research support program | The University Record
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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 21/03/2025
The U of Arizona was building a new medical research facility in Phoenix, but it’s now on hold because of uncertain federal funding. It was proposed as a research hub to “find new ways to diagnose, prevent and treat cancers, infectious disease and autoimmune disorders”. Great job DOGE!
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 20/03/2025
The general vibe we are getting across #NIH institutes is deeply bleak — that the agency is nearly, if not already dead. Top people are leaving or have left. Nearly everyone's looking for other jobs. People still care about what NIH was, but are growing resigned to its death. 1/
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Scott Delaney @scott-delaney.bsky.social · 18/03/2025
Substantial updates to the list of cancelled grants👇 - THANK YOU to all who have contributed. Crowdsourcing restores faith in humanity. - It's still a work in progress. You'll see more updates shortly. - There are multiple teams & efforts engaged in tracking & advocacy. More to come soon!
docs.google.com
Rescinded NIH & NSF Grants
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Nicole Rust @nicolecrust.bsky.social · 18/03/2025
Dear trainee friends (et al.), 'Tis true that parts of the sky are falling & this is distracting. However, if you happen to have done A THING (paper, etc.), we want to support you. Don't hold back from letting us know. So we can learn and 👏. We're still here for the science. Sincerely, Everyone
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Denis Wirtz @deniswirtz.bsky.social · 17/03/2025
ICYMI, NIH will be asking soon for each NIH-funded researcher to justify every draw they make (often several times a week) on their grants and every NIH officer and their boss will have to justify their agreeing on these draws. This is the death of US biomedical research by a thousand cuts
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Brooke Harrington @ebharrington.bsky.social · 17/03/2025
YES!!! There is no magical pot of money waiting in Europe for scientists fleeing the US. And it sure as 💩 isn't in Canada, which has been foolishly slashing university funding and all research funding for YEARS. NZ has recently started doing the same. A lot of science will just die on the vine.
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Steve Schwinghamer🇨🇦 @sschwinghamer.bsky.social · 15/03/2025
Hey! Are you an American considering a PhD or a postdoc, and the funding / academic situation just went absolutely bonkers? Canada's federal funding awards just added eligibility for international applicants if at Cdn institutions. www.nserc-crsng.gc.ca/NewsDetail-D...
nserc-crsng.gc.ca
NSERC - Latest News - Launch of the new Harmonized Tri-agency Scholarship and Fellowship programs
As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.
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Jaeda Coutinho-Budd @jcoutinhobudd.bsky.social · 14/03/2025
Couldn’t agree more!
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Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 12/03/2025
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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Mike Greicius @mikegreicius.bsky.social · 13/03/2025
Some encouraging news on the NIH front. The NIA council meeting that was cancelled in January convened virtually in the last day or so and voted on pending grants. This should free up some Alzheimer’s funding.
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Mark Copelovitch @mcopelov.bsky.social · 08/03/2025
👇🎯 The public isn't going to understand this, unless the presidents of R1 universities around the country <loudly> & <collectively> get out into the public square & start explaining this & calling out the existential threat to the entire 🇺🇸 university system. The silence is deafening right now.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 07/03/2025
But this move is a cut. We are hearing approximately 150 SROs will be removed, out of approximately 600. That's in line with Berg's numbers. Removing SROs will slow grant review, and that will reduce grant funding.
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Jeremy Berg @jeremymberg.bsky.social · 05/03/2025
Preliminary injunction in nationwide indirect cost rate case. This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized. www.statnews.com/2025/03/05/n...
statnews.com
Judge issues preliminary injunction blocking Trump cuts to NIH research overhead payments
A federal judge issued a nationwide preliminary injunction blocking the Trump administration from slashing NIH payments for research overhead
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John Skiles Skinner @skiles.blue · 01/03/2025
I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org
18f.org
We're not done yet | 18F
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