Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin-6 (IL-6) inh...

Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.

Find out why David Fajgenbaum is on the TIME100 Health 2025 list.

The spectrum of the rare disorder is expanded with discovery, highlighting the importance of collaboration with patient advocates.

Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeti...

As graduate programs lose spots and labs face shutdowns following Trump administration cuts to science funding, the path to a science career for students and researchers just got a whole lot harder.

Cancer research has had bipartisan support. But Trump administration budget cuts and delays threaten to reverse progress of recent years, experts say.

Senior scientists at the National Institutes of Health fear that research on conditions like obesity, heart disease and cancer will be undermined by President Trump’s policies.

While some NIH study sections will resume, advisory council meetings, which make final funding decisions, seem to still be held up.

Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

The 306th meeting of the National Heart, Lung, and Blood Advisory Council (NHLBAC) convened virtually on Tuesday, February 6, 2024. The Council meeting began with a closed session that started at 10:...

Key Points. Oligocentric Castleman disease (CD) is an intermediate phenotype distinctly characterized from unicentric and idiopathic multicentric CDOligoce

The Trump administration hobbles research and endangers the public health.

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Grants from the National Institutes of Health come with additional money for overhead. A planned $4 billion cut would leave colleges with large budget gaps.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

A patient with longstanding multicentric Castleman’s disease that had progressed after multiple therapies was entering hospice care. Inhibition of tumor necrosis factor will have led to remission f...

Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using germline genome sequencing of 1765 affected children, ...