Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 06/10/2026Super exciting findings and promising transferrable methods to do some impactful meta-science and bioethics work. More evidence to my belief that Roshni’s most interesting paper is always the next one! 🙂↕️ 110
Reposted by Jayati Sharma, PhD, ScMRoshni Patel @roshnipatel.bsky.social · 06/10/2026So excited about this work with @nasalab.bsky.social! Led by Stephanie Gogarten & with help from @daphmarts.bsky.social, we use LLMs as judges to evaluate the use of population descriptors in the entirety of the GWAS Catalog (~4,000 papers published 2007-2025) www.biorxiv.org/content/10.6...biorxiv.orgLarge language model-based bibliometric evaluation of population descriptors in human geneticsAs the use of population descriptors such as race, ethnicity, and ancestry have become increasingly common in modern genetics research, there have been growing calls to critically examine their use. M... 12211
Reposted by Jayati Sharma, PhD, ScMRoshni Patel @roshnipatel.bsky.social · 06/10/2026But, this also illustrates the importance of bottom-up change: decades of work by individual researchers across the field have systematically improved our use of population descriptors in human genetics and genomics. We need to continue to invest in these efforts -- ethics and rigor are intertwined! 143
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 01/10/2026Come pitch us a fun new genetics story @ GeneBites! All flavors of genetics welcome. 001
Reposted by Jayati Sharma, PhD, ScMRoshni Patel @roshnipatel.bsky.social · 14/09/2026These are of course very old questions with tremendous recent progress; we focus mostly on the recent progress and what it offers for the next era of studying human genetics in biobanks. Excited this preprint is out and we'd of course love to hear any thoughts! 12411
Reposted by Jayati Sharma, PhD, ScMGen Wojcik @genandgenes.bsky.social · 19/08/2026Genetics matter, but are not determinative for many many human traits. Even if genetics do influence health (or life in general), they do not influence someone's worth as a human being. Genetics just are. They are not good, they are not bad. They just are. 1154
Reposted by Jayati Sharma, PhD, ScMLiz Neeley @lizneeley.bsky.social · 06/08/2026A scientist who just lost her grant cuts straight to the heart of it: “Requiring that NIH only fund work leading directly to a drug or other biomedical intervention… would rule out much basic research funded by the agency.” It’s pathetic & harmful to limit our understanding of health like this 3329146
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 03/08/2026a lot of science communicators are actually trained to not stay in their area of expertise and instead promoted to be generalists! ask me how i know. this is of course bad, but it is how “people” think scicomm should be. remembering all the covid era science influencers who had 0 epi training. 110
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 14/07/2026ok but hear me out this should be your new pfp. (also im dying at the alt text) 010
Reposted by Jayati Sharma, PhD, ScMChrista Caggiano @christacaggiano.bsky.social · 09/07/2026Working on this project was so fun! ❤️ It's really awesome to work with so many passionate scientists who are all committed to improving our field (despite a climate that might not always be so friendly to that) We'd love any feedback, especially from other trainees and early career researchers! 022
Reposted by Jayati Sharma, PhD, ScMRoshni Patel @roshnipatel.bsky.social · 07/07/2026I think this work really underscores that we are at a turning point in human genetics. There is a growing consensus that doing good research in human genetics requires an expanded skillset (including, e.g., one that can navigate the relationship between genetics, ancestry, and pop descriptors) (1/) 1229
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026pls excuse any and all typos in this thread lol, too excited to proofread! 130
Reposted by Jayati Sharma, PhD, ScMbioRxiv Genetics @biorxiv-genetic.bsky.social · 07/07/2026Recommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchers www.biorxiv.org/content/10.64898/20… 031
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026Tagging the rest of our rockstar team here: @raungar.bsky.social @jpflores.rbind.io @alvinahere.bsky.social @tamigj.bsky.social @dianexue.bsky.social & (untaggable) Krystin Jones, Betzaida Maldonado, and Alyna Khan. 161
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026This work would not have been impossible without the immense efforts of the entire team that helped design, pilot, distribute, interpret, analyze, write & edit. Special thanks to my co-correspondents Roshni @ @christacaggiano.bsky.social for their significant commitments to taking our work this far! 130
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026I remember pitching a commentary-style ELSI piece on this topic to @raungar.bsky.social & @roshnipatel.bsky.social 2+ yrs ago as a late stage grad student w lofty ambitions. Building this all-trainee (at the time) team and has been a real gift for me! So lucky to work with so many like-minded folks. 150
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026Thank you to our survey participants for their very thorough responses to our survey that helped support many of the recommendations that we’ve put forth. Many thanks to @daphmarts.bsky.social, @eimearekenny.bsky.social, & @genandgenes.bsky.social for their support, review, & thoughtful comments. 240
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026To address these, we offer actionable, stakeholder-specific recommendations across the research lifecycle ranging from decision-support tools to "bring-your-own-data" workshops to leadership and trainee mentors. Please read our preprint and let us know your thoughts! www.biorxiv.org/content/10.6...biorxiv.orgRecommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchersDespite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ... 151
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026We found that while exposure to the report fosters ethical awareness, fundamental misconceptions about race and ancestry persist across disciplines. Trainees reported structural bottlenecks, including legacy data constraints and a lack of technical confidence in implementing NASEM guidelines. 130
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026Motivated by our own experience as current trainees and early career researchers (ECRs), we'd seen many ECRs struggle to actually implement the NASEM report recommendations in their work. We wanted to better characterize the reasons for that across the field of computational human genetics. 130
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 07/07/2026In what has been a labor of love & joyful collaboration, we are super excited to share our preprint on recommendations towards the ethical and accurate use of population descriptors generated from a survey by trainees, for trainees. www.biorxiv.org/content/10.6...biorxiv.orgRecommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchersDespite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ... 12610
Reposted by Jayati Sharma, PhD, ScMSatoshi Yoshiji, MD, PhD @satoshiyoshiji.bsky.social · 30/06/2026NIH All of Us has just released a massive multi-omics dataset, including: • 535K WGS (120K+ added; now larger than UKB) • ~10K proteomics + RNAseq + long-read • ML-curated clinical notes • 68K with Fitbit data Kudos to this great initiative and to the participants for advancing science 12213
Reposted by Jayati Sharma, PhD, ScMNonia Pariente @npariente.bsky.social · 29/06/2026"The biases do not disappear; they get encoded into the model and then laundered into outputs that feel objective because they are numerical. Replacing one prestige filter with another that is harder to see or challenge is not progress toward equity in science; it’s the opposite.” 💯🧪 1216
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 16/06/2026this is extremely good. my current writing playlist is dominated by ridgeclub & KatzPascale 🎷🎧 010
Reposted by Jayati Sharma, PhD, ScMJohn Delmenico @thebigjohnnyd.bsky.social · 14/06/2026Mamdani’s New York is having the kind of run that you normally only see in a montage at the end of a Disney Channel movie 115102061068
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 03/06/2026did u know that out of the 12,000 data centers in the world over 4,000 are in the US of A? 😀 011
Reposted by Jayati Sharma, PhD, ScMElise Cutts @elisecutts.bsky.social · 28/05/2026Hey Europe: AC saves lives Hey USA: Gun control saves lives Chart by @hannahritchie.bsky.social (see below) 2153
Reposted by Jayati Sharma, PhD, ScMNeedhi Bhalla 💅🏽 @needhibhalla.bsky.social · 24/05/2026I miss Twitter, mostly because the conversation there for a brief period was so wide-ranging, could be non-hierarchical and forced me to consider view points different than mine. now all of that is splintered between Twitter, Bluesky and threads (😭😭), which feels like a real loss. 3313
Reposted by Jayati Sharma, PhD, ScMRan Blekhman @blekhman.bsky.social · 21/05/2026"This is why LLM AI will not solve cancer or climate change. Those problems require long time horizons, willingness to fail publicly, cooperations across competitors, and subordination of short-term returns to outcomes that may take decades to materialize." www.tomorrowsmess.com/p/the-fox-an...tomorrowsmess.comThe Fox and the HedgehogAmericans are catching on to Silicon Valley's 'One Weird Trick' 0124
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 21/05/2026someday far in the future we will tell children of the mystical Google dot com of decades past: a place where we could ask a question and be directed to at least several dozen factual and valuable* answers written by other real people with actual experience 010
Reposted by Jayati Sharma, PhD, ScMEric Turkheimer @ent3c.bsky.social · 18/05/2026A Substack post on the Nature Human Genetics article. The piece itself is very short, so it is sort of a summary of a summary.ericturkheimer.substack.comPolygenic Scores Are Not Genetic PredispositionsLanguage matters 0124
Reposted by Jayati Sharma, PhD, ScMSandy Ernest Allen @sandyernestallen.bsky.social · 14/05/2026Trans people are being forced to flee red states and for the most part, the press has ignored this story. 17331
Reposted by Jayati Sharma, PhD, ScMashlee, mph @avs.bsky.social · 07/05/2026did you know i am doing a dissertation on workplace leave use among full-time workers in the US who have experienced miscarriage? well now you do! and if you think you may be eligible, you can take a screener survey at go.uic.edu/leavestudy or scan the QR code. #reprosky #healthpolicy #miscarriage 25364
Reposted by Jayati Sharma, PhD, ScMJeremy Berg @jeremymberg.bsky.social · 04/05/2026I just repeated the analysis for grants in fiscal year 2026. I found 98 grants with title changes upon administrative (non-competitive) renewal. Here is the removed word cloud for fiscal year 2026. 4/5 49758
Reposted by Jayati Sharma, PhD, ScMIn These Times @inthesetimes.com · 04/05/2026May Day wasn’t just a day of protest, boycott or celebration. It was a reminder that workers make the world run—and that we’re all on the same team. @hamiltonnolan.bsky.social reports. inthesetimes.com/article/may-... 08824
Reposted by Jayati Sharma, PhD, ScMKevin Bird @stairwaytokevin.bsky.social · 01/05/2026Wow shocker, the eugenics company doesn't care much about actually seeing if their snakeoil workednymag.comAre ‘Designer Babies’ a Scam?Anxious parents are buying $50,000 genetic tests that might not be worth much of anything. 814049
Reposted by Jayati Sharma, PhD, ScMYing Wang @yingwangyw.bsky.social · 23/04/2026🎉New preprint: Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk. We evaluate disease risk along 2 complementary axes: • how genetic liability is represented • the social context in which it is expressed 157
Reposted by Jayati Sharma, PhD, ScMxueyaowu.bsky.social @xueyaowu.bsky.social · 20/04/2026Excited to share our recent paper in #npjBreastCancer! We investigated what drives the AI-generated mammogram risk score (MRS)—a texture feature that predicts breast cancer risk beyond breast density. A thread 👇 @peter-kraft.bsky.social 131
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 25/03/2026gave my first official guest lecture today & have renewed hope in the future. the difference an engaged and curious classroom can make! 🙂↕️ even when the lecture is on molecular epidemiology 🔬 020
Reposted by Jayati Sharma, PhD, ScMJonathan Wosen @jonathanwosen.bsky.social · 19/03/2026@statnews.com conducted a national survey of NIH-funded researchers and found that, a year after Trump's return, many scientists are reeling, with some closing labs entirely. ‘This is like the Titanic,' one respondent told me. For full details, see our special report www.statnews.com/2026/03/19/n...statnews.comNational survey of NIH-funded researchers shows precarious state of U.S. science — ‘This is like the Titanic’A nationwide STAT survey of NIH-funded researchers reveals that, a year after Donald Trump's return to the White House, many scientists are reeling 5132109
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 18/03/2026Finger on the pulse: “Embedding communication and policy fluency into STEM training is not about adding polish. It is about responsibility. Students should graduate knowing not only how to generate knowledge, but how to explain it, contextualize it, and respond when it is misunderstood or misused.”👏 074
Reposted by Jayati Sharma, PhD, ScMPaul Noth @paulnoth.bsky.social · 23/02/2026Mine in this week’s @newyorker.com 2345110
Reposted by Jayati Sharma, PhD, ScMGeneBites @genebites.org · 11/02/2026Happy #InternationalDayofWomenandGirlsinScience! 011
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 31/01/2026another great read — this time on antibiotic resistance — from the talented @amandan-weiss.bsky.social (who’s also our new Social Media Editor)!! genebites.org/2026/01/30/a...genebites.orgAnswer the (KlebPha)Col: a new community resource for Klebsiella phage researchAs bacteria evolve to become more resistant to antibiotics, scientists are revisiting “phage therapy” (using natural viruses that destroy bacteria) as an avenue for treating infections. A new commu… 022
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 31/01/2026or this one on epigenetics and trauma from @pattersonhabitat.bsky.social ‘s ongoing series “Decoding Life”!! genebites.org/2026/01/27/d...genebites.orgDecoding Life: The Echo of TraumaIt’s time to dig a little deeper into some newer genetics concepts. Previously in this series, we have explored the ins and outs of cell division and other genetic processes as a way to dive … 111
Jayati Sharma, PhD, ScM @jayatirsharma.bsky.social · 31/01/2026Despite *gestures broadly*, one bright light for me has been reading and editing so many wonderful pieces from our team at GeneBites on our corner of the internet, like this great one from @jpflores.rbind.io 🐭👇🏼 121