Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...

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Summary: We report the first C. elegans models of alternating hemiplegia of childhood. D801N, E815K, L839P and G947R AHC model animals have recessive development defects and dominant neuromuscular def...

BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.

The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

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Kinesin-1 is an essential anterograde microtubule motor protein. The core kinesin motor is a homodimer of two heavy chains; N-terminal motor domains hydrolyse ATP and walk along microtubules, whilst a...

“Looking back, I’m not sure it was worth the sacrifice,” this scientist writes

Neurons are the largest and most long-lived class of cells, necessitating specialized mechanisms for their survival, growth and maintenance. Axons are the longest extensions of a neuron, reaching len…

The latest Neuromuscular Diseases (NMD) Research Day took place in November 2025, bringing together clinicians, researchers, and partners to strengthen the future of NMD research.

ABSTRACT. Giampietro Schiavo is a Professor of Cellular Neuroscience, Deputy Director for strategy at Queen Square Institute of Neurology, academic lead of the Alzheimer Research UK Drug Discovery Ins...

In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

9 AM Arrival, registration & coffee Session 1: Organelle and synaptic signalling Session Chair: 9:45 AM Introduction 9:50 AM Sally Horton, The Francis Crick Institute, "CDKL5 in synaptic formation,...

Huge congratulations to the UCL Queen Square Institute of Neurology staff who have been awarded a promotion in this year's promotions round.

Nature Communications - Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of...