A great story from the Twiss Lab! Who knew that a little finding we had >10 yrs ago would turn lead to a beautiful example of intrinsic control during axon regeneration.
An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis www.science.org/doi/10.1126/...
science.org
An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis
Injured axons synthesize the RNA Binding Protein KHSRP that promotes mRNA decay and slows nerve regeneration. Axotomy-induced increase in axoplasmic Ca2+ activates axonal Khsrp translation, and while ...