Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...

The Ohio Department of Medicaid department in 2022 gave powerful prescription drug middlemen the boot and created a new system. The result: Fees paid to pharmacies were boosted more than 1,200% while ...

Gavin Nielsen, who was 2 years old when he was diagnosed with a rare brain cancer, met Dr. Nicholas Vitanza who is part of a growing group of researchers exploring CAR-T therapy. The treatment program...

Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.

Nature Metabolism, Published online: 17 March 2025; doi:10.1038/s42255-025-01237-6This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological,…

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

Nature Biotechnology - Pricey sickle cell gene therapies primed for change

Mitochondria rapidly take up calcium (Ca2+) from the cytoplasm and neighbouring organelles upon an increase in local and global calcium levels, thereby stimulating metabolism and regulating processes ...

Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.

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Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which regenerates cytosolic NAD+ via ...

Here the authors describe the different ways that cancer cells evade the immune system and how these mechanisms impact immunoediting and tumour clonality. They suggest that in tumours that become high...

Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

Hallucinations, a bane of popular A.I. programs, turn out to be a boon for venturesome scientists eager to push back the frontiers of human knowledge.