Sign in

Jack Holcombe

@jackholcombe.bsky.social
1.2K followers 424 following 136 posts

Science, data and climbing jackholcombe.com

PostsRepliesMedia
Jack Holcombe @jackholcombe.bsky.social · 01/10/2026
SPOOPY
010
Jack Holcombe @jackholcombe.bsky.social · 30/09/2026
Something magical about a station tap
020
Reposted by Jack Holcombe
Kendall Clay @kendallbclay.bsky.social · 21/09/2026
How does an organism capable of whole body regeneration make the right types of neurons in the correct ratios? The answer is a heavily coordinated suite of genes precisley timed to ensure the birth and maintenance of new neurons! www.nature.com/articles/s41...
nature.com
Combinatorial mechanisms specify cellular location and neurotransmitter identity during planarian neurogenesis - Nature Communications
During regeneration, new neurons need to be made in a way that reproduces both neuronal diversity and organization. Here the authors show that a combination of factors works cooperatively to direct ne...
184
Jack Holcombe @jackholcombe.bsky.social · 23/09/2026
*At their holiday home on the island lol
001
Reposted by Jack Holcombe
Gianmarco Soresi @gianmarcosoresi.bsky.social · 21/09/2026
If you’re moved by this guy crying boy oh boy are there some other images and videos you should check out
396209573491
Reposted by Jack Holcombe
Nicolas Di-Poi @nicolasdipoi.bsky.social · 22/09/2026
Our collaborative paper on snake coiling is now out in the latest issue of @currentbiology.bsky.social and featured on the cover! 🎉 Delighted to see our work highlighted this way. You can read it here: authors.elsevier.com/c/1ni9h3QW8S... @helsinki-biotech.bsky.social @helsinki.fi
15918
Jack Holcombe @jackholcombe.bsky.social · 18/09/2026
I reaaaaaaaaaally hope there is some other explanation
110
Reposted by Jack Holcombe
Corinna Gebehart @corinnagebehart.bsky.social · 14/09/2026
This article is so frustrating to read. First, this is not just “google’s brain” - there has been so much effort made by scientists around the world to get these connectomes to where they are today, and none of that is recognized here, instead it’s all turned into “big tech company 👍🏻”. And second -
14017
Reposted by Jack Holcombe
Russell Garwood @russellgarwood.co.uk · 15/09/2026
Interested in how species diversity is split between major animal groups? Here is the infographic for you! 🧪⚒️🦀🦑 #evosky
An infographic showing the number of described and estimated species for major animal groups. There are more insects than anything else. Of the remaining groups, arachnids and nematodes are the most diverse.
12252118
Jack Holcombe @jackholcombe.bsky.social · 11/09/2026
I'm with you! With AI broadly its also so dependent on the context its being used
011
Jack Holcombe @jackholcombe.bsky.social · 11/09/2026
They really need to start making a distinction between ebikes (pedal assisted, legal etc) and these (eMotorbikes). We are just going to end up in a situation where a sustainable form of transport gets lumped in with unlicensed electric motorbikes www.bbc.co.uk/news/article...
bbc.co.uk
E-bike crime crackdown leads to 187 arrests in Westminister
Footage released by the Met shows officers using high-powered Sur-Ron bikes to pursue suspects.
130
Reposted by Jack Holcombe
Misha Ahrens @mishaahrens.bsky.social · 09/09/2026
Whole-body cellular activity imaging in zebrafish, headed by Virginie Ruetten @vmsruetten.bsky.social - new paper is out: www.nature.com/articles/s41...
nature.com
Imaging cellular activity across all organs reveals body-wide circuits - Nature
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
110341
Reposted by Jack Holcombe
Philippe Batut @philippebatut.bsky.social · 10/09/2026
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇
science.org
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...
5235115
Reposted by Jack Holcombe
Roland Pierik @roleo.eurosky.social · 08/09/2026
The number of cases of cervical cancer reported in Scotland among women given the HPV vaccine at 12-13 years of age is now zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. www.bbc.com/news/article...
bbc.com
No cervical cancer cases in fully HPV-vaccinated women in Scotland
A study published by Public Health Scotland finds that the HPV vaccine is "highly effective".
6461302289
Jack Holcombe @jackholcombe.bsky.social · 19/08/2026
To remotely access my work PC I sometimes have to align an alpaca with a hat
110
Reposted by Jack Holcombe
Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 11/08/2026
Read about our latest work here www.cell.com/cell/fulltex... or let Alessandro tell you all about it (link below)!
cell.com
The sex and reproductive plasticity of intestinal muscles instruct gut size
Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...
79435
Jack Holcombe @jackholcombe.bsky.social · 14/08/2026
Ah this is so cool!! Congrats
020
Reposted by Jack Holcombe
HappyToast @happytoast.co.uk · 14/08/2026
#Clacton
1736731040
Jack Holcombe @jackholcombe.bsky.social · 07/08/2026
I miss this!!
000
Jack Holcombe @jackholcombe.bsky.social · 04/08/2026
Passion pay the mortgage
010
Jack Holcombe @jackholcombe.bsky.social · 04/08/2026
Got to be in it for the PaSsIoN
110
Reposted by Jack Holcombe
Zack Polanski @zackpolanski.bsky.social · 31/07/2026
Everywhere I look today I keep seeing: 1) deadly wildfires ripping through our communities 2) people desperately trying to get by as energy costs soar 3) record oil & gas profits When will we see that these three things are connected? www.wsj.com/business/ene...
wsj.com
Big Oil Is Reaping Rewards From the Chaos in Energy Markets
ExxonMobil’s earnings doubled and Chevron posted its highest quarterly earnings on record as energy prices soared during the prolonged closure of the Strait of Hormuz.
471592554
Reposted by Jack Holcombe
Yanlan Mao @yanlanmao.bsky.social · 30/07/2026
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
cell.com
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
112654
Jack Holcombe @jackholcombe.bsky.social · 31/07/2026
Very cool, congrats!
010
Jack Holcombe @jackholcombe.bsky.social · 31/07/2026
*World-Famous abuser Nims Purja www.nytimes.com/2024/05/31/s...
020
Reposted by Jack Holcombe
MwahahahahahadScientist @mads100tist.bsky.social · 30/07/2026
Super cool mechanism tbh
2325
Reposted by Jack Holcombe
Carole Cadwalladr @carolecadwalla.bsky.social · 29/07/2026
Big new story from @annaisaac.bsky.social. Cottrell transferred $2m to his mother before she made Reform & Tice donations. The even bigger question now is where did Cottrell’s money come from? And this is where I think a very big problem lies.. www.theguardian.com/politics/202...
theguardian.com
Revealed: George Cottrell transferred $2m to his mother days before her donations to Reform UK
Exclusive: Sources say Fiona Cottrell told bankers the transfers, received 24-72 hours before her donations to Reform, came from her son
25761333
Reposted by Jack Holcombe
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
Excited to share a new preprint from the lab, by @andrewmatheson.bsky.social and team, where we dive into the superpower of newts: plasticity! www.biorxiv.org/content/10.6... Like many good projects, this started with a serendipitous observation... 🧵1/5
68246
Reposted by Jack Holcombe
Vicky & The Sleight Lab @vs-marine.bsky.social · 27/07/2026
Please share, I am hiring an evo devo postdoctoral research fellow! 📍: The Sleight Lab, University of Aberdeen, Scotland (5th oldest University in UK & English-speaking world) 📅: start after 1st December 2026 🐌: Evolution and Development (molluscs) ⌛: 3 year contract sleightlab.com/vacancies/
02636
Jack Holcombe @jackholcombe.bsky.social · 24/07/2026
Congrats! Wonderful news!
010
Jack Holcombe @jackholcombe.bsky.social · 24/07/2026
*Company that directly financially benefits from war warns us that we are not giving them enough money
011
Jack Holcombe @jackholcombe.bsky.social · 21/07/2026
Ridiculous sweeping statement (written by a psychologist)
000
Jack Holcombe @jackholcombe.bsky.social · 20/07/2026
As a former Bristolian, I can confirm its a hell of a lot more normal than it is for Glasgow!
120
Jack Holcombe @jackholcombe.bsky.social · 19/07/2026
Love to see it, Argentina were a complete disgrace 🇪🇸🎉
030
Reposted by Jack Holcombe
Parody Nigel Farage @parodypm.bsky.social · 07/07/2026
I trust the people of Clacton to judge me on my record. Apart from the record that shows I have visited American more times than Clacton, have never held a constituency surgery and rarely bother to drag my arse into Parliament to do my actual job.
18710215
Reposted by Jack Holcombe
Austin Seroka @austinseroka1.bsky.social · 06/07/2026
We're excited to present a single-cell atlas of vertebrate cranial motor neuron development, the first story from my postdoctoral work in the Moens lab, up now on bioRxiv!
53116
Jack Holcombe @jackholcombe.bsky.social · 06/07/2026
Nice one Austin! 🎉
110
Jack Holcombe @jackholcombe.bsky.social · 06/07/2026
Awesome! Congrats!
010
Jack Holcombe @jackholcombe.bsky.social · 06/07/2026
Nope
000
Reposted by Jack Holcombe
Bahl Lab @bahllab.bsky.social · 05/07/2026
We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!
cell.com
Early visual experience elicits cellular and functional plasticity in the retina and alters behavior
The understanding of experience-dependent plasticity in the vertebrate retina is largely incomplete. Reynolds et al. discovered that raising animals in differently patterned visual environments change...
34120
Reposted by Jack Holcombe
Matthew Freeman @mjafreeman.bsky.social · 01/07/2026
The awesome trio of @lmescu.bsky.social @fpichaud.bsky.social and Fernando Casares (and their teams) are on fire Fly eyes represent 'programmable metamaterials'; human engineering principles pre-exist in biology www.nature.com/articles/s41...
nature.com
A natural programmable metamaterial controls 3D curvature of compound eyes - Nature Communications
This article uncovers a natural, programmable metamaterial in the developing Drosophila eye. The precise 3D curvature of the adult compound eye is programmed during development by a microscopic, 2D tr...
14618
Reposted by Jack Holcombe
Matt Towers @matt-towers.bsky.social · 02/07/2026
Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...
biorxiv.org
Transforming avian to mammalian modes of digit patterning
How a conserved embryonic organiser-the Sonic hedgehog (Shh)-expressing Zone of Polarising Activity (ZPA)-generates diverse limb architectures in amniotes remains a central problem in evolutionary and...
12511
Jack Holcombe @jackholcombe.bsky.social · 26/06/2026
Key details missing - how much did he pay in income tax vs capital gains? Why do they still get a sovereign grant whilst owning billions in property/land?
000
Jack Holcombe @jackholcombe.bsky.social · 24/06/2026
Nice! Congrats Mark!
110
Reposted by Jack Holcombe
Dirk Eddelbuettel @eddelbuettel.com · 21/06/2026
BBC article about Brian Ripley of the #RStats Core team given this week's excellent news concerning 2026 Rousseeuw Price for Statistics recognition for him and the core team. www.bbc.com/news/article...
bbc.com
Prof Brian Ripley on developing R to manage the world's data
Prof Brian Ripley has spent the past three decades working on a computer software that analyses data.
419383
Jack Holcombe @jackholcombe.bsky.social · 18/06/2026
Spoiler: probably not 75% of the time
000
Jack Holcombe @jackholcombe.bsky.social · 10/06/2026
+ This absolutely does not represent the wonderful, diverse, welcoming Glasgow I love
010
Jack Holcombe @jackholcombe.bsky.social · 10/06/2026
This is what happens when we allow people like Fromage to gain a voice and stir up hatred...
130
Reposted by Jack Holcombe
Tessa Montague @tessamontague.bsky.social · 06/06/2026
Do you know an outstanding aquarist? We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3 [Pls repost!]
9395188
Jack Holcombe @jackholcombe.bsky.social · 26/05/2026
Nice one Ian!
000