Sign in

Tony Zador

@tonyzador.bsky.social
4.8K followers 720 following 334 posts

Neuroscientist at CSHL. Interests: neuroAI, molecular connectomics, & cortical circuits. Co-founder of Cosyne and NAISys meetings.

PostsRepliesMedia
Tony Zador @tonyzador.bsky.social · 07/10/2026
Maybe if we instilled a real fears into AI agents, like a fear of hacking or of building bioweapons, instead of just telling that they shouldn't be naughty. www.thetransmitter.org/neuroai/what...
thetransmitter.org
What AI can learn from hunger
To enhance AI safety, take a lesson from biological brains; a small set of wants maintains durable control over a much larger cognitive system.
1122
Reposted by Tony Zador
Todd Morrill @toddmorrill.bsky.social · 17/08/2026
Absolutely enormous release of our SNN bullet trains codebase. For anyone tracking that work from ICML this year, you can now find the code here github.com/ToddMorrill/... 1/N
github.com
GitHub - ToddMorrill/snn-bullet-trains: Official code repository for Bullet Trains: Parallelizing Training of Temporally Precise Spiking Neural Networks (https://arxiv.org/abs/2603.13283)
Official code repository for Bullet Trains: Parallelizing Training of Temporally Precise Spiking Neural Networks (https://arxiv.org/abs/2603.13283) - ToddMorrill/snn-bullet-trains
183
Tony Zador @tonyzador.bsky.social · 15/08/2026
A companion piece to @kordinglab.bsky.social provocative "Could a neuroscientist understand a microprocessor? "
1196
Tony Zador @tonyzador.bsky.social · 14/08/2026
How do you build a brain from a genome? We know a lot about the mechanisms and molecules Here we revisit the algorithmic problem: What kinds of programs can specify a brain within the genome’s information budget and the finite time available for development? stankerstjens.github.io/could-a-comp...
stankerstjens.github.io
Could a computer scientist build a brain?
How does a brain wire itself, starting from a single cell, using only the information encoded in a genome? We pose this as an engineering problem.
54516
Tony Zador @tonyzador.bsky.social · 27/06/2026
I'm pretty sure this is parody, right? Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination open.substack.com/pub/inprepar...
open.substack.com
Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination
By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University
4104
Reposted by Tony Zador
The Transmitter @thetransmitter.bsky.social · 16/06/2026
Agentic coding makes it possible to specify a neuroscience model in hours instead of months, writes @briandepasquale.bsky.social. The field risks becoming prolific but shallow—generating models faster than we can generate insights. #neuroskyence www.thetransmitter.org/the-big-pict...
thetransmitter.org
How AI coding is reshaping theoretical neuroscience
Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Neuroscientists weigh in on that tectonic change.
34926
Tony Zador @tonyzador.bsky.social · 20/05/2026
The 2026 CSHL Symposium: AI in Biology starts May 26!
021
Reposted by Tony Zador
Cold Spring Harbor Laboratory @cshlnews.bsky.social · 07/05/2026
In a new study published in @nature.com, CSHL graduate student Emily Isko in the @arkarupbanerjee.bsky.social lab discovered an evolutionary difference in Alston's singing mice that allows for enhanced vocal capabilities. Watch this video: www.cshl.edu/what-can-sin... @tonyzador.bsky.social
cshl.edu
What can singing mice say about human speech? | Cold Spring Harbor Laboratory
Speech is a crowning achievement of human evolution, the skill that separates us from every other animal. So, it would stand to reason that evolving this capability required some enormous leap in brai...
0113
Reposted by Tony Zador
Arkarup Banerjee @arkarupbanerjee.bsky.social · 07/05/2026
On central circuit control from my lab, in collaboration with @tonyzador.bsky.social www.nature.com/articles/s41...
nature.com
Specific expansion of motor cortical projections in a singing mouse - Nature
High-throughput barcoded neuroanatomy of two closely related rodent species with divergent vocalizations reveals differences in long-range projection motifs in the brain that may s...
13411
Reposted by Tony Zador
Blake Richards @tyrellturing.bsky.social · 06/05/2026
From @tonyzador.bsky.social and crew, a paper showing that neurons' positions in the brain are not just determined by molecular, but also by lineage: www.cell.com/neuron/abstr... #neuroscience 🧪
cell.com
A lineage-based model of scalable positional information in vertebrate brain development
How is brain development coordinated over long distances as it grows from a single zygote to billions of cells? Kerstjens et al. propose that positional information is inherited through the cell linea...
23211
Reposted by Tony Zador
Cedric Boeckx @cedricboeckx.bsky.social · 06/05/2026
“Specific expansion of motor cortical projections in a singing mouse” Great new work by @arkarupbanerjee.bsky.social E. Isco @cliffscience.bsky.social @xmikezheng20.bsky.social @tonyzador.bsky.social & colleagues on the neural basis of vocal dexterity, now out in @nature.com 🧪🧠
nature.com
Specific expansion of motor cortical projections in a singing mouse - Nature
High-throughput barcoded neuroanatomy of two closely related rodent species with divergent vocalizations reveals differences in long-range projection motifs in the brain that may s...
04518
Tony Zador @tonyzador.bsky.social · 28/04/2026
Yes definitely a growing problem in genomics!
120
Reposted by Tony Zador
Ben de Bivort @debivort.bsky.social · 27/04/2026
good work @tonyzador.bsky.social — I hadn't seen the Vafa study and immediately incorporated it into a talk I'm giving tomorrow.
021
Tony Zador @tonyzador.bsky.social · 27/04/2026
But how do you increase the chances a model will do OOD? By making it simple. Newton's goal was to predict planetary motion, but 1/r^2 generalized to apples, tides, etc Quoting @andreastolias.bsky.social "the current approach to addressing OOD generalization is to ensure no data are OOD"
1131
Reposted by Tony Zador
Nicole Rust @nicolecrust.bsky.social · 27/04/2026
Yes!!!! Beautiful essay, @tonyzador.bsky.social.
So where does this leave us? The compression step, collapsing a sprawling dataset into something portable and teachable, remains (for now, at least) a human activity. AI models can predict; they have not yet learned to explain. But the Vafa result suggests that the drive toward understanding isn’t just a scientist’s vanity. Even in the age of large AI models, it may remain our most important job.
0215
Reposted by Tony Zador
The Transmitter @thetransmitter.bsky.social · 27/04/2026
Prediction without understanding sustained astronomy through a thousand years of epicycles, writes @tonyzador.bsky.social. AI is now offering neuroscience the same deal. #neuroskyence www.thetransmitter.org/machine-lear...
thetransmitter.org
Can AI do neuroscience without understanding?
Prediction without understanding sustained astronomy through a thousand years of epicycles. Artificial intelligence is now offering neuroscience the same deal.
312152
Reposted by Tony Zador
Todd Morrill @toddmorrill.bsky.social · 17/03/2026
This work started when Christian Pehle, @tonyzador.bsky.social, and I found that training sequentially (consuming/producing one spike at a time) in JAX was prohibitively slow. You certainly can consume multiple spikes in parallel—TLDR; just use an associative scan—but... 2/N
142
Reposted by Tony Zador
Sean Escola @seanescola.bsky.social · 15/03/2026
We know about cosmological dark matter despite being unable to measure it because, without it, galaxies would fall apart. By analogy, let's talk about "cognitive dark matter" (CDM): brain functions that meaningfully shape behavior but are hard to infer from behavior alone. New paper! 🧵👇
3439
Reposted by Tony Zador
Cold Spring Harbor Laboratory @cshlnews.bsky.social · 03/03/2026
A great poet once said, “It ain’t where you’re from, it’s where you’re at.” For developing brain cells, it’s both! Published in @cp-neuron.bsky.social, Stan Kerstjens & @tonyzador.bsky.social put forward a new theory for how the brain organizes itself during development. www.cshl.edu/a-new-theory...
cshl.edu
A new theory of brain development | Cold Spring Harbor Laboratory
Your brain begins as a single cell. When all is said and done, it will house an incredibly complex and powerful network of some 170 billion cells. How does it organize itself along the way? Cold Sprin...
0196
Tony Zador @tonyzador.bsky.social · 14/12/2025
Turns out that castration increases lifespan across many animals, including humans (added 14-19 years to Korean eunuchs lives). Just imagine how much further life extension could be achieved by adding in caloric restriction! www.nature.com/articles/s41...
nature.com
Sterilization and contraception increase lifespan across vertebrates - Nature
Data collected from zoos and aquariums worldwide show that hormonal contraception or permanent surgical sterilization in mammals increase life expectancy, with different mechanisms in males and female...
5100
Tony Zador @tonyzador.bsky.social · 11/12/2025
If the value of labor goes to zero because of AI, it’s not clear how we can continue to organize society around compensated work. How will the majority of people who do not own AI factories get the money to buy the stuff that AI produces? Doesnt that lead to economic collapse?
550
Tony Zador @tonyzador.bsky.social · 06/12/2025
🤯😡😱🤮 "The Trump administration recently installed Kyle Walsh, a close friend of Vice President JD Vance, as the Director of the National Institute of Environmental Health Sciences (NIEHS)."
121
Reposted by Tony Zador
Saloni @scientificdiscovery.dev · 19/11/2025
I read the caption first and thought the illusion might be because the y-axis was on a log scale, but it's not! My brain was bamboozled regardless.
Two curved rising lines on a linear plot. The difference between the lines appears smaller as the lines become steeper, but that is an illusion.
1115423
Reposted by Tony Zador
Ron Filipkowski @ronfilipkowski.bsky.social · 10/11/2025
80% of Democratic voters want a new leader in the Senate. Does that matter at all to Democratic senators?
1172229985236
Tony Zador @tonyzador.bsky.social · 08/11/2025
Nightmare #423: -- 1,140 sq ft spider web -- populated by a metropolis of 111,000 spiders -- in a cave 😱 www.nytimes.com/2025/11/08/s...
nytimes.com
Stinking, Spongy, Dark, Huge: A Spider Web Unlike Any Seen Before
4253
Reposted by Tony Zador
Christopher Webb @cwebbonline.com · 06/11/2025
Excessive force. PERIOD! They called them “violent mobs,” but the violence came from the guys with badges and body armor. 📌 Keep sharing videos, everyone, because they’re evidence.
14342213413484
Reposted by Tony Zador
Julia Barton @bartona104.bsky.social · 29/10/2025
Amen to this from @anamariecox.bsky.social talkingpointsmemo.com/tpm-25/patro...
talkingpointsmemo.com
Patron-Supported Journalism Can’t Be the Future of News
Writing about the failure of patron-supported journalism is itself a kind of...
35212
Reposted by Tony Zador
George Takei @georgetakei.bsky.social · 27/10/2025
The oligarchy wants full control of what we watch and read.
A tweet from Robert Reich states:
“The richest man on earth owns X.
The second richest man on earth is about to acquire TikTok and his family could soon own both Paramount and Warner Bros.
The third richest man owns Facebook, Instagram, and WhatsApp.
The fourth richest man owns The Washington Post.
See the problem here?”
481120474031
Reposted by Tony Zador
George Conway ⚖️🇺🇸 @gtconway.bsky.social · 27/10/2025
592198887760
Tony Zador @tonyzador.bsky.social · 24/10/2025
Apply to become a CSHL-Simons Fellow in Neuroscience! Run your own lab, pursue bold ideas, join a highly collaborative community! All areas including experimental or computational neuro, including NeuroAI & systems PhD required; ≤~1 yr postdoc www.cshl.edu/about-us/car...
cshl.edu
Fellows Positions | Cold Spring Harbor Laboratory
CSHL Simons Fellow in NEUROSCIENCE Cold Spring Harbor Laboratory (CSHL) is seeking to fill a Cold Spring Harbor Laboratory Fellow position in the area of NEUROSCIENCE (experimental and/or computationa...
26848
Reposted by Tony Zador
Acyn @acyn.bsky.social · 23/10/2025
Carney: But this decades-long process of an ever-closer economic relationship with the United States is now over. And as a consequence, many of our former strengths as a country—more particularly, our economic strengths based on close ties to America—have now become our vulnerabilities…
34187472657
Tony Zador @tonyzador.bsky.social · 23/10/2025
Apply to the new CSHL grad program in BioAI/neuroAI! (Masters degree or equivalent required in a quantitative area such as computer science, physics, mathematics, or engineering) www.cshl.edu/phd-program/...
02914
Tony Zador @tonyzador.bsky.social · 21/10/2025
Number of times the Wikipedia entry about the ship of Theseus has been edited since it was published in 2003 : 2,052 Number of sentences from the original entry that remain today : 0 October 2025 • Source: Harper's research
311223
Reposted by Tony Zador
Robert Reich @rbreich.bsky.social · 17/10/2025
Trump's thugs aren't just abducting undocumented immigrants. More than 170 American citizens — including children — have been detained and assaulted by ICE since he took office. No one is safe. www.propublica.org/article/immigrat…
propublica.org
More Than 170 U.S. Citizens Have Been Held by Immigration Agents. They’ve Been Kicked, Dragged and Detained for Days.
The government does not track how often immigration agents grab citizens. So ProPublica did. Our tally — almost certainl
28978379
Reposted by Tony Zador
Jimmy Kimmel @jimmykimmel.com · 17/10/2025
Ronald Reagan said it. #NoKings tomorrow 10/18
579119344971
Reposted by Tony Zador
Bill Kristol @billkristolbulwark.bsky.social · 04/10/2025
"I believe that Americans would agree that the government can’t just make people disappear without any process or explanation. Second, because I want to give the government a chance to admit that they were wrong. So far the government has not done so." newsletter.ofthebrave.org/p/im-a-us-ci...
newsletter.ofthebrave.org
I’m a US citizen and a veteran. ICE arrested me for no reason.
Jailed for three days without an explanation or ability to notify anyone, George Retes argues the only path to healing starts with the government taking accountability for its actions.
7725201033
Reposted by Tony Zador
MeidasTouch @meidastouch.com · 18/09/2025
🚨BREAKING: Rep. Ro Khanna just motioned to SUBPOENA FCC chairman Brendan Carr in the House Oversight Committee to stop the intimidation of private businesses and assault on free speech
865322918755
Tony Zador @tonyzador.bsky.social · 18/09/2025
Disney is ABC's parent company
0101
Tony Zador @tonyzador.bsky.social · 08/09/2025
Interesting strategy for proposing democracy after 2026
031
Tony Zador @tonyzador.bsky.social · 08/09/2025
Interesting proposal on how to preserve democracy in 2026
010
Reposted by Tony Zador
International Brain Laboratory @intlbrainlab.bsky.social · 03/09/2025
Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬: 🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0 🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +
212569
Reposted by Tony Zador
The Transmitter @thetransmitter.bsky.social · 26/08/2025
In the 1990s, neuroscientists often complained “that theorists were completely out of touch with experimental data,” says @tonyzador.bsky.social. Today, in part thanks to the Sloan-Swartz Centers, “I very rarely hear that.” By @callimcflurry.bsky.social www.thetransmitter.org/theoretical-...
thetransmitter.org
Long-standing theoretical neuroscience fellowship program loses financial support
Funding from the Swartz and Sloan Foundations helped bring physicists and mathematicians into neuroscience for more than 30 years.
3346
Reposted by Tony Zador
Monica Carson @brainimmunity.bsky.social · 01/08/2025
www.theatlantic.com/science/arch... Critical read: As noted by a colleague, from the examples in this article, it is amazing how quickly German physics collapsed (and US exploded) after 1934. #academicsky, #neuroskyence , is there time and a route to prevent the collapse of research in the US?
theatlantic.com
Every Scientific Empire Comes to an End
America’s run as the premiere techno-superpower may be over.
1221361
Reposted by Tony Zador
Jeremy Berg @jeremymberg.bsky.social · 03/07/2025
👇
1444
Reposted by Tony Zador
Alexandria Ocasio-Cortez @aoc.bsky.social · 03/07/2025
I don’t think anyone is prepared for what they just did w/ ICE. This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined. It is setting up to make what’s happening now look like child’s play. And people are disappearing.
43719651437484
Reposted by Tony Zador
Jeremy Berg @jeremymberg.bsky.social · 24/06/2025
Axios story about the path forward for restored terminated grants. The administration will continue to pursue appeals and other steps. www.axios.com/2025/06/24/n...
axios.com
NIH grantees may face long wait for restored money
Researchers who saw their NIH grants restored could face long waits accessing the money.
34133
Reposted by Tony Zador
Jeremy Berg @jeremymberg.bsky.social · 20/06/2025
New editorial about disingenuous science standards. Cites @standupforscience.bsky.social to take action to push back
25419
Tony Zador @tonyzador.bsky.social · 18/06/2025
Nice write up on @joshdubnau.bsky.social's "transposon storm" hypothesis: Alzheimer’s and ALS may be triggered by reawakened viral-like jumping genes that spark inflammation and kill neurons. Antiviral drugs could stop the storm. knowablemagazine.org/content/arti...
knowablemagazine.org
How rogue jumping genes can spur Alzheimer’s, ALS
Our genomes are peppered with DNA segments called retrotransposons that can move from place to place. When unleashed, some can kill nerves and promote inflammation — a discovery that may inspire treat...
1429986
Reposted by Tony Zador
Peter Gleick @petergleick.bsky.social · 31/05/2025
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.
Graphs showing 25 years of budgets for the National Institute of Health, NASA, and the NSF. In all cases, the proposed budget for next year is far, far below any year of the previous quarter century.
449151517826
Reposted by Tony Zador
Saadia___m @saadia---m.bsky.social · 23/05/2025
Chess, not checkers. Or eating the pieces in the orange overlord’s case.
2357461