Synchronized and desynchronized patterns of spontaneous activity during brain development prepare cortical circuits such as the visual cortex for processing external sensory information. Yet the neuro...

The populations of CRHR2-expressing neurons in the lateral septum of mice involved in threat-related behaviour in response to environmental challenges are defined.

Neural activity is a fundamental driver of early circuit assembly, yet how it shapes the distribution of inhibitory neurons across sensory networks remains poorly understood. Establishing an appropria...

Short-term alcohol exposure modulates activity in reward-related regions such as the ventral tegmental area (VTA) and executive cortical regions such as the prefrontal cortex (PFC), potentially contri...

The genetically encoded voltage indicators JEDI3sub and JEDI3hyp enhance monitoring of subthreshold neuronal activity in the awake mouse brain using a variety of two-photon microscopy techniques.

PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...

In this study, the authors develop CaMPARI-seq to link neural activity with molecular profiles in larval zebrafish. They identify inhibitory pretectal neurons required for optomotor response, revealin...

Abstract. Investigating the developmental characteristics of fetal brain functional activity and connectivity is crucial for understanding normal developme

The ERC plans to launch the grant competitions under its 2027 Work Programme between July 2026 and June 2027, with the calls for proposals introducing several changes to the eligibility rules for appl...

Short-term alcohol exposure modulates activity in reward-related regions such as the ventral tegmental area (VTA) and in executive cortical regions such as the prefrontal cortex (PFC), potentially con...

In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...

Blumberg et al. present video evidence of twitching during adult sleep in a diverse sample of animals. Adult twitching appears to selectively involve appendages used for active sensing, mirroring thei...

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to th...

I will soon hit the academic job market, and hopefully not be crushed by it (the academic job market is tough!) Fortunately, there are now fantastic resources from researchers and institutions that…

Jupyter notebook templates for processing and analyzing neuroscience data. - dav1dcg/neuro-notebook-templates

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to th...

Kornfeld-Sylla et al reveal how alpha brainwaves are altered in children and adults with Fragile X Syndrome (FXS) and find parallel changes in alpha-like rhythms in juvenile and adult FXS model mice, ...

Precise control of individual neuron firing is key for neuroscience. Here, the authors show a novel opsin-free photostimulation method that activates single neurons in vivo by femtosecond laser scanni...

While traditional antipsychotic drugs provide symptomatic relief for positive symptoms in patients with schizophrenia, many patients are refractory to traditional antipsychotics. Furthermore, these me...

Dr. Yulong Li received his undergraduate education in biophysics and physiology at Peking University, and subsequently completed his Ph.D. training un…

Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...

In this blog, you can find tutorials for analyzing electrophysiological properties using Python and the software Clampfit (see full list here). In the end, you generally get tabular data with numer…

Striatal cholinergic interneurons promote flexible behavior by unknown mechanisms. Here, authors show that spatially heterogeneous acetylcholine signals promote adaptive lose-shift choices in response...

Papadopoulos et al. report an inverted-U relationship between tone discriminability and arousal in mouse auditory cortex. A spiking network model with clustered connectivity explains the effects via m...

Tong and colleagues reveal a cross-species conserved mechanism where locus coeruleus-norepinephrine mediated arousal fluctuations drive an inverted U-shaped pattern of global functional connectivity, ...

Code from the neuroscience blog Spikes and Bursts. Contribute to dav1dcg/spikesandbursts development by creating an account on GitHub.

Understanding how the brain represents experienced time and how representations of space and time are integrated to form episodic memories has been a goal of much neuroscientific research. In this Per...

A high-resolution transcriptomic and epigenomic cell-type atlas of the developing mouse visual cortex from embryonic to postnatal development is presented, providing a real-time dynamic molecular map ...

Rapid eye movement (REM) sleep is a unique state classically defined by brain activation and muscle paralysis. It is now recognized as a dynamic process involving coordinated oscillations and phasic b...

Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...

Despite recent advances in green genetically encoded ion indicators, developments in red-shifted indicators have been slower. This Primer explores two recent studies in PLOS Biology that engineer red ...

Job #AJO30961, Assistant Professor in Biology and Neuroscience Program, Biology Department, Brandeis University, Waltham, Massachusetts, US

Code from the neuroscience blog Spikes and Bursts. Contribute to dav1dcg/spikesandbursts development by creating an account on GitHub.