iiinova — where your digital self keeps evolving

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Mittal Group @ TAMU @mittalgrouptamu.bsky.social · 30/09/2026

(Part 1/2) Excited to share our recent work with Prof. Nicolas Fawzi’s group (nicolasluxfawzi.bsky.social), now out in Angewandte Chemie (onlinelibrary.wiley.com/doi/full/10....)! We show how RNA reshapes FUS condensate assembly and dynamics. Congrats to Tongyin, Kandarp, Samara, Qizan, Priyesh!

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Mittal Group @ TAMU @mittalgrouptamu.bsky.social · 16/09/2026

(Part 1/2) Excited to share our latest paper (doi.org/10.1063/5.03...), led by PhD student Shuo-Lin Weng and Dr. Shiv Rekhi! We introduce buffered Charge-Regulation Monte Carlo method to model dynamic charge regulation, buffer equilibria, and ion partitioning within condensates.

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Biophysical Society @biophysicalsoc.bsky.social · 08/08/2026

The #bps2027 Biophysical Society Lecturer is Susan Marqusee, University of California, Berkeley. Don't miss her talk, "Touring the Energy Landscape" at the Annual Meeting in Philadelphia on Monday, February 22. See you there!

buff.ly

2027 Biophysical Society Lecture | Biophysical Society

University of California, Berkeley

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Nicolas Lux Fawzi @nicolasluxfawzi.bsky.social · 29/07/2026

New from Fawzi + @mittalgrouptamu.bsky.social labs led by Busra Ozguney and Ryan Puterbaugh. Methionine oxidation in both helical conserved region and disordered regions of TDP-43 C-terminal domain decreases phase separation by perturbing different sets of contacts www.pnas.org/doi/10.1073/...

pnas.org

Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-terminal domain phase separation | PNAS

TAR DNA binding protein 43 (TDP-43), a key protein linked to ALS pathology, undergoes phase separation and forms functional assemblies via condensa...

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Rohit V. Pappu @rohitpappu68.bsky.social · 26/07/2026

We show, in collaboration with Yifan Dai, that biomolecular condensates function as inherent catalysts. Interphase potentials give rise to electric fields at the interfaces of condensates that are tunable, strong enough to align substrates, & function as electro catalysts. doi.org/10.1016/j.mo...

doi.org

Redirecting

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Souradip Paul @indiasouradip.bsky.social · 07/07/2026

Formative work on engineered RNA condensate.

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Marqusee Lab @marquseelab.bsky.social · 05/07/2026

Congrats to our talented postdoc @amirbitran.bsky.social for his first preprint in the lab, a collaboration with the Bustamante lab, studying time-resolved protein folding during translation elongation with HDX-MS! Check out the attached manuscript and tutorial for more:

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 07/07/2026

Our new preprint @biorxivpreprint.bsky.social, led by @katsuminami.bsky.social‬ et al.! 🎉 www.biorxiv.org/content/10.6... Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.

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Souradip Paul @indiasouradip.bsky.social · 30/06/2026

Thank you Biopatrika for featuring our study.

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Anders Sejr Hansen @andersshansen.bsky.social · 22/06/2026

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

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Anita Donlic @anitadonlic.bsky.social · 05/06/2026

Thrilled to see our Deep-Phase paper now online in @cellcellpress.bsky.social! 🎉 The final version expands Deep-Phase across labeling modalities, adds dual-condensate imaging to dissect pathway specificity, and shows greater robustness to batch effects than classical image-analysis methods.

cell.com

Deep learning of functional perturbations from condensate morphology

A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral condensate morphology to reveal underlying biochemical states. Applying this framework reveals a previously unrecogn...

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Wilfling Lab @wilflinglab.bsky.social · 20/01/2026

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 01/05/2026

Our new preprint! 🧬✨ www.biorxiv.org/cgi/content/... @ynagata.bsky.social et al. combined single-nucleosome imaging with Fucci probes to follow local chromatin behavior during interphase. Local nucleosome motion stays nearly constant from G1 to G2, except in early G1. Thanks to all coauthors!

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Mahipal Ganji @ganjilab.bsky.social · 26/04/2026

Our latest paper is online. www.nature.com/articles/s41... We expanded the speed-optimized DNA-PAINT sequences from 6 to 12 — enabling faster, higher-resolution multiplexed super-resolution imaging of up to 10 cellular targets. Here's the story. 1/n

nature.com

High-speed multiplexed DNA-PAINT imaging of nuclear organization using an expanded sequence repertoire - Nature Communications

Banerjee, Anand, and colleagues present an expanded speed-optimized DNA-PAINT sequence repertoire. This repertoire allows for improved multiplexing capability in super-resolution imaging, maintaining ...

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 08/04/2026

Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

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Sjors Scheres @sjorsscheres.bsky.social · 02/04/2026

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...

biorxiv.org

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Heilemann Lab @heilemannlab.bsky.social · 16/03/2026

DNA-PAINT with photocaged DNA labels = PhotoPAINT🔬. Why? No need for washing or mixing 👉🏻 higher accuracy in DNA-PAINT & other super-res methods. Fantastic collab with Alex Heckel & driven by the 'magic team' Nina Kaltenschnee and Marina Dietz 💪 doi.org/10.1002/anie... @goetheuni.bsky.social

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xavier salvatella @xsalvatella1.bsky.social · 16/03/2026

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

science.org

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

The druggability of intrinsically disordered regions.

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Michał Małszycki @malszycki.bsky.social · 25/02/2026

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Graphical abstract: Speckle-proximal and speckle-dependent RNA has short introns, and simultaneous emergence of multiple exons requires heightened concentration of spliceosome components.
Speckle-independent RNA has long introns and can be spliced well with or without speckles
Speckle dependent introns evolved in amniotes. The reduction in intron length was accompanied by the increase of the intronic GC content, giving rise to GC-levelled intronic architecture. This exon-intron architecture is not present outside of amniotes (Fish, Invertebrates), and these organisms lack nuclear speckles.

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Wilfling Lab @wilflinglab.bsky.social · 13/01/2026

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

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Zwicker Group @zwickergroup.bsky.social · 08/01/2026

Our "Roadmap for Condensates in Cell Biology" is now available on arXiv: arxiv.org/abs/2601.03677 🎉 This article summarizes the interdisciplinary weekly discussions we had at our condensate workshop at KITP in the summer of 2025. Feedback is very welcome!

arxiv.org

Roadmap for Condensates in Cell Biology

Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting t...

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 28/08/2025

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

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Zwicker Group @zwickergroup.bsky.social · 21/11/2025

Our review on the physics of phase separation in cells has been published by Rep. Prog. Phys. 🎉 doi.org/10.1088/1361... We hope that the text and citations are helpful for anyone interested in physical descriptions of condensates in cells!

doi.org

Physics of droplet regulation in biological cells - IOPscience

Physics of droplet regulation in biological cells, Zwicker, David, Paulin, Oliver W, ter Burg, Cathelijne

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