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Claire Wyart @clairewyart.bsky.social · 26/08/2025

Motor Folks: a nice opportunity to present your work & get feedback! BTW registration to the Conference "Searching Principles in Motor Control" on Sept 23-24, 25 is free but mandatory, please sign up and present your work to the French community ! motorconference.sciencesconf.org?lang=en

motorconference.sciencesconf.org

Searching for Principles in Motor Control - Sciencesconf.org

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Claire Wyart @clairewyart.bsky.social · 20/08/2025

Hey #motorcontrol researchers! @jul-bouvier.bsky.social, LeMouel & I organize *Searching for principles in Motor Control* Paris Sept 23-24, 25 @sorbonne-universite.fr @institutducerveau.bsky.social @neuropsi.bsky.social: Submit Abstract for Posters by Aug 31! motorconference.sciencesconf.org?lang=en

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Claire Wyart @clairewyart.bsky.social · 12/07/2025

We work on humans with @antoniocbscosta.bsky.social @marcoromanato.bsky.social @wyartlab.bsky.social predicting effects of #DBS in Parkinson's Disease patients. Yet, understanding cellular & circuit mechanisms underlying behaviour require model organisms 🎏🐭🪱🪰 & cannot be done in humans nor organoids

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International Zebrafish Society @izfs.bsky.social · 11/07/2025

Congratulations to the 2025 George Streisinger Award Winners! And, thank you, to your contributions to the #zebrafish field! #IZFC2025

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Camp Lab @graycamplab.bsky.social · 11/07/2025

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

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eLife @elife.bsky.social · 11/07/2025

Chronic back pain affects most of us eventually, and ageing discs are often to blame. But cellular senescence may not be irreversible. This Insight Article explores how platelet-derived growth factors could help revive ageing disc cells. buff.ly/VjINkon

buff.ly

Senescence: Returning aging cells to productivity

Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.

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Ferenc Mueller @ferencmueller.bsky.social · 11/07/2025

Dear #izfc2025 participants, if anyone of you are interested in how transcription control defines mRNA fate and translation in zebrafish development, there are/will be several PhD and postdoctoral positions (funded by the Wellcome Trust) for this research. Please find me if interested.

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Shawn Burgess @burgesslab.bsky.social · 12/07/2025

Ferenc is great, super opportunity!

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Kristen Kwan @blockintheback.bsky.social · 11/07/2025

The winners of the 2025 George Streisinger Award are the Course Directors of the Zebrafish Development and Genetics course at MBL, for their tremendous contributions to our amazing community for >25 years! #izfc2025

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@LaBonneLaB @labonnelab.bsky.social · 11/07/2025

Dear all, PLEASE add comments on the importance of model organism research at this link:

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Jeremy Berg @jeremymberg.bsky.social · 12/07/2025

NIH suspending or terminating grants with a very broad definition of dangerous gain of function research (which appears to include standard safe laboratory procedures) www.science.org/content/arti...

science.org

Exclusive: NIH suspends dozens of pathogen studies over ‘gain-of-function’ concerns

Trump executive order leads to pauses on U.S.-funded research into TB, influenza, COVID-19, and other diseases, dismaying some scientists

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animal prattle @animal-prattle.bsky.social · 11/07/2025

V cool work from @ebriefer.bsky.social et al on how selection for sociability alters vocal signals (in sheep!) bit.ly/40AHKTd 1. Isolation but not feeding calls distinguish 🐑 selected for high vs low sociability 2. More selection for sociability ➡️ Less vocal individuality #prattle 💬 #bioacoustics

Figure 1: Acoustic differences in isolation bleats (left side of panel) and in pre-feeding bleats (right side of panel) according to the ‘line’ (S+, S- and intermediate not selected when considering the isolation calls). A: Spectrogram of calls of one representative S+ female and one representative S- female according to the context of recording (FFT wl = 2048 pts, ov=90%, frequency sampling=44.1 kHz, amplitude range from blue to red color scale: -70 to 0dB). B: Averaged mean-spectrum (and standard deviation in shade) over the total amount of calls analyzed per line and contexts (Number of isolation calls: N=322 from S+, N=67 from S-, N=899 from not selected females; Number of pre-feeding calls: N=262 from S+, N=257 from S- females). C: Acoustic parameters explaining the Acoustic Score computed using a LDA on ‘line’ within
each context of recording (isoLD for isolation and pre-feedLD for pre-feeding). For isolation calls, the predictions of isoLD for calls recorded in non-selected females and comparisons (groups with different letters illustrate statistical differences, see supplementary statistical tables S3 for model estimates and pairwise comparisons).

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Benjamin Judkewitz @benjulab.bsky.social · 12/05/2025

Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...

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Gonzalo de Polavieja @polavieja.bsky.social · 03/06/2025

It took us many years to improve idtracker.ai in both accuracy and tracking time. Here it is.

idtracker.ai

idtracker.ai — idtrackerai 6.0.3 documentation

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Wyart Lab @wyartlab.bsky.social · 02/07/2025

Downstream @etlunsford.bsky.social mapped how the corresponding interneurons in the brainstem project onto reticulospinal neurons to select the steering command eliciting either forward or turns ... recalling the pioneering work of @daniobrain.bsky.social on optical motor response to flow! (5)

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Wyart Lab @wyartlab.bsky.social · 02/07/2025

The tackle this question, @etlunsford.bsky.social 🌬️ stimulated each & all neuromasts along the body & discovered a simple principle within the brainstem !! Namely, information on location & direction is encoded in an egocentric referential around the center of mass! www.biorxiv.org/content/10.1...

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Wyart Lab @wyartlab.bsky.social · 02/07/2025

Fish display mechanosensors called neuromasts covering their body from head to tail. In each neuromast, hair cells can sense changes in water flow along different directions in the anteroposterior axis, either tailward or headward. How does the brain compute the flow information across the body? (2)

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Wyart Lab @wyartlab.bsky.social · 02/07/2025

By combining controlled mechanical stimulation & whole brain #imaging, @etlunsford.bsky.social revealed an essential principle 💡... Mechanosensory inputs from any directions along the body are encoded relative to the center of mass (COM)! Recalling #olfaction with odors encoded by pleasantness (4)

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Wyart Lab @wyartlab.bsky.social · 02/07/2025

Let's share @etlunsford.bsky.social's work : to survive, animals avoid drifting involuntarily in their environment. While humans rely on visual & vestibular cues, birds & fish need to sense complex flow changes of the external fluid (air/water) around them to select motor actions. How do they do?(1)

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Claire Wyart @clairewyart.bsky.social · 02/07/2025

hi BlueSky, introducing @wyartlab.bsky.social @zebrafishrock.bsky.social "cuvée" 🍷 biodynamic organic & bubbly 2025!! Located in @institutducerveau.bsky.social 🎏 migrating in summer @sorbonne-universite.fr to observatory or in @standrewspsyneuro.bsky.social to learn #MotorControl, #morphogenesis!

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Claire Wyart @clairewyart.bsky.social · 12/06/2025

⚡Awesome days of scientific discussions around the topic of resilient motor circuits in Parkinson's disease & underlying genetic conditions featuring Prof. Alexis Brice, Leonard Constien, Ananelle Redon, Ninon Peysson @kevinfidelin.bsky.social among others⚡

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kevinfidelin.bsky.social @kevinfidelin.bsky.social · 12/06/2025

🚨Job opportunity 🚨 The @clairewyart.bsky.social 's lab, at the @institutducerveau.bsky.social is looking for a lab manager to help us cracking the molecular underpinnings of motor circuits in vivo and across species !

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Claire Wyart @clairewyart.bsky.social · 12/06/2025

🧿 Excited about molecular biology & genetics 🧬🧬🧬? Wanna live in Paris? Join our team as a lab manager under the supervision of @kevinfidelin.bsky.social & myself! Personal development in professional environment is our mission. Inclusive space where proactive and playing collective people flourish 🧿

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Claire Wyart @clairewyart.bsky.social · 17/03/2025

Great seminar this morning scheduled this morning from Andre Brown @imperialcollegeldn.bsky.social @institutducerveau.bsky.social dont miss it !

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Claire Wyart @clairewyart.bsky.social · 14/12/2024

Congrats Laura, your science (and neuronal morphologies) is (are) beautiful ✨🌳

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Claire Wyart @clairewyart.bsky.social · 01/12/2024

Motor afficionados: Don't miss great talks coming up this week #CAJAL #Training @univbordeaux.bsky.social #MotorControl featuring in particular @olekiehn.bsky.social #FENS president & Brain Prize 2022 showing his contribution to understanding *Circuits for Movements* on Thursday Dec 5th at 11 AM ✨

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Tasia Asakawa @tasiaasakawa.bsky.social · 27/11/2024

The Nordic #neuroscience societies welcome you all to the FENS Regional Meeting in Oslo next year - the first time ever in a Nordic country! The CALL FOR SYMPOSIA is still open until 30 November. Submit now! frm2025oslo.no #FRM2025 #brain #FENS @pirtahotulainen.bsky.social @olekiehn.bsky.social

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Claire Wyart @clairewyart.bsky.social · 01/12/2024

Congrats @adrienjouary.bsky.social @daniobrain.bsky.social !! beautiful use of AI to automate the categorisation of single locomotor bouts of #zebrafish, following the pioneering work of João Marques. Well done!

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Claire Wyart @clairewyart.bsky.social · 21/11/2024

So MUCH fun organizing the Cajal Brain Prize Motor School in the honour of Silvia Arber, Martyn Goulding and Ole Kiehn for 20 early career students and postdocs wanting to learn by making their hands dirty when comparing 🐸🎏 🐭🐒 🚶‍♂️locusts, frogs, fish, mice, macaques, humans and more!

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Claire Wyart @clairewyart.bsky.social · 16/11/2024

📣 Time to register to the 7th European Zebra 🐟 Principle Investigator Meeting to be held in Paris Brain Institute, April 2- 5, 2025. Early 🦜 until Dec 15th, 2024. Abstract submission is now open. Apply! Share latest results & fun ! 👉 lnkd.in/e4pDe7uh #zebrafish www.europeanzebrafishpimeeting.com

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Claire Wyart @clairewyart.bsky.social · 16/11/2024

Individuality is fascinating. We found how to quantify variability among individuals by identifying long-lasting motor strategies during navigation. Work of Dr. Gautam Sridhar and Dr. Antonio Costa in collab with João Marques @daniobrain.bsky.social out today in #PNAS ! www.pnas.org/doi/10.1073/...

When animals deploy motor strategies to navigate and adapt to changing environments and their own experiences, their behavior is highly variable across multiple timescales and from one animal to another. Using high-fidelity Markov models of behavior, we reveal the main modes along which zebrafish generate motor strategies in different environments. We uncover essential principles underlying navigation and reveal that an individual’s past experience, or its current inner state alters preferences for long-lasting motor strategies. This study sets the stage for general approaches to dissect the origin of variability of navigation among individuals.

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To reveal structure in individual variability, we build Markov models of action sequences that bridge across timescales and enable the comparison of behavioral phenotypes among individuals. Applied to zebrafish responding to diverse sensory cues, we uncover a hierarchy of long-lived motor strategies, dominated by changes in orientation distinguishing cruising versus wandering. While fish cruise in the light, they wander in response to aversive stimuli, or in search for appetitive prey. As our method encodes the behavioral dynamics of each individual fish in the transitions among coarse-grained motor strategies, we use it to uncover a hierarchical structure in the phenotypic variability that reflects exploration–exploitation trade-offs. The major source of variation among fish is driven by prior or immediate exposure to prey that induces exploitation phenotypes. A large degree of variability not explained by environmental cues unravels hidden states that override the sensory context to induce contrasting exploration–exploitation phenotypes. Altogether, by extracting the timescales of motor strategies deployed during navigation, our approach exposes structure among individuals and reveals internal states tuned by prior experience.

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