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Helen Brabham

@helenbrabs.bsky.social
703 followers 770 following 21 posts

(she/her) Working in the wonderful world of plant disease resistance. 🌾🏴󠁧󠁢󠁷󠁬󠁳󠁿 Team Leader at Gatsby, The Sainsbury Laboratory, Norwich, UK.

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Helen Brabham @helenbrabs.bsky.social · 28/09/2026
Gb3 encodes a unique kinase fusion protein conferring greenbug resistance in wheat www.nature.com/articles/s41...
nature.com
Gb3 encodes a unique kinase fusion protein conferring greenbug resistance in wheat - Nature Genetics
Gb3 encodes an intracellular kinase–pseudokinase protein with a unique MAP3K-like domain that confers resistance to multiple greenbug biotypes in wheat.
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Greg Vert @plantubiquitin.bsky.social · 27/09/2026
Synthetic FLS2 receptor oligomer boosts plant innate immunity | Science Advances www.science.org/doi/10.1126/...
science.org
Synthetic FLS2 receptor oligomer boosts plant innate immunity
The gradual assembly and oligomerization of cell surface receptors are critical for regulating immune activation and turnover. Yet, how dynamic, spatiotemporally regulated assembly enables rapid and s...
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Guavadk @guavadk.bsky.social · 09/09/2026
🍄 We investigated conserved cytoplasmic effectors in Fusarium as targets for resistance breeding. Our harmonized annotation dataset for 305 Fusarium genomes is now on Zenodo. 📌 Poster: doi.org/10.5281/zenodo.22649574 📦 Dataset: doi.org/10.5281/zenodo.22224641 #PPATH2026
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Stefan Schoenfelder @stefanschoenfelder.bsky.social · 09/09/2026
www.nature.com/articles/d41...: "...the results are a wake-up call for scientists developing biological-AI tools: they underscore the need for more rigorous performance benchmarks and for much more experimental data relating genetic sequences to biology."
nature.com
Mutating every DNA letter of a genome shows surprising effects — and the limits of AI
Top artificial-intelligence models failed to predict the biological consequences of rewriting a virus's entire DNA code.
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Mariana Schuster @marischuster.bsky.social · 07/09/2026
I'm excited to share that my newly funded #ERCStG FRONTERA is recruiting two postdoctoral researchers at @ipbhalle.bsky.social 🌱🔬 If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵 Please RT/share!
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Sam Mugford @samtmugford.bsky.social · 12/08/2026
New pre-print from the @saskiahogenhout.bsky.social lab We (@qunliu07.bsky.social et al.) show that the aphid effector protein CathB6, in addition to suppressing plant immunity via EDS1, also alters the regulation of chloroplast-nuclear signalling to maintain photosynthetic gene expression. 1/n
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Etienne Bucher 🌾🧬🇪🇺 @plantepigenetics.ch · 09/08/2026
❗ French agriculture is experiencing one of the worst nationwide agricultural disasters since 1945 due to drought. 🔻 corn -41% 🔻 sorghum - 61% (promoted as drought tolerant! 🤔 ) 🔻 wheat -31% 🔻 potato -42% 🔻 legumes -30 to -70% A huge challenge for all. www.linkedin.com/feed/update/...
linkedin.com
La situation agricole française n’est plus au bord du gouffre, comme elle pouvait l’être en 2022 : cette fois-ci, elle est dans le gouffre. Il n’est désormais plus inconcevable que nous soyons en… | S...
La situation agricole française n’est plus au bord du gouffre, comme elle pouvait l’être en 2022 : cette fois-ci, elle est dans le gouffre. Il n’est désormais plus inconcevable que nous soyons en trai...
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Genome Biology and Evolution @genomebiolevol.bsky.social · 11/08/2026
@loreament.bsky.social & Saupe suggest that fungal NOD-like receptors evolve under diversity-enhancing mechanisms and display selective signatures consistent with a general immune function. 🔗 doi.org/10.1093/gbe/... #societyjournal #genome #evolution
doi.org
NOD-Like Receptor Genes Undergo Diversity-Enhancing Evolution in a Fungal Species Complex
Abstract. Fungi harbor diverse arrays of genes encoding NOD-like receptors (NLRs), key intracellular immune proteins found in plants, animals, and bacteria
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Jeff Groh @jeffgroh.bsky.social · 28/07/2026
Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...
pnas.org
Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS
In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...
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KWS Group @kwsgroup.bsky.social · 27/07/2026
Job opportunity! 🌱 At KWS Einbeck (Germany), we have an exciting opening for a Group Lead for Molecular Trait Analysis & Genomics. 👉 Read more & apply online: jobs.kws.com/job/Einbeck-...
jobs.kws.com
Group Lead (m/f/d) for Molecular Trait Analysis and Genomics
Group Lead (m/f/d) for Molecular Trait Analysis and Genomics
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Plant Science Spotlight @plant-sci.bsky.social · 23/07/2026
🌍🌾Global hunger dropped to 645 million in 2025, but progress is slow & uneven. Africa remains the hardest hit, with over half facing food insecurity. FAO urges faster investment & stronger agrifood systems Progress is possible, but not guaranteed #plantscience @fao.org www.isaaa.org/kc/cropbiote...
isaaa.org
UN Releases Global Report on the State of Food Security and Nutrition
The number of hungry individuals continues to decrease for the third year in a row, showing progress is attainable. However, the progress recorded was unstable, unevenly distributed, and insufficient ...
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Toby Baril @tobybarilbio.bsky.social · 24/07/2026
Huge congrats to @alicelaigle.bsky.social for driving this work - excited to share this preprint! Comparative analyses reveal rapid turnover and emergence of transitory 3D genome architectures in the fungal kingdom www.biorxiv.org/content/10.6... #fungi #bioinformatics #evolution #preprint
biorxiv.org
Comparative analyses reveal rapid turnover and emergence of transitory 3D genome architectures in the fungal kingdom
The three-dimensional architecture of genomes plays major roles in biological processes such as gene expression and DNA replication. The architecture of genomes has evolved substantially with distinct...
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Plant Science Spotlight @plant-sci.bsky.social · 24/07/2026
🧬🌾IDRs can restrain chromatin regulators, not just enable them. Deleting ALKBH5's IDR redirects it to chromatin, boosting root growth in Arabidopsis & rice yield A conserved mechanism with breeding promise #plantscience @natgenet.nature.com @plantresearch.bsky.social www.nature.com/articles/s41...
nature.com
Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants - Nature Genetics
Intrinsically disordered regions impose regulatory restraints on gene-activating demethylases, limiting chromatin engagement and preserving genomic stability. This function is a key determinant of the...
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Plant Science Spotlight @plant-sci.bsky.social · 24/07/2026
🧬🌾Synthetic plant immune receptors (SPIRs) can be programmed to recognize viral, bacterial, fungal, and oomycete proteins. AI-guided design and in planta evolution boost specificity and activity. Transgenic plants with SPIRs showed disease resistance. #plantscience www.science.org/doi/10.1126/...
science.org
Programmable design of synthetic plant immune receptors for pathogen protein recognition
The limited diversity and recognition scope of natural plant immune receptors impede resistance breeding against rapidly evolving pathogens. Here we report programmable design of synthetic plant immun...
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 15/07/2026
Time-dependent transcriptomic changes following protoplast isolation in plants www.biorxiv.org/content/10.64898/20…
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Ralph Hückelhoven @huckelhovenr.bsky.social · 15/07/2026
A tomato MIK2‐clade receptor is involved in the perception of a Fusarium‐derived elicitor - Maroschek - New Phytologist - Wiley Online Library nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com
A tomato <fc>MIK2</fc>‐clade receptor is involved in the perception of a <fi>Fusarium</fi>‐derived elicitor
Fusarium elicitor responsivness and MIK2-clade proteins are conserved across plant families.
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Nick Talbot @talbotlabtsl.bsky.social · 13/07/2026
Excited to preprint this collaborative study led by @adamrbentham.bsky.social in which computationally-designed protein binders were generated that recognise pathogen effectors leading to a plant immune response when deployed within NLR immune receptors. www.biorxiv.org/content/10.6...
biorxiv.org
Computational design of de novo integrated domains enables rational control of pathogen effector recognition in plant NLR immune receptors.
The rapid evolution of plant pathogens poses a persistent threat to global agricultural sustainability, often outpacing the discovery and deployment of natural disease resistance genes. While bioengin...
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Cambridge Biochemistry @cambiochem.bsky.social · 08/07/2026
New @cam.ac.uk feature on the wonderful work in the Howe Lab to develop biocells that harness the chemistry of algae to power small devices: www.cam.ac.uk/stories/camb...
cam.ac.uk
A truly green way to power our devices
At a time when ‘being green’ matters more than ever, a team of Cambridge researchers has devised a way to power electronic devices that’s taken the brief quite literally.
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Herranz Lab @herranzlab.bsky.social · 09/07/2026
Who would have guessed!? 🙄 www.nature.com/articles/d41...
nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 24/06/2026
Our latest work on immune receptor engineering for enhanced pathogen recognition is out in @theplantcell.bsky.social academic.oup.com/plcell/artic... #NLRs #Effectors #Exo70
academic.oup.com
Engineering an Exo70 integrated domain of a barley NLR for improved blast resistance
Engineering the barley NLR RGH2 enhances recognition of blast pathogen effectors from rice and wheat, leading to improved disease resistance.
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Jessica Lee Erickson @ericksonlab.bsky.social · 23/06/2026
New Preprint! We identified 20 new type II-secreted effectors from Xanthomonas euvesicatoria and show that they help bacteria feed and remodel plant cell walls during infection. Proud of my team at #ZMBP and collaborators for making this possible! www.biorxiv.org/content/10.6...
biorxiv.org
Defining the Xanthomonas euvesicatoria type II-secreted effector arsenal: core nutritional functions and effector diversity
The type II secretion (T2S) system is conserved across the Xanthomonas lineage, yet its contributions to pathogenicity and secreted protein repertoires are poorly defined. We demonstrate that T2S syst...
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John Manners @jmaus.bsky.social · 23/06/2026
A mind-bending application of AI and AI agents to develop and interrogate plant development and response networks by accessing all historical literature on plant gene functions. A staggering AI tour de force from the UQ node of @coeplantsuccess.bsky.social 🧪 #plantscience sciety.org/articles/act...
sciety.org
FLASH-P: Turning decades of biology into accurate causal networks with AI agents
Mechanistic networks that encode causal regulatory logic can predict the effects of genetic and environmental perturbations but constructing them is a bottleneck in systems biology because the relevan...
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wenchangyue.bsky.social @wenchangyue.bsky.social · 17/06/2026
10 colour palettes I reach for in research charts — curated, and most are colourblind-safe. Categorical + sequential: Okabe-Ito, Paul Tol, Tableau 10, viridis, cividis, magma. Skip default tab10 and rainbow/jet. Which do you swear by? Anything I'm missing? #DataViz #ColorPalette #SciComm
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Olivier Borkowski @oborkowski.bsky.social · 18/06/2026
Paradoxical gene regulation explained by competition for genomic sites doi.org/10.1101/2025...
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Mary Williams @PlantTeaching @plantteaching.bsky.social · 18/06/2026
I absolutely love BHL! @biodivlibrary.bsky.social Here's an article from 2014 about my love for it, with links to classics in plant physiology 💚 blog.biodiversitylibrary.org/2014/10/expl... And the treasures and drawings it holds are AI-free 😀 PS - I just donated to support it.
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Plant Science Spotlight @plant-sci.bsky.social · 15/06/2026
🌾🧬Immune receptor MLA3 mimics a pathogen target to detect effectors. Engineered SR50 recognizes two cereal pathogens in barley. A strategy for multiple disease resistance #plantscience @dianagdlc.bsky.social @talbotlabtsl.bsky.social @thesainsburylab.bsky.social www.science.org/doi/10.1126/...
science.org
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
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Plant Science Spotlight @plant-sci.bsky.social · 13/06/2026
Don’t reach for ChatGPT Images or Nano Banana as your first option when creating scientific images There are multiple free and open-source images, icons, and tools for creating scientific illustrations. #plantscience @stephenturner.us blog.stephenturner.us/p/free-open-...
blog.stephenturner.us
Free and open-source images, icons, and tools for creating scientific illustrations
Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics
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New Phytologist @newphyt.bsky.social · 02/06/2026
Potential unlocked: an atlas of cloned wheat genes for genome engineering and breeding 🌾 A #TansleyInsight by Abdulrahman Alhabsi, et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
Strategies for introducing genome edits into a wheat breeding program and their effects on cultivar longevity.
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Plant Science Spotlight @plant-sci.bsky.social · 01/06/2026
🌿🧬 Large duplications create overlapping expression. Small duplications create asymmetric divergence. Dosage sensitive genes stay conserved #plantscience @theplantcell.bsky.social @almeidasilvaf.bsky.social @yvdp.bsky.social @aspbofficial.bsky.social academic.oup.com/plcell/artic...
academic.oup.com
Gene expression divergence following gene and genome duplications in spatially resolved plant transcriptomes
After gene and genome duplications, expression divergence across cell types is not random, and it can be explained by a combination of gene age, gene funct
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Dan the Gnome @brewergnome.bsky.social · 01/06/2026
From outside, basic research looks like "a waste" like meaningless navel gazing to understand stuff that "doesn't matter to the average person." Read this thread to see how smushing jellyfish through cheesecloth has literally overturned what's possible in biology and medicine.
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Team_Zuccaro @algazuccaro.bsky.social · 20/05/2026
Proud to share our new paper on how prion-like fungal effectors target plastids and modulate host metabolism during root symbiosis. Exciting collaborative work uncovering PEPSI effectors and the interaction of one of them with DXR in plants. www.biorxiv.org/content/10.6... bsky.app/profile/eell...
biorxiv.org
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 21/05/2026
Host specificity in cereal rust fungi is mediated by a conserved glycoside hydrolase family www.biorxiv.org/content/10.64898/20…
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Nature Portfolio @natureportfolio.nature.com · 19/05/2026
Two papers in Nature present AI systems that can assist throughout multiple processes involved in scientific research. The systems are designed to assist researchers in accelerating scientific discovery, not to replace them. go.nature.com/4tFHspz go.nature.com/3RQzXyL #Academicsky 🧪
This is figure 1, which shows Co-Scientist design, multi-agent architecture, and experimental validation summary.
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Duncan Coleman @duncan-coleman.bsky.social · 23/04/2026
How do plants respond to wounding? Well it it's not too dissimilar to how they respond to heat. We found that plants utilize the HSFA1 transcription factors to rapidly induce wound-induced regeneration genes after injury. @keikosugimoto.bsky.social @deveylderlab.bsky.social @wigge.bsky.social
doi.org
Wounding activates the HSFA1 transcription factors to promote cellular reprogramming in Arabidopsis
The HEAT SHOCK FACTOR A1 transcription factors rapidly accumulate in the nucleus after wounding and directly activate regenerative pathways in plants.
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 19/05/2026
Colletotrichum higginsianum effector ChEC108 binds a plasmodesmal HMA protein and elicits plant defence www.biorxiv.org/content/10.64898/20…
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Genome Biology and Evolution @genomebiolevol.bsky.social · 18/05/2026
brettadey.bsky.social @ppgardne.bsky.social et al. estimate background transcription in the human genome, finding low levels of background transcription and suggesting that most transcription is not a consequence of background noise. 🔗 doi.org/10.1093/gbe/evag042 #genome #evolution
GBE | Pervasive Transcription in the Human Genome Exceeds Background Noise
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 18/05/2026
Generation of promoters enabling high-level constitutive gene expression in both plants and Escherichia coli www.biorxiv.org/content/10.64898/20…
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bioRxivpreprint @biorxivpreprint.bsky.social · 11/05/2026
The variable wheat stripe rust effector AvrYr7 evades Yr7 recognition through sequence and expression polymorphisms www.biorxiv.org/content/10.64898/20…
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Marion C. Müller @marioncmueller.bsky.social · 05/05/2026
Super excited to see our work on the Pm3e NLR that recognises two structurally diverse AVR effectors from powdery mildew out in @natcomms.nature.com Congratulations to @lukas-kunz.bsky.social, Beat Keller, and everyone involved! Check it out ➡️https://www.nature.com/articles/s41467-026-72199-w
nature.com
Dual recognition of structurally unrelated mildew effectors underlies the broad-spectrum resistance of Pm3e in wheat - Nature Communications
The wheat NLR Pm3e provides broad-spectrum resistance against powdery mildew. Here, the authors show that Pm3e recognizes two structurally unrelated effector proteins and that its range can be further...
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Nature Human Behaviour @nathumbehav.nature.com · 01/05/2026
How to design effective scientific figures
dlvr.it
How to design effective scientific figures
Nature Human Behaviour, Published online: 01 May 2026; doi:10.1038/s41562-026-02466-9Scientific figures strongly influence how research findings are interpreted, yet guidance on figure design has largely focused on technical aspects of visualization. In this ‘How to’ Comment, I outline a practical strategy for creating figures that communicate clearly across audiences and scientific contexts.
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Doudna Lab @doudna-lab.bsky.social · 27/04/2026
We present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR. Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex.
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Helen Brabham @helenbrabs.bsky.social · 27/04/2026
k-mer-based approaches to unlock genebank genomics for targeted crop improvement rdcu.be/ffBWh
rdcu.be
k-mer-based approaches to unlock genebank genomics for targeted crop improvement
Nature Genetics - Genebanks hold untapped genetic diversity for crop improvement. Using k-mer-based approaches to map allele and haplotype diversity enables the selection of user-defined core...
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Trends in Plant Science @cp-trendsplantsci.bsky.social · 14/04/2026
Deflecting the parasitic paradigm: new insights into mutualistic transposons in plant genomes #plantscience
dlvr.it
Deflecting the parasitic paradigm: new insights into mutualistic transposons in plant genomes
Inherited transposable elements (TEs) embedded in genomes have an incomparable potential for large-effect mutagenesis. Notwithstanding that transposable elements can be destructive when mobile, it is undeniable that some beneficial effects arise as well. From a population-level perspective, de novo genetic variation arising from TE transposition endows species with increased potential to colonize and thrive in extremely diverse environments. With an emphasis on plant genomes, this review provides an overview of recent insights into functional transpositions and the mechanisms behind them. We will discuss the underappreciated application prospects of mobile elements as prominent endogenous mutagens through recent evidence of transposition-induced phenotypic variation. These novel findings suggest a shift away from the view of TEs as solely parasitic entities and advocate for a more mutualistic role.
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Joram Dongus @drdongus.bsky.social · 14/04/2026
New bioRxiv preprint!🌱 We found the SAUERKRAUT transposon to regulate the floral transition in a salt-dependent manner!🧂 A step toward salt-tolerant crops in a changing climate!🌞🥬 🔗 doi.org/10.64898/202... #PlantScience #SaltStress #ClimateChange @pph-wur.bsky.social @christatesterink.bsky.social
Salt stress alters plant development, including the floral transition, but regulation of timing of flowering by salt is poorly understood at the molecular level. To identify genetic loci regulating the floral transition under high soil salinity, we performed a genome-wide association study (GWAS) in Arabidopsis thaliana and identified natural variation at the UGT74E1-UGT74E2-BT3 (UUB) locus that correlates with bolting time specifically in response to salt stress. Genetic analysis revealed BT3 as a novel repressor of the floral transition in control conditions. Similarly, the putative IBA glycosylases UGT74E1 & UGT74E2 delay the floral transition in control conditions. Furthermore, we identified that IBA homeostasis regulators TOB1 and ECH2/IBR10 play a key role in the floral transition, and that ECH2/IBR10 are required for the early flowering phenotype of the ugt74e1/ugt74e2 double mutant, indicating that UGT74E1 & UGT74E2 delay flowering by altering IBA homeostasis. A pangenome analysis of the UUB locus revealed variation in the occurrence of the DNA transposon SAUERKRAUT (SKRT). CRISPR-mediated SKRT deletion in Col-0 affected gene expression both within and outside the UUB locus and caused a salt-dependent delayed floral transition. The delayed bolting phenotype of the skrt-2 mutant also depends on ECH2/IBR10 function, indicating that SKRT accelerates the floral transition by altering IBA homeostasis. Finally, targeted demethylation of SKRT resulted in delayed floral transition under salt stress. Taken together, our data show a role for SKRT and its DNA methylation levels in the salt-dependent bolting time response in Arabidopsis, revealing a novel molecular mechanism to control flowering in adverse conditions.
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Tuna @antea04.bsky.social · 10/04/2026
I'm a data scientist @ourworldindata.org and I need help from a botanist or someone local to Kyoto, Japan! 🌸 We present one of the world’s longest climate records: 1,200 years of peak cherry blossom dates in Kyoto. The researcher who maintained it, Prof. Yasuyuki Aono, sadly passed away last year.
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Savage Lab @savagecatsonly.bsky.social · 31/03/2026
Can CRISPR edits enable precise tuning of plant gene expression? We think: yes. In our newest manuscript, we measured the effects of >30,000 CRISPR-like promoter mutations in sorghum protoplasts.
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Kevin Mitchell @wiringthebrain.bsky.social · 01/04/2026
Unstructured transcription factor interactions enable emergent specificity www.science.org/doi/10.1126/... - such an interesting paper!
science.org
Unstructured transcription factor interactions enable emergent specificity
How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), ...
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Nature Ecology & Evolution @natecoevo.nature.com · 30/03/2026
Chromatin plays a central role in gene regulation, but chromatin systems are only known for a few model species. This study analyses chromatin regulatory landscapes in brown algal lineages to elucidate their structural organization and evolution 🧪 www.nature.com/articles/s41...
nature.com
Evolution of a distinct chromatin regulatory landscape in brown algae - Nature Ecology & Evolution
Chromatin plays a central role in gene regulation, but chromatin systems are only known for a few model species. This study analyses chromatin regulatory landscapes in brown algal lineages to elucidat...
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eLife @elife.bsky.social · 27/03/2026
Nature’s toxic cocktails
buff.ly
Nature’s toxic cocktails
Phytochemical mixtures of related molecules with slightly different structures enhance Milkweeds' defense mechanisms against herbivores.
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Michael Habig @michaelhabig.bsky.social · 25/03/2026
Now out! We show that TEs can be horizontally transferred between fungal species via Starships. Once transferred, these TEs can become active, changing the genome organization and affecting the lifestyle of the recipient fungus. www.nature.com/articles/s41... @oggenfussursula.bsky.social #TEsky
nature.com
Transposable elements hitchhike on Starships across fungal genomes - Nature Communications
Large mobile genetic elements known as Starships act as vehicles for transferring transposable elements (TEs) between fungi. Here, Griem-Krey et al. show that these ‘hitchhiking’ TEs can drive rapid e...
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