The authors deplete the cohesin activator NIPBL during the mitosis-to-G1-phase transition. They observe that structural loop formation is impaired proportionally to loop length, while gene activation ...

Summary: This Review discusses recent insights into the factors controlling enhancer specificity and how this might help us understand the genetic basis of human disease.

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery

The Berlin Organoid Symposium will highlight recent advances in the field, covering topics from fundamental organoid biology to translational applications. By uniting scientists from various instituti...

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Correct patterning of emerging tissues in the developing embryo is essential for the formation of functional organ systems. Using genetic tools for controlled protein depletion, Ee et al. identify the...

Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

The REX element is associated with long-range enhancer–promoter interactions.

Join our guest speaker, Dr. Alvaro Rada-Iglesias, in this exciting seminar on the 3D Regulatory Genome, sponsored by Enhanced Genomics.

Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.