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Rui Guan

@guan06rui.bsky.social
198 followers 134 following 2 posts

Computational microbiologist

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Reposted by Rui Guan
Pepe Flores @ppflrs.bsky.social · 11/09/2026
You'll never dry alone: cross‐kingdom metabolic coupling supports the desiccation resilience in a macroalgal holobiont - nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com
You'll never dry alone: cross‐kingdom metabolic coupling supports the desiccation resilience in a macroalgal holobiont
Click on the article title to read more.
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Reposted by Rui Guan
Paloma Durán @paduba.bsky.social · 14/09/2026
Happy to share our latest work digging a bit more into what makes the the core microbiota of photosynthetic organisms convergent (or not!). Work performed @lipme-toulouse.bsky.social @cnrs.fr, in collaboration with @guan06rui.bsky.social @quadraminstitute.bsky.social tinyurl.com/3e958dt6 (1/10)
tinyurl.com
Environmental factors and microbe-microbe interactions drive the structure of the core microbiota of terrestrial microalgae
Plants and other photosynthetic organisms interact with their environment and surrounding microbiota through specialized associations. A global core microbiota has been proposed at high taxonomic levels, such as the order level. However, it remains unclear which environmental factors and how microbe-microbe interactions drive variation of this core microbiota at lower taxonomic resolution. Here, we leveraged the environmental diversity of 141 sites across the southwest of France to characterize algal populations, and their associated bacterial and fungal microbiota. We then performed a meta-analysis, combining these data with published datasets to formally identify the global core microbiota of terrestrial photosynthetic organisms, which comprises seven bacterial and five fungal orders. We next investigated diversity within this core microbiota and the environmental drivers shaping site-specific community composition. While environmental factors have a low impact on the total relative abundance of core orders, the core microbiota at the ASV-level is impacted by climatic factors, edaphic factors, and plant community descriptors. Using interaction network analysis, we finally explored how microbe-microbe interactions contribute to the assembly of stable core communities. Our results show that core ASVs occupy central positions in algal-associated microbial networks and that distinct core orders drive site-specific variation in core microbiota structure. Together, these findings highlight the importance of both environmental context and microbial interactions in shaping the composition and stability of the core microbiota associated with photosynthetic organisms. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, 951444 – PATHOCOM, erc-stg-948219, EPYC Agence Nationale de la Recherche, ANR-10-LABX-41 Biotechnology and Biological Sciences Research Council, https://ror.org/00cwqg982, BB/ X011054/1, BBS/E/F/000PR13631
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SK Winnicki, PhD 🏳️‍⚧️ @skwinnicki.bsky.social · 02/09/2026
Honors roll student who applied for legal admission through the now-defunct CBP app. Lost his college sports scholarship when the feds revoked TPS for all Haitian refugees. Wanted to be a doctor. They're killing our kids, our neighbors www.nbcnews.com/news/us-news...
nbcnews.com
Haitian student dies by suicide after ICE issued him an ankle monitor
Pierre Damas Bel, 20, of Springfield, Ohio, expressed feeling “shame and humiliation” at having to wear an ankle monitor. The college student died by suicide days later.
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Reposted by Rui Guan
Nature @nature.com · 15/07/2026
A ketogenic diet promotes tumour growth in the small intestine in susceptible mice go.nature.com/3TB3Cge
go.nature.com
A high-fat, low-carbohydrate diet can feed intestinal tumours
A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.
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Reposted by Rui Guan
BWJones @bwjones.bsky.social · 05/06/2026
Doing a linear stretch on these images shows how dramatic the "edits" were, revealing the deception in clear terms. This should be a complete scandal for Thermo Fisher and more people in the biosciences should be talking about it.
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Nature Reviews Genetics @natrevgenet.nature.com · 28/03/2025
Transcriptomics in the era of long-read sequencing go.nature.com/421ZTJm #Review by @carolinamonzo.bsky.social, Tianyuan Liu & @anaconesa.bsky.social @conesalab.bsky.social @i2sysbio.bsky.social
go.nature.com
Transcriptomics in the era of long-read sequencing - Nature Reviews Genetics
Advances in long-read sequencing are driving the implementation of these technologies for transcriptome profiling. The authors provide a comprehensive guide to long-read RNA sequencing, including expe...
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Reposted by Rui Guan
Nature @nature.com · 17/04/2026
🔊 This week, the team discuss penguins picking up PFAS pollution go.nature.com/4sG9rVI
go.nature.com
Briefing Chat: Penguins pick up PFAS pollution
Hear the biggest stories from the world of science | 17 April 2026
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Reposted by Rui Guan
Quadram Institute @quadraminstitute.bsky.social · 14/04/2026
🆕 Vacancy! We’re looking for a Research Scientist (Data Science) to join Professor @bioinf.bsky.social 's group to investigate how novel fermented plant-based foods influence the human gut microbiome 📊 💷 £37,500 to £43,350 🗓️ Apply by 17 May 2026 ➡️ buff.ly/X88I01N
A social media card with a photo of fermented food and the text "Research Scientist (Data Science) to investigate how novel fermented plant-based foods influence the human gut microbiome, Salary: £37.500 to £43,350, Contract length: 2 years, Apply by 17 May 2026"
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Ákos T Kovács @evolvedbiofilm.bsky.social · 09/04/2026
Kathrin Wippel (UvA): Bacterial interactions influencing microbiome composition and plant performance #NIME2026
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Naomi Iris van den Berg @naomiirisvdberg.bsky.social · 27/11/2025
More immune cells should mean better outcomes. Yet in kidney cancer, glioma, uveal melanoma - it doesn’t. We think tissue metabolism is the missing variable. Immunometabolic gatekeeping - preprint out now 🔗 arxiv.org/abs/2511.20883
Conceptual diagram summarising the immunometabolic gatekeeping hypothesis in conjunction with canonical understanding of the link between high metabolism and cancer.
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Reposted by Rui Guan
Quadram Institute @quadraminstitute.bsky.social · 26/11/2025
"These findings reinforce the urgent need to understand how drugs and other xenobiotics affect the gut microbiome." 💬 Our Director, Professor @dfigeys.bsky.social
buff.ly
Prebiotics reverse effects of anti-depressants on the gut microbiome - Quadram Institute
Scientists from the University of Ottawa and Beijing Institute of Lifeomics found that SSRIs, SNRIs and Tricyclic Antidepressants, commonly prescribed anti-depressants that target the…
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Reposted by Rui Guan
starchlab.bsky.social @starchlab.bsky.social · 06/11/2025
An exciting opportunity to join my group @quadraminstitute.bsky.social to contribute to the development of our work on #microbiome#food interactions using cutting edge anaerobic fermentation models
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Reposted by Rui Guan
Quadram Institute @quadraminstitute.bsky.social · 04/11/2025
🎓 #PhDPosition ! 🍔 Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome with Dr Falk Hildebrand @bioinf.bsky.social 📅Apply by 2 December ➡️ buff.ly/Pf6wmqO
A digital illustration of the gut microbiome with the text "Funded PhD, Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome, with Dr Falk Hildebrand, Apply by 2 December 2025"
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Nature Reviews Genetics @natrevgenet.nature.com · 30/10/2025
New online! From clonality to complexity: a journey through microbial ecology and evolution
nature.com
From clonality to complexity: a journey through microbial ecology and evolution
Nature Reviews Genetics, Published online: 30 October 2025; doi:10.1038/s41576-025-00910-6Jaime Martinez-Urtaza reflects on two papers by Smith et al., who found that bacteria exist along a continuum from clonal to recombining populations, and introduced the concept of an ‘epidemic’ microbial population structure.
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Quadram Institute @quadraminstitute.bsky.social · 27/10/2025
🆕We’re looking for a motivated candidate to explore the evolution of the gut microbiome in patients with Inflammatory Bowel Disease, working on cutting-edge metagenomics with clinical translation 🧬 🗓️ Apply by 6 January 2026 ➡️ buff.ly/dFWnLv7 @bioinf.bsky.social
PhD position advertisement that reads "Funded PhD. Exploring the genetics of gut microbiomes spatially resolved in IBD patients. With Professor Falk Hildebrand. Apply by 6 January 2026."
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Reposted by Rui Guan
UK GIBA Network+ @ukgibanetwork.bsky.social · 06/10/2025
There was great energy in #Southampton for our recent launch event 🌟 Want to catch up on the highlights from an exciting day? Check out our new event report 👇 www.giba-uk.org/highlights
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Reposted by Rui Guan
AI in the Biosciences (AIBIO UK) BBSRC Network @aibio-uk.bsky.social · 08/10/2025
🚀 AIBIO-UK x L2D Training Scholarships 25 fully funded spots for biosciences researchers to learn: 🔹 Python 🔹 Data handling 🔹 ML & AI 🗓️ Apply by 21 Oct: forms.office.com/e/rVf0Q2H9a5 🔗 Info: aibio.ac.uk/opportunitie... #AIBIOUK #AIinBiosciences #L2D #Scholarships
forms.office.com
Microsoft Forms
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Paloma Durán @paduba.bsky.social · 03/10/2025
TIRIS Postdoc fellowship call will soon be open in Toulouse! If you're interested in plant microbiota, or plant-plant interactions or experimental evolution, the ECOGEN team at the @lipme-toulouse.bsky.social would be happy to support and help with your application!
tiris.univ-toulouse.fr
AToUT – TIRIS – Toulouse's Science In and For Society
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UK Research and Innovation @ukri.org · 23/09/2025
Exciting to see this launch today! This research is an excellent example of using plant science to improve human health, and highlights the value of BBSRC’s long-term investment in plant and nutritional science🍅🔬
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Hall Lab @halllab.bsky.social · 11/09/2025
Excited to share our @cp-cellhostmicrobe.bsky.social led by Magda showing how Bif has co-evolved with different animal hosts 🐒🐭🐷🐦 Key takeaways: 🔹 Host ancestry + diet shape Bif evolution 🔹 Mammals enriched for carb-busting enzymes 🔹 Untapped diversity in non-human hosts = new probiotic potential
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Alexandre Almeida @alexmsalmeida.bsky.social · 10/09/2025
🚨 New pre-print from the lab! We performed a large-scale meta-analysis of the uncultured gut #microbiome in >10,000 metagenomes enabling us to identify a new candidate biomarker of health. www.biorxiv.org/content/10.1...
biorxiv.org
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a new candidate biomarker of health
The human gut microbiome plays an important biological role in host health, yet over 60% of gut species remain uncultured and hence inaccessible to experimental manipulation. Here we analysed 11,115 h...
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Reposted by Rui Guan
Quadram Institute @quadraminstitute.bsky.social · 03/09/2025
🆕 Vacancy! We’re looking for a #Metagenomics Research Scientist to join the Laboratory of Dr Falk Hildebrand @bioinf.bsky.social to study diet impact on the gastrointestinal microbiome. 💷 £37,500 - £42,000 🗓️ Apply by 30 September 2025 ➡️ buff.ly/uwqGQQm
An illustration of a network with the text "Metagenomics Research Scientist, to join Falk Hildebrand's group to study the diet impact on the gastrointestinal microbiome. Salary: £37,500 to £42,000, Contract length: 2.5 years, Apply by 30 September 2025"
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Quadram Institute @quadraminstitute.bsky.social · 22/08/2025
🆕 Blog! PhD student Glória Máté-Koncz explains the science of how we digest beans and how we study the digestion process here at the Quadram Institute 🫘 buff.ly/xuq1lcB
quadram.ac.uk
How do we digest beans? - Quadram Institute
PhD candidate Glória Máté-Koncz explains the science of how we digest beans and how we study the digestion process here at the Quadram Institute.
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Centre for Microbial Interactions @norwichmicro.bsky.social · 14/08/2025
Check out this week's blog from Dr Emily Jones at the @quadraminstitute.bsky.social to hear about her trip to Brussels for the Microphysiological Systems World Summit 2025. Great to see microbiology research in Norwich being shared with international audiences! www.cmi-norwich.ac.uk/presenting-n...
cmi-norwich.ac.uk
Presenting new research at an international conference: using microphysiological systems (MPS) to study microbial infections
Dr Emily Jones visits Brussels to share her latest findings and network with researchers from around the world.
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Fantin Mesny @mesny.bsky.social · 15/08/2025
📣 NEW PREPRINT 📝 We identified evolutionary origins of many fungal effectors! We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression. www.biorxiv.org/content/10.1... cc @teamthomma.bsky.social
biorxiv.org
Plant-associated fungi co-opt ancient antimicrobials for host manipulation
Evolutionary histories of effector proteins secreted by fungal pathogens to mediate plant colonization remain largely elusive. While most functionally characterized effectors modulate plant immunity, ...
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Nick Desnoyer @nickdesnoyer.bsky.social · 11/08/2025
To promote the collection, I’ve launched a designer clothing line where synthetic biology meets aesthetics. I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com 🧵(6/7)
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Nick Desnoyer @nickdesnoyer.bsky.social · 11/08/2025
Introducing the 1,000 Flower Collection 🧬🌹 I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes. Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
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Asaf Levy @asaflevylab.bsky.social · 21/07/2025
📢 New preprint alert! We used comparative genomics on 72,000+ bacterial genomes to uncover the genetic basis of microbial adaptation to multicellular hosts—plants and animals alike. www.biorxiv.org/content/10.1...
biorxiv.org
The Genetic Basis of Bacterial Adaptation to Hosts
Microbes colonize and interact with diverse multicellular hosts using specialized genes, many of which remain unidentified. Better understanding of host-associated gene functions is a key aspect of mi...
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kathywippel.bsky.social @kathywippel.bsky.social · 16/07/2025
Our paper on Pseudomonas intra-genus competition in SynComs on Arabidopsis roots is now out @plosbiology.org ! 🎉 If you want to chat about the story, visit poster 374 tomorrow, Thursday #2025ISMPMI journals.plos.org/plosbiology/...
journals.plos.org
Pseudomonas intra-genus competition determines the protective function of synthetic bacterial communities in Arabidopsis thaliana
The plant microbiome can protect its host against detrimental bacterial strains. This study shows that competition among Pseudomonas bacteria in synthetic bacterial communities determines how well the...
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Quadram Institute @quadraminstitute.bsky.social · 13/07/2025
Our researchers are running a study to assess different ways of helping vegans increase their daily intake of essential nutrients 🌿 ✅ If you’d like to help us, register to take part 📣 Please RT and share! ➡️ buff.ly/4c2yGsP
A photo looking down a bowl full of cous-cous, kale, olives and almonds. Around the edge of the bowl is kale and utensils, on a blue table.
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The Guardian @theguardian.com · 13/07/2025
Some gut microbes can absorb and help expel ‘forever chemicals’ from the body, research shows
theguardian.com
Some gut microbes can absorb and help expel ‘forever chemicals’ from the body, research shows
Previously, the only way to reduce levels of Pfas was by bloodletting or a drug with unpleasant side effects * Sign up for the Detox Your Kitchen newsletter Certain kinds of gut microbes absorb toxic Pfas “forever chemicals” and help expel them from the body via feces, new first-of-its-kind University of Cambridge research shows. The findings are welcome news as the only options that exist for reducing the level of dangerous Pfas compounds from the body are bloodletting and a cholesterol drug that induces unpleasant side effects. Continue reading...
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Kiran R. Patil @kiranrpatil.bsky.social · 02/07/2025
Excited to share some key details on our latest research in @natmicrobiol.nature.com reporting intra-cellular accumulation of #PFAS (aka forever chemicals) by certain human gut bacteria. #microsky #mevosky #microbiomesky www.nature.com/articles/s41...
Human gut bacteria bioaccumulate PFAS
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Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · 01/07/2025
Gut bacteria to the rescue! 🦠✨ They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social) uncovers how. We’re proud to have contributed to this exciting work! #Microbiome #Detox www.nature.com/articles/s41...
nature.com
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...
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Savitski Lab @savitski-lab.bsky.social · 01/07/2025
Beautiful work from my friend @kiranrpatil.bsky.social . Gut bacteria can accumulate Forever chemicals and help us get rid of them! Happy we could contribute! www.nature.com/articles/s41...
nature.com
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...
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FutureFactual @futurefactual.bsky.social · 01/07/2025
🔍 Read: Within minutes of exposure, these bacterial species tested soaked up between 25% and 74% of the introduced PFAS. phys.org/news/2025-06...
phys.org
Certain species of microbe found in the human gut can absorb PFAS
PFAS have been linked with a range of health issues including decreased fertility, developmental delays in children, and a higher risk of certain cancers and cardiovascular diseases.
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Science Blog @scienceblog.com · 01/07/2025
Gut Bacteria Can Protect Against Forever Chemicals Scientists have discovered that certain microbes living in our intestines can absorb toxic "forever chemicals" called PFAS, potentially offering a natural defense against these widespread pollutants. Researchers at the University of Cambridge…
scienceblog.com
Gut Bacteria Can Protect Against Forever Chemicals
Scientists have discovered that certain microbes living in our intestines can absorb toxic "forever chemicals" called PFAS, potentially offering a natural defense against these widespread pollutants. Researchers at the University of Cambridge found that specific gut bacteria can soak up between 25% and 74% of PFAS within minutes, storing the chemicals in dense clusters inside their cells while continuing to grow normally.
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Kiran R. Patil @kiranrpatil.bsky.social · 30/06/2025
Latest study from the lab is online today (and another will be out tomorrow, stay tuned:)). We profiled effect of >1700 chemicals (drugs, pesticides,...) on secretion of amines (involved in gut-brain and gut-immune axis. ) by human gut bacteria. Brilliant work by @skamrad.bsky.social and Tara Davis
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Cambridgeshire @cambridgeshireuk.bsky.social · 01/07/2025
Scientists discover protection from PFAS chemicals #Cambridgeshire #BBCNews 🔗: www.bbc.com/news/arti...
bbc.com
Scientists' discovery could help protect against PFAS chemicals
Cambridge University scientists say a certain species of microbe in the human gut can absorb PFAS.
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UK Research and Innovation @ukri.org · 01/07/2025
A new study has found that toxic PFAS could be absorbed by a gut microbe, potentially protecting us from a range of health issues associated with ‘forever chemicals’. www.ukri.org/news/gut-bac... @mrc-tu.bsky.social
ukri.org
Gut bacteria can remove PFAS ‘forever chemicals’ from our body
Study finds that toxic PFAS could be absorbed by a gut microbe, potentially protecting us from a range of health issues associated with ‘forever chemicals’.
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Science X / Phys.org @sciencex.bsky.social · 01/07/2025
Certain gut bacteria can absorb and help remove PFAS chemicals from the body, suggesting a potential role for the microbiome in mitigating PFAS exposure and its associated health risks.
phys.org
Certain species of microbe found in the human gut can absorb PFAS
PFAS have been linked with a range of health issues including decreased fertility, developmental delays in children, and a higher risk of certain cancers and cardiovascular diseases.
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Quadram Institute @quadraminstitute.bsky.social · 20/06/2025
🆕 New UK study highlights how food structure plays a key role in digestion and health 🍽️ buff.ly/lQkUJys
buff.ly
New UK study highlights how food structure plays a key role in digestion and health - Quadram Institute
Research shows that foods made with chickpea flour prepared in a way to keep the plant cells intact trigger a much healthier metabolic response
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Ka Wai Ma @kawaima.bsky.social · 16/05/2025
Friends from the MPMI committee. Your vote matters. The race is really tight, but I will testify based on personal experience that Wenbo is actively contributing to the MPMI committee, an advocate for diversity and a supporter for early career scientists including me. www.ismpmi.org/members/Page...
ismpmi.org
Wenbo Ma
Wenbo MaThe Sainsbury Laboratory, United KingdomView Statement​​IS-MPMI has been a cornerstone of my journey as a scientist and leader, from attending my first Congress in 2005 (Mérida, Mexico), to se...
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George Bouras @gbouras13.bsky.social · 16/05/2025
www.biorxiv.org/content/10.1... Autocycler, the automated successor to Trycycler from @rrwick.bsky.social has a pre-print out - overall, pretty awesome performance (and is very easy to use) github.com/rrwick/Autoc...
biorxiv.org
Autocycler: long-read consensus assembly for bacterial genomes
Motivation: Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-level and structural errors. Consensus assembly using ...
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Ronnie de Jonge @dejongepmi.bsky.social · 15/05/2025
🌱 We're hiring! Join our team as a PhD candidate to explore plant–microbiota host specificity. Plant biology/microbiology background needed; bioinformatics skills a big plus💻! Apply by mid-June. www.uu.nl/en/organisat... #uubeta #plantmicrobiome #microbiota
uu.nl
PhD Position on Decoding Plant Microbiota–Host Specificity Using AI
Join us to generate data and build AI-driven models to decode plant–microbiota host specificity!
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Alvaro San Millan @sanmillan.bsky.social · 15/05/2025
New opinion paper from the lab! www.cell.com/trends/micro...
cell.com
Plasmid–bacteria associations in the clinical context
Antimicrobial resistance (AMR) is one of the most pressing global health problems, with plasmids playing a central role in its evolution and dissemination. Over the past decades, many studies have inv...
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Engineering Biology Interdisciplinary Research Centre @engbioirc.bsky.social · 15/05/2025
Join us at CafeSynthetique on 2 June with talks from Wes Roberston @mrclmb.bsky.social 'Synthetic genomics for microbiome reprogramming' and SonjaBlasche @sonjablasche.bsky.social @mrc-tu.bsky.social 'milk kefir🥛 in fermented food applications' Register here 🦠👉 www.tickettailor.com/events/engin...
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Rui Guan @guan06rui.bsky.social · 15/05/2025
Wonder the "chemicals" between gut bug pairs? Check out this new preprint lead by @skamrad.bsky.social and am honored to contribute!
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Mario dos Reis @mariodosreis.bsky.social · 06/05/2025
Frustrated that MCMCtree does not have complex substitution models? The IQ-tree team has now developed IQ2MC, an interface for seamless integration of IQ-tree's substitution models with MCMCtree's fast Bayesian pipeline for clock dating. Read the preprint here: ecoevorxiv.org/repository/v...
ecoevorxiv.org
IQ2MC: A New Framework to Infer Phylogenetic Time Trees Using IQ-TREE 3 and MCMCTree with Mixture Models
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Josie Bryant @josiebryant.bsky.social · 01/05/2025
Happy to share the first preprint from my lab. Great work by Lewis Fisher and collaboration with Jukka Corander www.biorxiv.org/content/10.1...
biorxiv.org
High frequency body site translocation of nosocomial Pseudomonas aeruginosa
Pseudomonas aeruginosa is an important nosocomial pathogen which can cause serious infections across diverse anatomic locations. Infections can spread within an individual to different body sites, but...
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Pedro Beltrao @pedrobeltrao.bsky.social · 01/05/2025
The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics. gimm.pt/jobs/open-ca...
gimm.pt
Research Group Leaders – GIMMResearch Group Leaders – GIMM
Thank you very much for your generous donation and for sharing your testimony.We hope to more people feel inspired to join this mission of discovery and innovation!
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