With funding from the German Research Foundation’s (DFG) Heisenberg Program, DKFZ researcher Aurélie Ernst aims to investigate how massive changes in the genome contribute to the development of cancer...

Three researchers at the German Cancer Research Center (DKFZ) have each been awarded a Starting Grant from the European Research Council (ERC) this year. Daniel Kirschenbaum, Lena Kutscher, and Michae...

Three researchers at the German Cancer Research Center (DKFZ) have each been awarded a Starting Grant from the European Research Council (ERC) this year. Daniel Kirschenbaum, Lena Kutscher, and Michael Scherer impressed the ERC with their innovative research approaches to fundamental questions in cancer medicine. With the funding, they plan to investigate why certain brain tumors occur more frequently in boys than in girls, how brain tumors suppress the immune system, and which epigenetic characteristics make cancer cells resistant to drugs.

Metastatic dissemination represents the major determinant of poor clinical outcome across cancer entities. Yet, how driver oncogenes shape transcriptional programs facilitating metastasis is poorly un...

Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...

Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Der erste Einsatz einer speziellen Immuntherapie bei einem Teenager zeigt das Potenzial gentechnisch veränderter patienteneigener T‑Zellen. Noch ist es ein individueller Heilversuch, doch er gibt Hoff...

In a child with advanced nephroblastoma, T-cell therapy targeting preferentially expressed antigen in melanoma led to a 69% tumor reduction, with molecular, metabolic, and histologic evidence of co...

DNA double-strand breaks (DSBs) activate repair pathways that must be coordinated with other cellular functions. Although DSB sensors SIRT6, Ku80, and MRE11 initiate repair, how they organize these nu...

Central conclusions rarely change when biomedical preprints go on to be published in journals.

Job Title: Associate or Senior Editor, Nature Genetics Location: Shanghai, Beijing, Madrid, Milan or Pune, Hybrid Working Model Application Deadline: Aug 3rd, 2026 About Springer Nature Springer Natur...

Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...

Mit seinen „Proof of Concept“ (PoC)-Grants unterstützt der Europäische Forschungsrat (ERC) Wissenschaftler dabei, das wirtschaftliche Potential ihrer Forschungsergebnisse weiterzuentwickeln. Auch 2026...

Nature Communications - The regulatory roles of oncogenic KRAS in cell death pathways remain poorly understood. Here the authors report that KRAS induces a type I interferon response that primes...

Ewing sarcoma (EwS) is an aggressive malignancy driven by EWSR1::ETS fusions, predominantly EWSR1::FLI1. Previous efforts using both direct and indirect approaches to target these chimeric oncoprotein...

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is often associated with dismal outcomes, underscoring the urgent need for new therapeutic strategies. RMS arises from emb...

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.