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Gabriele Pollara

@gpollara.bsky.social
9.5K followers 1.7K following 5.6K posts

Infectious Diseases doctor (at UCLH) and academic (at UCL). Research focuses on host-pathogen interactions in TB, leprosy and UTIs. What are the immune, epithelial and stromal cell responses involved, and could they be targets for host-directed therapies?

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Gabriele Pollara @gpollara.bsky.social · 05/10/2026
An RCT in treatment of leprosy type 2 reactions / erythema nodosum leprosum (ENL). Tough trial to do, especially in middle of COVID. Underpowered but no clear benefit of methotrexate over prednisolone. Can do better than pred hopefully #IDSky #leprosy journals.plos.org/plosntds/art...
journals.plos.org
Methotrexate and Prednisolone compared to placebo and prednisolone in the treatment of severe Erythema Nodosum Leprosum: An international multicentre, double-blind randomised controlled clinical trial...
Author summary Why was this study done? Erythema nodosum leprosum (ENL) is a painful, relapsing inflammatory complication of leprosy that often requires prolonged courses of oral corticosteroids. ...
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Reposted by Gabriele Pollara
Prof Jenny Rohn @jennyrohn.bsky.social · 02/10/2026
Closes tonight at 23:59! Last chance to apply for this #job with @gpollara.bsky.social and me! 👇 #UTISky #MicroSky
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Prof Jenny Rohn @jennyrohn.bsky.social · 21/09/2026
Please do consider applying for this exciting lab role with @gpollara.bsky.social and me - nice blend of advanced culture models, immunology, microbiology and ‘omics, in our friendly Central London labs. Closes 2 Oct, please amplify! Happy to chat informally #UTI #UTISky
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Gabriele Pollara @gpollara.bsky.social · 21/09/2026
🚨 NEW RESEARCH TECHNICIAN POST 🚨 👉 Interested in understanding the biology of recurrent UTI? 👉 Keen to work in my own and @jennyrohn.bsky.social research groups at UCL? Then please do take a look at new position available 👇. Informal enquiries encouraged. #UTISky www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Gabriele Pollara @gpollara.bsky.social · 21/09/2026
yes, that is true as well, agree.
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Gabriele Pollara @gpollara.bsky.social · 21/09/2026
More diagnostic tests don't always = better or reduced antibiotic prescribing. Well, not CRP in primary care anyway! #IDSky #ClinMicro @jac-amr.bsky.social academic.oup.com/jacamr/artic...
academic.oup.com
Is C-reactive protein the answer to antibiotics over-prescribing in primary care? A behavioural experiment in two European countries
AbstractBackground. Antibiotic overprescribing fuels antimicrobial resistance. C-reactive protein (CRP) is widely promoted as a point-of-care test for targ
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Gabriele Pollara @gpollara.bsky.social · 17/09/2026
Agree game changing! Notable to me that unlike OVIVA, this will really need to be a partnership change of doing things with orthopaedic teams - surgery itself will need local antibiotic delivery devices planned etc... Not a bad thing at all, it's not an ID-only stewardship change of practice #IDSky
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Ilan Schwartz @germhuntermd.bsky.social · 17/09/2026
Less is more, ortho-ID edition Another game changer in ortho ID from the group that brought you OVIVA Pts with ortho infections who underwent curative surgery (no DAIR) with local implantation of abx were randomized to <=7d vs >=4w ABx No Dif in 12 mo relapse www.nejm.org/doi/full/10.... #IDSky
Forest plot with primary analysis results which shows no difference in definite treatment failure, definite/probable treatment failure, or definite/probable/possible treatment failure according to treatment durationForest plot showing subgroup analysis which shows no difference between shorter and longer duration antibiotics in any of the subgroups including prosthetic infection, Staph aureus mono infection, and whether local gentamicin was used in mono therapy or combination therapy
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Gabriele Pollara @gpollara.bsky.social · 17/09/2026
Masterful drive and use of DRS!
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Gabriele Pollara @gpollara.bsky.social · 15/09/2026
Is the destination photo as critical?! 😉
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Gabriele Pollara @gpollara.bsky.social · 15/09/2026
Obligatory "en route" photo to EMBO "the complexity of mycobacterial infections" meeting in Paris. Looking forward to presenting some of our work on leprosy reaction immunopathogenesis. #embocomplexinfections @embo.org #TBSky #leprosy
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Gabriele Pollara @gpollara.bsky.social · 15/09/2026
excellent coverage. enjoy the off season, though sure you'll be doing other commentary!
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Gabriele Pollara @gpollara.bsky.social · 15/09/2026
excellent summary that!
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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026
Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n
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Joseph Marcus @josephmarcusid.medsky.social · 10/09/2026
Antimicrobial use in ECMO is poorly described. We evaluated AU at our center and found, despite no ECMO specific ppx protocol, antimicrobials were prescribed on 85% of pt days😱 doi.org/10.1017/ash.... Also my teams first use of a bubble plot 🫧 #ECMO #IDSky @ashejournal.bsky.social
doi.org
Antimicrobial use in adult patients receiving extracorporeal membrane oxygenation in a center without routine prophylaxis | Antimicrobial Stewardship &amp; Healthcare Epidemiology | Cambridge Core
Antimicrobial use in adult patients receiving extracorporeal membrane oxygenation in a center without routine prophylaxis - Volume 6 Issue 1
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Gabriele Pollara @gpollara.bsky.social · 10/09/2026
that may be true, but it would be a consultation with a very clear end goal of getting a MRI. Hard to steer a patient away from that if that was their entry into the appointment.
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Gabriele Pollara @gpollara.bsky.social · 10/09/2026
Terrible advert on London Underground. How about booking an appointment to speak to a human doctor to discuss medical concerns?
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
You may be better off just having a separate browser tab. We can definitely make a journal club hashtag-led feed @skyfeed.app or @skyfeed.eu , super easy, but it's not perfect at pulling in all posts and there's definitely a bit of a delay.
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
TBH i don't think we need to - if there is hashtag discipline, which there should be, then easiest thing is just to click on the hashtag. Much simpler than making a feed?
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
nice work Chris!
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Chris Hopkins @chrishopkins123.bsky.social · 08/09/2026
Really happy to finally get this published! This is a qualitative study on front-line clinicians' rationale for sending urine cultures. The 4 themes we identified are summarised in the diagram. #UTIsky www.cambridge.org/core/journal...
cambridge.org
Changing the culture: a qualitative study on clinicians’ rationale for requesting urine cultures | Antimicrobial Stewardship &amp; Healthcare Epidemiology | Cambridge Core
Changing the culture: a qualitative study on clinicians’ rationale for requesting urine cultures - Volume 6 Issue 1
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
Late to this, but great news!! Have always found manual thread numbering a tricky art to master 4/2 <END>
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
Hi Angela - that's great news. Will definitely try to tune into that. Last few months I'd reached the "too busy even for social media stage" but now regaining a sense of balance. Have missed this place!
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
Ah yes, thank you @drmichaelmarks.bsky.social - had totally forgotten re primary care part of the study! 🤦‍♂️ That will be really informative because going so short with treatment. I can't remember agents permitted for the UTI part of study do you? (pyelo was B-lactams, but I think not for UTI).
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
Feels a pretty non-controversial title! 😅 (and maybe true for any specialty /profession?!) #AcademicSky #MedSky www.thelancet.com/journals/lan...
thelancet.com
High-quality mentorship can improve physician-scientist recruitment, retention, and career satisfaction
Physician-scientists, who engage in both patient care and scientific inquiry, represent an increasingly small portion of the physician workforce. In the USA, only 1·3% of physicians reported research ...
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
DURATION study analysis likely out this year for pyelonephritis. For UTI, SCOUT phase IV study had a hint of that - 1 dose fosfo less good than 2 doses. Changed my practice! www.sciencedirect.com/science/arti...
sciencedirect.com
Clinical and bacteriological effectiveness of three different short-course antibiotic regimens and single-dose fosfomycin for uncomplicated lower urinary tract infections in women (SCOUT): a pragmatic, multicentre, open-label, randomised clinical trial
Most guidelines recommend nitrofurantoin, fosfomycin, and sometimes pivmecillinam for uncomplicated urinary tract infections (UTIs), but direct compar…
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Gabriele Pollara @gpollara.bsky.social · 09/09/2026
I tend to agree, as relapse feels like the primary concern of any treatment shortening infection study. Though they may argue that Abx free days for treatment of endocarditis (primary outcome) is addressing the same thing in a more quantitative way vs the binary relapse metric?
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Gabriele Pollara @gpollara.bsky.social · 07/09/2026
"Infection-embedded (penicillin allergy) de-labelling is a high-yield intervention that can deliver immediate stewardship returns in patients with active infection needs" #IDSky #ClinMicro @jac-amr.bsky.social academic.oup.com/jacamr/artic...
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Gabriele Pollara @gpollara.bsky.social · 07/09/2026
This says it all. It's not that Palou is not beatable, but no one is able to sustain performance over a season as much as him. And so in the end, his high level coupled with versatility and low error rate, becomes unbeatable. Hard to see it changing until new car in 2028 poses new challenges.
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Gabriele Pollara @gpollara.bsky.social · 06/09/2026
When I have a spare moment (badaboom! 😅) going to need to read this carefully. On face of it illustrates trade offs at the edge of minimal Abx treatment durations. What worse outcomes is one willing to accept in return for shorter treatment duration? #IDSky #MedSky www.nejm.org/doi/full/10....
nejm.org
Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis | NEJM
In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clin...
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Gabriele Pollara @gpollara.bsky.social · 06/09/2026
Kudos to the title of this paper: From bedside to broadband.... 👏 #IDSky
academic.oup.com
From bedside to broadband: Evaluating outcomes of telehealth infectious diseases consultations
Following replacement of in-person with telehealth infectious diseases consultation at a community hospital, mortality, readmission, length of stay and tra
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Gabriele Pollara @gpollara.bsky.social · 06/09/2026
blink and you miss it. Let's hope for a cracking finale!
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Gabriele Pollara @gpollara.bsky.social · 05/09/2026
And even if true, doesn't say much for the attention to detail of a wannabe PM!
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Ramon Garcia Maset @microberamon.bsky.social · 04/09/2026
Excited to share our new paper in Nature Communications! 🎉 Using advanced human bladder models, we explored how the urinary microenvironment and fluid flow shape UPEC pathogenesis and treatment responses. The big message: the environment matters (1/6) 🔗 www.nature.com/articles/s41...
nature.com
Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli - Nature Communications
Maset et al. show that bladder conditions strongly influence how urinary tract infections respond to antibiotics and bacteriophages, highlighting the need for more realistic lab models to improve diag...
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Lepra UK @leprauk.bsky.social · 05/09/2026
Over 100 years ago, Lepra was founded on the premise of evidence-led treatment, community care and compassion - breaking down centuries of stigma. On #InternationalDayofCharity, help us continue to reach those who still desperately need us. ow.ly/Y7VE50ZFvOo 📷 Tom Bradley Photography
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Gabriele Pollara @gpollara.bsky.social · 05/09/2026
UCL looking good (and busy) for its annual Open Day @ucl.ac.uk
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Gabriele Pollara @gpollara.bsky.social · 04/09/2026
Delighted to have contributed (a little) to this - dissecting role of urine, flow and phages on E. coli-urothelial interaction. Most remarkable to me was ability of phages to kill intracellular bacteria AND alter the host inflammatory response. "How" is the next interesting question... 🤔 #UTISky
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
Like this because, aside from any trend of interest, it's based on multiple testing by different pollsters over time. So much more reliable than drawing conclusions from any one snapshot poll.
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
controlled escalation gives hope they know how to controllingly de-escalate... (tho not holding breath on that. Sigh)
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
Sigh. Not good, and longer term implications not really being considered by short term users (myself included, perhaps)
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
Yes sounds like a scam, but you make a good point @lizhighleyman.bsky.social - AI trained on human writing anyway. In the end they will become difficult to reliably distinguish from each other. Heading to an era where only in person spoken word can guarantee human source. 😔 @jennyrohn.bsky.social
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
Horizontal transfer! 😅
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
It's a very good question. Apparently more RCT on their way. If they all point in the same direction, I'd imagine there may need to be a review of the policy. But it's not really my area, TBH.
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
This one has already lasted way too long (to get to the 4 most likely semi finalists anyway!)
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Gabriele Pollara @gpollara.bsky.social · 13/07/2026
That's so sad that these fires were started deliberately (for innocent intentions). Had not heard of these bonfire traditions until now. Feels risky thing to do in dry July summers!
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Gabriele Pollara @gpollara.bsky.social · 11/07/2026
Amazon really needs to up its game - kids are actually still at school!! Can we not even have a gap before thinking about planning the back to school bit?! 🙏
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Gabriele Pollara @gpollara.bsky.social · 09/07/2026
Disappointing data on meningitis vaccine preventing Neisseria gonorrhoea infections Then again negative trial data is as useful as positive findings, so that we focus resources most effectively #IDSky www.nejm.org/doi/full/10....
nejm.org
Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection | NEJM
No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce...
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Gabriele Pollara @gpollara.bsky.social · 09/07/2026
and that's probably quite a high baseline already - could use one including more historical data
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Gabriele Pollara @gpollara.bsky.social · 08/07/2026
I haven't watched a football match for >24 hours now!!!😱 Life feels so empty.... (thankfully will get my fix again from tomorrow! 😅) #FIFAWorldCup
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Ivan Zanoni @lozanzi.bsky.social · 07/07/2026
Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
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