An RCT in treatment of leprosy type 2 reactions / erythema nodosum leprosum (ENL). Tough trial to do, especially in middle of COVID. Underpowered but no clear benefit of methotrexate over prednisolone. Can do better than pred hopefully #IDSky #leprosy
journals.plos.org/plosntds/art...
journals.plos.org
Methotrexate and Prednisolone compared to placebo and prednisolone in the treatment of severe Erythema Nodosum Leprosum: An international multicentre, double-blind randomised controlled clinical trial...
Author summary Why was this study done? Erythema nodosum leprosum (ENL) is a painful, relapsing inflammatory complication of leprosy that often requires prolonged courses of oral corticosteroids. ...