Within the family of Enterobacteriaceae, few species have evolved in parallel with the history of clinical microbiology and infectious diseases as closely as Klebsiella pneumoniae. First described in ...

Once-daily, single-tablet regimens have transformed care for persons living with human immunodeficiency virus type 1 (HIV-1); however, challenges to adherence continue to limit effective treatment....

Yonas Martin, Steven Tong; Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia?, Clinical Infec

Early skip phenomenon in Staphylococcus aureus bacteremia is rare (3.1%) with a very low risk of missed persistent bacteremia (1%). A practical day-2 focus

Switching from intravenous antibiotics to oral fosfomycin was noninferior to continuing intravenous therapy for complicated urinary tract infections caused

FDA approves first oral carbapenem therapy for complicated urinary tract infections

Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...

This cohort study evaluates whether administration of 30 mL/kg or more of fluid within 6 hours of hospital arrival is associated with reduced 30-day mortality in adults with community-onset sepsis.

In this national, multicenter retrospective study of intensive care unit patients with pneumonia in Veterans Health Administration hospitals, BIOFIRE® PN P

Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...

This multicenter prospective study shows that quantitative PCR on oral wash has a better positive predictive value than PCR on bronchoalveolar lavage for t

This international randomized clinical trial evaluates the efficacy of high-dose intravenous vitamin C in reducing 28-day mortality and persistent organ dysfunction (dependence on mechanical ventilati...

This multicentre randomised controlled trial demonstrates that improving oral care reduces NV-HAP incidence among hospitalised patients, compared with usual care. Our findings provide novel and clinic...

Our systematic review with meta-analysis suggests that discontinuation of quinolone prophylaxis during pre-engraftment neutropenia reduces bacterial resist

Abstract. Posaconazole delayed-release (DR) tablets are labelled as ‘do not crush’ medications. Despite this designation, emerging research demonstrates su

Abstract. Companion animals are increasingly recognized as potential reservoirs of antimicrobial-resistant (AMR) bacteria, yet the frequency of sharing bet