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Jitendra Gosai

@gosciee.bsky.social
167 followers 601 following 31 posts

Assistant Research Scientist @ ASU Biodesign Inst, Molecular genetics, Molecular Microbiology, Computational Biology, Host microbe interactions, Biophysics Father, Fixer, Photographer

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Reposted by Jitendra Gosai
Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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Cameron Thrash @jcamthrash.bsky.social · 04/09/2026
Differences in Siderophore Production During the Growth of Phytoplankton in Southern Ocean Incubation Experiments Under High‐ and Low‐Iron Conditions enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs 🌊
enviromicro-journals.onlinelibrary.wiley.com
Differences in Siderophore Production During the Growth of Phytoplankton in Southern Ocean Incubation Experiments Under High‐ and Low‐Iron Conditions
Experiments performed in the Southern Ocean under low- and high-iron conditions showed that the heterotrophic bacteria community produced distinct iron-binding compounds called siderophores, dependin....
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Reposted by Jitendra Gosai
Cameron Thrash @jcamthrash.bsky.social · 03/09/2026
DeepKOALA: a scalable deep learning framework for KEGG Orthology assignment academic.oup.com/bib/article/... #jcampubs
academic.oup.com
DeepKOALA: a scalable deep learning framework for KEGG Orthology assignment
Abstract. The KEGG Orthology (KO) system links DNA and protein sequences to biological functions and pathways, providing a curated, fundamental, and consis
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Jitendra Gosai @gosciee.bsky.social · 04/09/2026
Placement of the results, figures and fig-legends in the manuscripts 50000 miles from one another has to go. It is not 1990s anymore and this is plain dumb. Review this for us but also open in three windows.
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Jitendra Gosai @gosciee.bsky.social · 08/08/2026
Lots of TIL for me but 🤯 Avocado trees alternate their sex daily to ensure outcrossing. this rhythm is driven by the SDMYB transcription factor, a balanced polymorphism maintained by selection for >42 million years.
pnas.org
Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS
In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...
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Jitendra Gosai @gosciee.bsky.social · 29/07/2026
Capitalism can sometimes curb novelty and creativity. Esp. with AI, where the competition is intense, and even with swaths of capex, there is a need to streamline to survive, companies may have to make tough calls. I hope this doesn’t mean a blow to one forefront of science to give way to another.
ft.com
Google DeepMind dismantles Nobel-winning AlphaFold team in strategy shift
Landmark project that solved protein folding gives way to a wider race to build AI systems for scientific discovery
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Jitendra Gosai @gosciee.bsky.social · 25/07/2026
ngl thought this was a rangoli for a min
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Jitendra Gosai @gosciee.bsky.social · 24/07/2026
www.frontiersin.org/news/2026/07... @frontiersin.bsky.social Don’t miss the video. YT top comment summarises better : Orcas prefer scrambled over sunny side up.
frontiersin.org
Orcas filmed ramming one of the world’s heaviest fish so hard it explodes, possibly for fun
Study documenting previously undescribed orca behavior in the Gulf of California finds hold-and-ram strategy could be parental investment – or entertainment
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Jitendra Gosai @gosciee.bsky.social · 17/07/2026
A sentence with AI and employment in it is rarely an uplifting one these days. Here’s the change. America’s Enterprising Spirit Is Booming After Decades-Long Slump www.nytimes.com/2026/07/17/b...
nytimes.com
America’s Enterprising Spirit Is Booming After Decades-Long Slump (Gift Article)
Hundreds of thousands of people are creating companies each year, ending a decades-long drought.
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Jitendra Gosai @gosciee.bsky.social · 10/07/2026
Go in for the bugs, stay for the commentary.
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Reposted by Jitendra Gosai
Kaçar Lab at UW-Madison @kacarlab.bsky.social · 19/06/2026
New preprint! How do you engineer one of biology’s most complex enzymes without breaking it? We used evolution as a guide to map a protein interface in nitrogenase, screening >9,000 variants to reveal sequence-function rules for future nitrogen fixation engineering. www.biorxiv.org/content/10.6...
biorxiv.org
Evolution-guided engineering of an ancient nitrogenase interface enhances enzyme activity and stability
Nitrogenase is the only enzyme capable of biological nitrogen fixation and a major target for sustainable agricultural engineering, yet its functional and structural complexity has made it difficult t...
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Pawel Burkhardt @pawelburkhardt.bsky.social · 16/06/2026
How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...
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Susan Lea @smlea.bsky.social · 16/06/2026
A lot of work, over many years, and we finally see the missing piece at the heart of type 3 export!
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PLOS Biology @plosbiology.org · 05/06/2026
The T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45
Top: Representative confocal fields of the 3 types of TssC-GFP-TssK microcolonies (homogeneous ON, heterogeneous, homogeneous OFF). Scale bars, 10 μm. Bottom:  Model for the role of T6SS phenotypic heterogeneity in EAEC. Top: The Psci1 promoter integrates Fur- and Dam-dependent regulation, generating ON (T6SS⁺, yellow) and OFF (T6SS⁻, blue) subpopulations at a reversible equilibrium. Bottom left: OFF (blue) cells, which do not express T6SS, do not kill competitors but avoid triggering such defences (1). Due to the absence of killing activity, OFF cells are unable to colonize the niche (2). Bottom centre: While ON (yellow) cells assemble and deploy functional T6SS (1) and kill susceptible competitors (2), they provoke retaliatory attacks from defensive T6SS⁺ species (gray) and are eliminated and fail to colonize the niche (3). Bottom right: Heterogeneous ON/OFF population (1) optimizes colonization by killing neighboring cells (2). While ON (yellow) cells are eliminated by counterattacks by defensive T6SS+ species (gray), OFF (blue) cells resist (3) and can ensure a continuous supply of ON cells (4-5) while limiting population-wide exposure to retaliation.
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Abhishek Shrivastava @shrivastavalab.bsky.social · 03/06/2026
If you are at the 2026 ASM Microbe meeting in Washington DC, please check out a talk on sensory origion of zorbs by our lab's postdoc Jitendra Gosai at the 'Holding Tight: the importance of bacterial adhesion' session on June 5th @gosciee.bsky.social
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Jitendra Gosai @gosciee.bsky.social · 04/06/2026
Kickstarting #ASMicrobe in DC this morning. Feels great to be here! 🧵 for all the updates!
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Kumaran Ramamurthi @ramamurthilab.bsky.social · 29/05/2026
Bacterial transmembrane proteins usually localize inside the cell by "finding" a pre-localized protein, but how did the 1st protein get there? @vanipande.bsky.social found a protein in #B.subtilis that localizes by recognizing a *lipid* localization cue. #Microsky www.biorxiv.org/content/10.6...
biorxiv.org
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ISME - International Society for Microbial Ecology @isme-microbes.bsky.social · 26/05/2026
What is the scope of ISME Host Microbe, ISME's newest journal? Effects of antimicrobial agents, human activities, immunity and environment on AND ecological studies, cross-kingdom studies, microbiome studies of host-microbiome/microbe interactions academic.oup.com/ismehm/pages... #MicrobialEcology
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 26/05/2026
Microbial cross-feeding interactions reshape evolutionary trajectories of consumers by preserving motility. www.biorxiv.org/content/10.64898/20…
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Jitendra Gosai @gosciee.bsky.social · 23/05/2026
More scientists as political leaders please!
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Jitendra Gosai @gosciee.bsky.social · 16/05/2026
What a waste of food and perfectly useful furniture.
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Reposted by Jitendra Gosai
Harmit Singh Malik @harmitmalik.bsky.social · 15/05/2026
www.nature.com/naturecareer...
nature.com
Faculty Positions in Advanced Research Unit on Metabolism, Development & Aging at TIFR - Hyderabad, Andhra Pradesh (IN) job with Tata Institute of Fundamental Research Hyderabad | 12858938
Tata Institute of Fundamental Research (TIFR) invites applications for faculty positions in ARUMDA.
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Jitendra Gosai @gosciee.bsky.social · 27/02/2026
I went down the rabbit hole of finding more and found these peckers to be a fascinating species. The most mind-blowing part being:
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Zamin Iqbal @zaminiqbal.bsky.social · 17/02/2026
Delighted to see over 17 million new protein structure predictions from novel proteins in AllTheBacteria are now integrated into the AlphaFold Database at @ebi.embl.org ! Huge work from @gbouras13.bsky.social @oschwengers.bsky.social and friends to generate these. www.ebi.ac.uk/about/news/u...
ebi.ac.uk
AlphaFold Database welcomes community datasets
Latest AlphaFold Database update adds high-value datasets for microbial and viral proteins, generated by specialist communities
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Jitendra Gosai @gosciee.bsky.social · 18/02/2026
Me trying to reach "expansion" from "increase" via inflation, growth, enlargement and swelling. Could i just have asked Gemini or GPT - yes, but, where is the gaudiloquence in that?
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Nature Microbiology @natmicrobiol.nature.com · 22/01/2026
#NatMicroPicks Baby-to-baby strain transmission shapes the developing gut microbiome - out now in Nature! 👶🦠👶 #microsky #microbiome @nature.com @cibiocm.bsky.social www.nature.com/articles/s41...
nature.com
Baby-to-baby strain transmission shapes the developing gut microbiome - Nature
A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infan...
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Nature @nature.com · 21/01/2026
Nature research paper: Construction of complex and diverse DNA sequences using DNA three-way junctions go.nature.com/4qu2ExZ
go.nature.com
Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature
Sidewinder enables high-fidelity DNA assembly by separating the information that guides assembly from the final assembled sequence.
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Sam Hobbs @hobbslabutah.bsky.social · 22/01/2026
Hello world! I am excited to announce my lab is open at the University of Utah in the Department of Biochemistry. We are looking for scientists at all levels interested in studying host-virus interactions in both bacteria and animals. Come join us in beautiful Utah! (photo is 10 steps from lab)
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Guillaume Thibault @gthibault.bsky.social · 17/01/2026
We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297
doi.org
Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.
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Reposted by Jitendra Gosai
Carl T. Bergstrom @carlbergstrom.com · 16/12/2025
I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.
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Jitendra Gosai @gosciee.bsky.social · 17/12/2025
A 16h day in the lab comes to an end. An ambitious experiment, now in incubation, with about 700 ‘spots’ on those plates holding on to the answer of a curious question. With the finals over, the campus is as empty as devoid the air is of winter-y cold. It is somewhat of a good night, I guess.
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AnniZLab: [🦠, 🧬 , ✨] @annizlab.bsky.social · 31/10/2025
A brand-new Gordon Conference on Microbiomes!🦠 The opening session (Jan 2026) dives into microbiome editing - how fundamental research and new technologies can advance human health and environmental sustainability. Super looking forward!🧪 #microsky #microbiomesky #grc www.grc.org/microbiome-e...
grc.org
2026 Microbiome Editing Conference GRC
The 2026 Gordon Research Conference on Microbiome Editing will be held in Pomona, California. Apply today to reserve your spot.
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Jitendra Gosai @gosciee.bsky.social · 29/10/2025
Reviewing an exciting manuscript. This is going to be a long night!
media.tenor.com
a pink cartoon character is surrounded by math equations on a green background
ALT: a pink cartoon character is surrounded by math equations on a green background
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Jitendra Gosai @gosciee.bsky.social · 21/10/2025
www.nature.com/articles/s41...
nature.com
Why editors go to conferences - Nature Microbiology
You may have spotted us at different conferences and wondered what we’re doing amid active researchers. Here, we demystify the editorial aims of conference attendance.
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ISB @isbscience.org · 06/10/2025
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine.... What a tremendous honor! Congratulations!
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Oded Rechavi @odedrechavi.bsky.social · 03/10/2025
Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇
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Ákos T Kovács @evolvedbiofilm.bsky.social · 03/10/2025
Amazing work by @hueihsuantsai.bsky.social and colleagues from @nikogeldner.bsky.social, Feng Zhou @tonnigrubeandersen.bsky.social labs in Science Localized glutamine leakage drives the spatial structure of root microbial colonization www.science.org/doi/10.1126/... #chemotaxis #MicroSky
science.org
Localized glutamine leakage drives the spatial structure of root microbial colonization
Plant roots release exudates to encourage microbiome assembly, which influences the function and stress resilience of plants. How specific exudates drive spatial colonization patterns remains largely ...
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Eric Topol @erictopol.bsky.social · 04/09/2025
Discovery of a new type of immune cell in fat tissue that promotes infllammaging (chronic inflammation with aging) www.nature.com/articles/d41... www.nature.com/articles/s43...
nature.com
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lip...
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EvoCellBio @evocellbio.bsky.social · 29/08/2025
Join us in Arizona! The Fourth Annual Symposium on Mechanisms of Cellular Evolution will again be held at ASU. November 5-8, 2025, in Tempe, AZ. Theme: Unicellular Diversification of Cell Types and Division Systems. na.eventscloud.com/cmesymposium2025
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Nature Microbiology @natmicrobiol.nature.com · 18/08/2025
Out now! 🍫🦠A defined microbial community reproduces attributes of fine flavour #chocolate fermentation By Gabriel Castrillo, David Salt & co #microsky #microbiomesky 🧪 Read it here: www.nature.com/articles/s41...
nature.com
A defined microbial community reproduces attributes of fine flavour chocolate fermentation - Nature Microbiology
An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocol...
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Anne Chevallereau @annechevallereau.bsky.social · 19/08/2025
#phagesky I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ? Repost appreciated :)
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Jitendra Gosai @gosciee.bsky.social · 07/08/2025
On my 14th hour of troubleshooting the code while ChatGPT tells me we are close for the 280th time.
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Stephen Turner @stephenturner.us · 05/06/2025
Site-specific DNA insertion into the human genome with engineered recombinases www.biorxiv.org/content/10.1... in other words... genome engineering to precisely insert large multi-kilobase sequences into specific sites without introducing double-strand breaks #synbio
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Randall Munroe @xkcd.com · 31/05/2025
Internet Roadtrip is my favorite thing on the internet right now—it’s basically Twitch Plays Google Street View. They started in Boston, spent several weeks on a quest to cross the Canadian border, and are now exploring New Brunswick. neal.fun/internet-roa...
neal.fun
Internet Roadtrip
Let's take a streetview roadtrip
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Jitendra Gosai @gosciee.bsky.social · 24/05/2025
Started in Abhishek’s lab as a new postdoc without any coding skills, and now I've contributed to a bacterial-tracking library and debugged critical issues while at that - super happy with this. Thanks to all my more-hardworking-coauthors on this one! Cheers and here is to many more 🥂.
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MwahahahahahadScientist @mads100tist.bsky.social · 20/12/2024
Interviewer: Can you explain this gap in your resume? Me: I was waiting for the Argon laser to warm up
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Wei Shen 沈 伟 @shenwei356.bsky.social · 06/05/2025
TaxonKit v0.20.0 is adapted to recent rank changes in NCBI Taxonomy. github.com/shenwei356/t... Also updated - taxid-changelog to May, 2025 github.com/shenwei356/t... - gtdb-taxdump to GTDB r226 github.com/shenwei356/g... - ictv-taxdump to VMR_MSL40 github.com/shenwei356/i...
github.com
Release TaxonKit v0.20.0 · shenwei356/taxonkit
Changes TaxonKit v0.20.0 This version is mainly for maintaining compatibility with NCBI's recent changes(1, 2). Please remove the ranks.txt file in ~/.taxonkit/ or other directories containing t...
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 04/05/2025
New 𝘕𝘢𝘵𝘶𝘳𝘦 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦 🦠 Personalized Nebulized Bacteriophage Therapy for MDR 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 Infections in Cystic Fibrosis In 9 patients, 10²–10⁴ CFU/mL drop in sputum bacteria, 6% median gain in FEV1 Post-treatment isolates showed trade-offs—reduced virulence, increased antibiotic susceptibility
nature.com
Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis - Nature Medicine
A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of antimicrobial-resistant bacteria...
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Tami Lieberman @contaminatedsci.bsky.social · 01/05/2025
Do people in the same household share strains when they have the same species? How many cells transmit when a strain is shared? Can strain composition be dynamic when species composition is stable? We answer these and related questions for the facial skin microbiome in our latest paper. 🧵[1/10]
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