Nature - Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...

The WRN helicase helps to protect stalled DNA replication forks during replication stress, but its activation mechanism remains unclear. Here, the authors demonstrate that Ku binds and stimulates WRN ...

Tigist Tamir’s journey from aspiring astronaut in Ethiopia to cancer researcher at the University of North Carolina highlights the power of mentorship, persistence and curiosity in shaping a scientifi...

Cell Death & Disease - Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia

The official website of the Sfeir Lab at the Skirball Institute of Biomolecular Medicine of New York University Langone Medical Center.

DNA double strand breaks can be repaired by several pathways leading to different genetic outcomes. Here, the authors define the interplay between the DNA damage response factors 53BP1-RIF1 and core n...

Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…

The annual Genome Stability Symposium provides a forum for trainees in the Southern California region to present their research on the field of genome stability.

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...