Bret Freudenthal @freudlab.bsky.social · 11/08/20261/ Latest publication from the Freudenthal lab in Biomolecules: 8oxoG:A base pairs are structurally accommodated in the nucleosome, yet effectively invisible to MUTYH. doi.org/10.3390/biom... 110
Bret Freudenthal @freudlab.bsky.social · 11/08/20262/ The Delaney lab used globally substituted NCPs covering 34 unique 8oxoG:A positions, MUTYH excised A from essentially every site in duplex DNA but from only two sites in the nucleosome, both at SHL-6.5 in the entry/exit region (thanks David lab as well). 100
