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Fran Rodriguez-Algarra

@franrodalg.bsky.social
692 followers 486 following 40 posts

🖥️🧬 CompBio Postdoc @rakyanlab.bsky.social 📍🏫 Blizard Institute, QMUL 🃏🚧 Jack of all trades, master of none 🐉✍️ fantasist in training orcid.org/0000-0002-4134-2141

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Reposted by Fran Rodriguez-Algarra
QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 30/04/2026
Our Centre for Epigenetics Conference is only a month away! If you haven't booked your tickets yet, you can do so by following this link: eshop.qmul.ac.uk/conferences-...
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Reposted by Fran Rodriguez-Algarra
Mart Krupovic @mkrupovic.bsky.social · 22/04/2026
"The selfish ribosome" paper is now published in @plosbiology.org . Have a look! Many thanks to the editors and reviewers! doi.org/10.1371/jour...
journals.plos.org
The selfish ribosome
In this Essay, the evolution of life is construed as a ribosomal takeover, whereby the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensured the propagatio...
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Reposted by Fran Rodriguez-Algarra
Science Magazine @science.org · 14/04/2026
Variation in the genes coding for RNA strands in ribosomes are associated with human traits, new research suggests. Learn more: scim.ag/4vrvSR4
Differences in cells’ protein factories may help explain human diversity
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Fran Rodriguez-Algarra @franrodalg.bsky.social · 10/04/2026
Great feature piece by @cofford.bsky.social in @science.org about our findings about rDNA sequence variation in the @ukbiobank.ac.uk and its association with body size traits. Don't miss it!!! www.science.org/content/arti...
science.org
Differences in cells’ protein factories may help explain human diversity
Study links mutations in ribosome genes to traits such as height and weight
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Reposted by Fran Rodriguez-Algarra
Dr Radu Zabet @raduzabet.bsky.social · 10/04/2026
My lab and @smarino0111.bsky.social lab are currently looking for 2 PDRAs on a 3-year @bartscharity.bsky.social funded project. The posts will be based in Blizard Institute within Queen Mary Faculty of Medicine and Dentistry. Check out the details and apply here: qmul-jobs.tal.net/vx/mobile-0/...
qmul-jobs.tal.net
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Adam Phillippy @aphillippy.bsky.social · 30/03/2026
More acrocentric investigations, this one led by @arhie.bsky.social 🕵🏻‍♀️ “Biobank-scale genotyping of Robertsonian translocations reveals hidden structural variation on the human acrocentric chromosomes” 🧵[1/8] 📄 www.biorxiv.org/content/10.6...
biorxiv.org
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Fran Rodriguez-Algarra @franrodalg.bsky.social · 10/04/2026
🚨 New Paper Alert!!! We continue exploring rDNA variation in the @ukbiobank.ac.uk and discover that the proportion of rDNA units harbouring specific sequence variants associates with human traits, particularly body size ones! Check it out 👇👇👇
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Reposted by Fran Rodriguez-Algarra
Miguel Branco @brancolab.bsky.social · 02/02/2026
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
biorxiv.org
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Reposted by Fran Rodriguez-Algarra
Trevor Graham @trevorgraham.bsky.social · 16/01/2026
Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...
jobs.icr.ac.uk
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...
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Reposted by Fran Rodriguez-Algarra
Trevor Graham @trevorgraham.bsky.social · 12/01/2026
A big thank you to @bowelcanceruk.bsky.social and all their wonderful supporters for funding our research that aims to develop a blood test to predict bowel #cancer risk for people with inflammatory bowel disease #IBD. www.bowelcanceruk.org.uk/research/our... @icr.ac.uk
bowelcanceruk.org.uk
A new test to predict which people with inflammatory bowel disease will get bowel cancer
Dr Baker and Professor Graham are developing a non-invasive way to predict bowel cancer risk in people who have inflammatory bowel disease.
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Reposted by Fran Rodriguez-Algarra
Adam Phillippy @aphillippy.bsky.social · 24/12/2025
If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!
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Reposted by Fran Rodriguez-Algarra
Robert Seaborne @robertseaborne.bsky.social · 02/12/2025
Final few days to apply for a postdoc pos. in our lab. If you have a passion for large data sets, data integration, sequencing and plenty of problem solving, then this could be for you! Initial 12 months, but with a further 19months available for the right candidate! www.jobs.ac.uk/job/DPK467/p...
jobs.ac.uk
Postdoctoral Research Associate in Computational Muscle Biology at King's College London
Apply for the Postdoctoral Research Associate in Computational Muscle Biology role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
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Reposted by Fran Rodriguez-Algarra
Robert Seaborne @robertseaborne.bsky.social · 12/11/2025
Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work 12 months to begin with, but for the right candidate we have funding for a further 19 months www.jobs.ac.uk/job/DPK467/p...
jobs.ac.uk
Postdoctoral Research Associate in Computational Muscle Biology at King's College London
Discover Postdoctoral Research Associate in Computational Muscle Biology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
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Reposted by Fran Rodriguez-Algarra
Robert Seaborne @robertseaborne.bsky.social · 10/11/2025
Recruiting a comp PDRA for the lab 🚨 Working on multiple projects using integrated multi omics in bulk & single cell level Passion for data, coding, bioinformatics & keen to lead our labs comp workflow 12 months in first instance but extendable for further 19 months my.corehr.com/pls/coreport...
my.corehr.com
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Reposted by Fran Rodriguez-Algarra
Jeff Spence @jeffspence.github.io · 07/11/2025
How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...
nature.com
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
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Reposted by Fran Rodriguez-Algarra
Sarah Marzi @sj-marzi.bsky.social · 04/11/2025
@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS. Get in touch for any questions and apply by 2 December: my.corehr.com/pls/kclrecru...
Stained axons
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Reposted by Fran Rodriguez-Algarra
European Society of Human Genetics @eshg.bsky.social · 04/11/2025
New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬 A big step for precision medicine! www.nature.com/articles/s41...
nature.com
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database - Nature Communications
Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD),…
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Reposted by Fran Rodriguez-Algarra
Robert Seaborne @robertseaborne.bsky.social · 29/10/2025
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
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Reposted by Fran Rodriguez-Algarra
Dr Radu Zabet @raduzabet.bsky.social · 29/10/2025
Together with Chris Bell and Alexander Dawson, we are recruiting an PhD student (LIDo iCASE) at @qmulepigenetics.bsky.social to work on using long read nanopore technology to investigate DNA methylation on native DNA. This is a joint project with ONT. www.findaphd.com/phds/project...
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Reposted by Fran Rodriguez-Algarra
Robert Seaborne @robertseaborne.bsky.social · 25/09/2025
🚨Second position available in the lab. Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell. Please spread the word! kcl-mrcdtp.com/project/the-...
kcl-mrcdtp.com
The brain-muscle epigenetic interplay in neuromuscular disease - MRC DTP
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by progressive motor neuron loss. Emerging evidence suggests a critical, previously underappreciated role for skeletal muscle in ALS onset and progression, highlighting pathological and molecular interplay between brain and muscle. However, systematic, high-resolution molecular analyses across these tissues remain scarce. This project will use advanced […]
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Reposted by Fran Rodriguez-Algarra
Robert Seaborne @robertseaborne.bsky.social · 25/09/2025
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...
kcl.ac.uk
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
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Reposted by Fran Rodriguez-Algarra
Vikram Paralkar @paralkarlab.bsky.social · 02/08/2025
📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
biorxiv.org
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
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Reposted by Fran Rodriguez-Algarra
Adam Phillippy @aphillippy.bsky.social · 12/05/2025
NIH is allowing us to recruit postbacs and postdocs again. Please reach out if you are interested in working with us! Ad: genomeinformatics.github.io/jobs2025/
genomeinformatics.github.io
We are looking for postbacs and postdocs!
Join our team and contribute to the development of complete, personalized “telomere-to-telomere” (T2T) genome assemblies and the analysis of previously inaccessible regions of the genome! We are curre...
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Reposted by Fran Rodriguez-Algarra
QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 02/05/2025
Our next guest speaker webinar is happening next Friday, May 9th at 14:00 GMT. Omer Bayraktar will give a talk on: "Mapping the rules of glioblastoma using single cell and spatial multiomics". To join please follow the link below: www.qmul.ac.uk/epigenetics/...
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Reposted by Fran Rodriguez-Algarra
Faraz Mardakheh @handle.invalid · 16/04/2025
🧵1/ 🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
biorxiv.org
An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6
Intrinsically disordered regions (IDRs) are prevalent in RNA-binding proteins (RBPs), yet their roles in RNA interactions remain poorly defined. Here, we examined the structured and disordered RNA-bin...
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Reposted by Fran Rodriguez-Algarra
Dr Radu Zabet @raduzabet.bsky.social · 04/04/2025
I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
qmul-jobs.tal.net
Quick Check Needed
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Reposted by Fran Rodriguez-Algarra
Jacqueline S. Dron, PhD @jsdron.bsky.social · 18/03/2025
Just wanted to remind folks of the upcoming abstract submission deadline for the 2025 Human Genetics and Genomics GRS on March 30! 🧬 Come join us in beautiful Portland, Maine from July 5-6! Check out this link for more details: www.grc.org/human-geneti...
grc.org
2025 Human Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.
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Reposted by Fran Rodriguez-Algarra
QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 13/02/2025
We're excited to announce the official QMUL Centre for Epigenetics Launch Conference 2025! 🎉 To find out more and book your free ticket, please follow the link below: www.eventbrite.co.uk/e/qmul-centr... @qmul.ac.uk @bartscharity.bsky.social @qmulepigenetics.bsky.social
eventbrite.co.uk
QMUL Centre for Epigenetics Launch Conference 2025
Join us in celebrating becoming an official Centre for Epigenetics at QMUL!
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Reposted by Fran Rodriguez-Algarra
Stephen Curry @scurry.bsky.social · 11/02/2025
Members of the U.K. and international scientific community are invited to sign to show their support: docs.google.com/forms/d/e/1F...
docs.google.com
Open letter to the President of the Royal Society – time to stand up for your values
If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...
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Reposted by Fran Rodriguez-Algarra
Duncan Sproul @sproullab.bsky.social · 10/02/2025
Had the pleasure of hearing about this cool story from @rakyanlab.bsky.social and @franrodalg.bsky.social last summer, congrats to all involved.
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Rakyan Lab @rakyanlab.bsky.social · 08/02/2025
Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data! www.biorxiv.org/content/10.1...
biorxiv.org
Germline sequence variation within the ribosomal DNA is associated with human complex traits
The ribosome is one of the core macromolecules in the cell. The ribosomal RNAs (rRNA), which are essential components of the ribosome, are coded by the multi-copy ribosomal DNA (rDNA). Despite its hig...
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Faraz Mardakheh @handle.invalid · 05/02/2025
🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨
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Reposted by Fran Rodriguez-Algarra
QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 24/01/2025
QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here qmul-jobs.tal.net/vx/mobile-0/...
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Reposted by Fran Rodriguez-Algarra
QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 24/01/2025
@blizardinstitute.bsky.social, @qmulepigenetics.bsky.social is looking to recruit a senior lecturer with strong expertise in genomics/epigenomics/cell-free nucleic acids. Supported by @bartscharity.bsky.social to develop genomic and epigenomic liquid biopsy analyses for diagnostics.
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a grassland chase 🌾🌾🌾🌾 @chasesolidago.bsky.social · 23/01/2025
The world has been through anti-science cycles before, to disastrous results On a detour on my lit review, a mosey through the history of our familiar friend, the standard onion (Allium cepa) brought me right to one of botany's greatest cautionary tales of what happens when ideology overrides data
a illustration of our standard kitchen onion, Allium cepa, from 1586. Handcolored engravinga black and white photograph of a white man in a suit, holding stalks of some plant, possibly corn or some sort of grain. Photo depicts Nikolai Vavilov (1887 - 1943)
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QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 22/01/2025
🚨New review paper alert!🚨 At the @rakyanlab.bsky.social , we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes
Genetic variation within the multi-copy, multi-locus ribosomal DNA (rDNA) can contribute to human complex trait variability. This variation takes the form of copy number, structural arrangement, and ...
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Reposted by Fran Rodriguez-Algarra
Miguel Branco @brancolab.bsky.social · 21/01/2025
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.
qmul-jobs.tal.net
Postdoctoral Research Associate - QMUL Jobs
ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:
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Reposted by Fran Rodriguez-Algarra
Rakyan Lab @rakyanlab.bsky.social · 21/01/2025
Delighted to share the below perspective on human rDNA genetic variation on BlueSky. It’s an exciting, young field with lots of new stuff to discover! Plus, it is a prelude to a cool preprint from the lab that will be up soon. #ribosome #rRNA #rDNA
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Fran Rodriguez-Algarra @franrodalg.bsky.social · 21/01/2025
🚨New review paper alert!🚨 At the @rakyanlab.bsky.social, we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes
Genetic variation within the multi-copy, multi-locus ribosomal DNA (rDNA) can contribute to human complex trait variability. This variation takes the form of copy number, structural arrangement, and ....
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Reposted by Fran Rodriguez-Algarra
Sarah Marzi @sj-marzi.bsky.social · 11/12/2024
So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...
academic.oup.com
Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states
Abstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o
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Reposted by Fran Rodriguez-Algarra
Dr Radu Zabet @raduzabet.bsky.social · 10/12/2024
Congratulations to Dr Ines Hofer (co-sup Dr Matt Reeves) for passing her PhD viva yesterday (subject to minor corrections). Ines worked on how HCMV impacts hematopoiesis and found very interesting results. Many thanks to @louisakjames.bsky.social and Prof Joanna Parish for examining Ines.
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Miguel Branco @brancolab.bsky.social · 29/11/2024
Highlight on @alexdemendoza.bsky.social's latest fascinating work.
qmul.ac.uk
Scientists recreate mouse from gene older than animal life
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Centre de Regulació Genòmica (CRG) @crg.eu · 29/11/2024
Bacteria are known to develop antibiotic resistance through mutations in DNA or their ability to actively pump and transport antibiotics out of the cell. Alterations to chemical modifications in ribosomal RNA could emerge as another mechanism. Full study here: www.nature.com/articles/s41...
nature.com
Native RNA nanopore sequencing reveals antibiotic-induced loss of rRNA modifications in the A- and P-sites - Nature Communications
It remains unclear whether rRNA modifications can be naturally altered in response to antibiotics in bacteria. Here, the authors analyzed direct RNA nanopore sequencing data with an analytical pipelin...
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Centre de Regulació Genòmica (CRG) @crg.eu · 29/11/2024
E. coli modifies its ribosomes when exposed to widely used antibiotics, according to new research by @evamarianovoa.bsky.social. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of antibiotic resistance.
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Alex de Mendoza @alexdemendoza.bsky.social · 14/11/2024
SOX and POU are crucial Transcription Factors in animal development, believed to be innovations of this group. Here we find them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here 🧵: rdcu.be/d0dPN 1/6
rdcu.be
The emergence of Sox and POU transcription factors predates the origins of animal stem cells
Nature Communications - The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals...
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Fran Rodriguez-Algarra @franrodalg.bsky.social · 27/11/2024
🙌🙌🙌
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Joachim Goedhart @joachimgoedhart.bsky.social · 22/11/2024
Reminder to update the "social links" in your ORCiD profile with your Bluesky handle:
ORCiD profile screenshot
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Dorit Reiss @doritreiss.bsky.social · 23/11/2024
Warning to all: Dr. Peter Hotez is not on BSKY. This is a fake. (Repeating Dr. Hotez’ warning on Twitter).
Dr. Hotez’ tweet warning of the fake.
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Sean Flynn @seanflynn.bsky.social · 22/11/2024
If you are interested in #Epigenetics apply for a PhD with Jack Hardwick and Jonathan Hanley in Bristol, and our group in Exeter. Elucidating the role of DNA modifications in neurons Funded by #SWBio DTP Deadline: Dec 4 To apply: www.swbio.ac.uk/programme/ho...
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