Sign in

Julien Ochala

@droch.bsky.social
630 followers 550 following 95 posts

Associate Professor at the University of Copenhagen - bmi.ku.dk/english/research/exercise…

PostsRepliesMedia
Julien Ochala @droch.bsky.social · 17/02/2026
Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the support
biorxiv.org
062
Julien Ochala @droch.bsky.social · 10/02/2026
Very interesting study unravelling cardiac myofibrillar plasticity in the animal kingdom! Huge effort from colleagues at CU Boulder (with very humble contribution from our lab)
biorxiv.org
030
Julien Ochala @droch.bsky.social · 29/01/2026
Postdoc opportunity in our group in sunny Copenhagen ☀️ candidate.hr-manager.net/ApplicationI...
candidate.hr-manager.net
Postdoc in cardiac sarcomere biology at Department of Biomedical Sciences
Postdoc in cardiac sarcomere biology at Department of Biomedical Sciences  Faculty of Health and Medical Sciences University of Copenhagen We are looking f
020
Julien Ochala @droch.bsky.social · 16/01/2026
Our latest collaborative work highlighting an early cardiac myosin dysfunction in diabetic patients (even without any cardiomyopathy)! @ucph.bsky.social funded by @novo-nordisk.bsky.social
link.springer.com
Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus - Cardiovascular Diabetology
Background Type 2 diabetes mellitus (T2DM) predisposes patients to adverse cardiac remodeling even before the development of cardiomyopathic symptoms. The mechanisms for such early perturbations remai...
020
Julien Ochala @droch.bsky.social · 15/01/2026
Impressive study!
nature.com
Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer - Nature Metabolism
Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wast...
021
Reposted by Julien Ochala
JCI insight @insight.jci.org · 24/12/2025
When to target the most abundant protein in the heart? @droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....
021
Julien Ochala @droch.bsky.social · 18/12/2025
Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)
bmi.ku.dk
Ochala Group – University of Copenhagen
043
Julien Ochala @droch.bsky.social · 01/12/2025
Great collaborative work led by Christopher Toepfer and his team at the University of Oxford
nature.com
Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery - Nature Protocols
The Mant-ATP assay is a simple and accessible means for rapid quantitative assessment of the ratio of super-relaxed myosin to disordered relaxed myosin. This protocol provides a standardized methodolo...
1114
Reposted by Julien Ochala
Juan Martin Serrano @juanmartin-serrano.bsky.social · 24/11/2025
We are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP. www.kcl.ac.uk/jobs/131447-...
kcl.ac.uk
Reader in/Professor of Immunobiology | King's College London
044
Julien Ochala @droch.bsky.social · 23/11/2025
Top selling from pharma companies
010
Julien Ochala @droch.bsky.social · 22/11/2025
Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social
faseb.onlinelibrary.wiley.com
Cardiac Chamber‐Specific Regulation of Myosin Biochemical Super‐Relaxation and Auto‐Inhibition
The combination of Mant-ATP (2′-(or-3′)-O-(N-Methylanthraniloyl) Adenosine 5′-Triphosphate) chase experiments and all-atomistic molecular dynamics simulations, revealed that myosin auto-inhibition an...
001
Julien Ochala @droch.bsky.social · 13/11/2025
Excited to present our recent work on myosin as a molecular target for genetic muscle diseases! Kudos to all authors, especially Elise, Fanny and @myofinlab.bsky.social @ucph.bsky.social
insight.jci.org
JCI Insight - Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy
072
Julien Ochala @droch.bsky.social · 12/11/2025
Asterix and/et Ozempix
050
Reposted by Julien Ochala
Robert Seaborne @robertseaborne.bsky.social · 10/11/2025
Recruiting a comp PDRA for the lab 🚨 Working on multiple projects using integrated multi omics in bulk & single cell level Passion for data, coding, bioinformatics & keen to lead our labs comp workflow 12 months in first instance but extendable for further 19 months my.corehr.com/pls/coreport...
my.corehr.com
044
Julien Ochala @droch.bsky.social · 10/11/2025
Multilingualism protects against accelerated aging www.nature.com/articles/s43...
nature.com
120
Reposted by Julien Ochala
Robert Seaborne @robertseaborne.bsky.social · 29/10/2025
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
065
Julien Ochala @droch.bsky.social · 23/10/2025
We are grateful to Independent Research Fund Denmark for funding our new project aiming to understand and treat heart failure! The project will take place at @ucph.bsky.social
161
Reposted by Julien Ochala
International Society for Heart and Lung Transplantation (ISHLT) @ishlt.bsky.social · 30/09/2025
Ensure #ISHLT2026 will be next level. ▶️ Submit your science in the treatment of advanced #heart and #lung disease, #transplantation, #MCS, and #PVD by 📆 14 October: 🔗 bit.ly/4dLYGdn
011
Julien Ochala @droch.bsky.social · 29/09/2025
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
employment.ku.dk
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
044
Reposted by Julien Ochala
Robert Seaborne @robertseaborne.bsky.social · 25/09/2025
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...
kcl.ac.uk
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
068
Julien Ochala @droch.bsky.social · 25/09/2025
This trial has been stopped for strategic business reasons
reuters.com
Eli Lilly halts trial testing experimental muscle-preserving drug with Zepbound
Eli Lilly has halted a study of an experimental drug, designed to prevent obesity patients from losing too much muscle, due to strategic business reasons, according to a U.S. registry of clinical trials.
130
Julien Ochala @droch.bsky.social · 25/09/2025
Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social
kcl.ac.uk
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
066
Reposted by Julien Ochala
Matthew Alexander, PhD @mattmuscleguy.bsky.social · 04/09/2025
UAB and Children's of AL is looking for a new Division Director of Pediatric Neurology (come be one of my bosses!). We are consistently in the top 30 nationwide in Pediatric Neurology and have excellent subspecialties in: Epilepsy, Autism, and NMDs. Apply: tinyurl.com/y8d8duve
023
Reposted by Julien Ochala
Brian Umberger @brianumberger.bsky.social · 28/08/2025
Please repost! We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
biomch-l.isbweb.org
Tenure-track Faculty Position in Biomechanics (Open Rank), University of Michigan, Ann Arbor, MI, USA - Biomch-L
The School of Kinesiology (http://kines.umich.edu) at the University of Michigan invites applications and nominations for a tenure-track faculty position at the level of Assistant Professor, Associate...
03763
Reposted by Julien Ochala
Angela Andersen @angelaandersen.bsky.social · 28/08/2025
Such a great city for science and culture 🇨🇦💕
085
Reposted by Julien Ochala
Robert Seaborne @robertseaborne.bsky.social · 13/08/2025
Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!
2113
Julien Ochala @droch.bsky.social · 08/08/2025
What is the proportion of HFrEF and HFpEF patients with CKD? #cardiosky
131
Julien Ochala @droch.bsky.social · 29/07/2025
Application submitted to @novo-nordisk.bsky.social - 🤞 - on to next one now!
040
Reposted by Julien Ochala
Mathew Kiang @mathewkiang.com · 25/06/2025
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...
ki.se
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
1278277
Reposted by Julien Ochala
Katsu Funai @katsufunai.bsky.social · 21/07/2025
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
jobs.sciencecareers.org
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
02932
Reposted by Julien Ochala
Jan Lammerding - Lab @lammerdinglab.bsky.social · 16/07/2025
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC. Find more information and register at: events.faseb.org/event/Mechan... Submit abstracts by August 31, 2025. Please share and see you in October!
15418
Reposted by Julien Ochala
Frank Schnorrer @frankschnorrer.bsky.social · 10/07/2025
SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...
510042
Julien Ochala @droch.bsky.social · 04/07/2025
Our department @ucph.bsky.social is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!
jobportal.ku.dk
164414 Tenure Track Assistant Professor or Associate Professor of Biomedical Sciences
0127
Reposted by Julien Ochala
The Journal of Physiology @jphysiol.bsky.social · 02/07/2025
Damien M. Callahan presents this #TranslationalPerspective on the work of Laitila et al. linking altered structure and post-translational modification of Troponin T to dystonia in nemaline myopathies💭 ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
033
Reposted by Julien Ochala
EMBO @embo.org · 28/06/2025
Looking for a #LifeSciences postdoctoral #opportunity? 🧪 Have a look at the EMBO Postdoctoral Fellowships for internationally mobile scientists in #Europe and globally. Apply before 11 July: www.embo.org/funding/fell... #research #funding #postdoc
embo.org
Fellowships, grants and career support – Postdoctoral Fellowships – EMBO
Supporting internationally mobile postdoctoral researchers in Europe and around the world
02420
Reposted by Julien Ochala
Karolinska Institutet @ki.se · 18/06/2025
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
news.ki.se
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
03625
Reposted by Julien Ochala
Edgar N @edgarnollet.bsky.social · 17/06/2025
Check out our comprehensive review on #metabolism in #hypertrophiccardiomyopathy! Now published online in the Journal of Cardiovascular Aging
021
Julien Ochala @droch.bsky.social · 17/06/2025
Great review article on metabolism and HCM led by @edgarnollet.bsky.social #cardiosky
oaepublish.com
Metabolic alterations in human hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a highly common cardiomyopathy and is characterized by left ventricular hypertrophy and diastolic dysfunction. In half of the cases, HCM is associated with mutatio...
022
Reposted by Julien Ochala
Melissa Bowerman @bowermanlab.bsky.social · 13/06/2025
Last chance to register (attend online or in person) and/or submit an abstract to @sma-europe.bsky.social 1st International Clinical Care. Deadline is June 15th! Registration: na.eventscloud.com/ereg/newreg.... Abstract submission: na.eventscloud.com/eSites/sma20...
na.eventscloud.com
1st International Clinical Care Symposium on SMA
132
Reposted by Julien Ochala
Niels Jessen @njessen.bsky.social · 07/06/2025
Registration for the Joslin Diabetes Symposium 2025 is now open. Focus is on inter-organ and international communication and the event is supported by friends in Canada and Denmark (Steno-DK)! 🇫🇴🇨🇦🇺🇸🇬🇱🇩🇰 More info 👇 @novonordisk.bsky.social #Steno-DK #Joslin #Toronto joslinsymposium.org
joslinsymposium.org
Joslin Diabetic Symposium - Joslin Diabetic Symposium
The Joslin Diabetes Center presents the 2025 Joslin International Symposium, October 7–9, 2025 at the Joseph B. Martin Conference Center in Boston, Ma. This course is designed for a broad audience of ...
152
Julien Ochala @droch.bsky.social · 28/05/2025
Offre de stage Master 2 @ucph.bsky.social dans le domaine des maladies cardiaques #CardioSky
110
Reposted by Julien Ochala
Atul Deshmukh @adeshmukh.bsky.social · 27/05/2025
Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell. @annakrook.bsky.social @juleenrzierath.bsky.social @cbmr.science doi.org/10.1016/j.ce...
doi.org
Redirecting
3256
Reposted by Julien Ochala
Ken Campbell @cardiaccampbell.bsky.social · 20/05/2025
Great study - just showing the title for others.
Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy
221
Julien Ochala @droch.bsky.social · 20/05/2025
Very enjoyable collaboration with puzzling results on myosin and HCM @ucph.bsky.social @amsterdamumc.bsky.social @novo-nordisk.bsky.social
ahajournals.org
American Heart Association Journals
171
Reposted by Julien Ochala
Rafeeque Mavoor @rafeequemavoor.bsky.social · 13/05/2025
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
32679350
Julien Ochala @droch.bsky.social · 13/05/2025
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Here comes the sun: the central role of human and clinical physiology in the era of multi‐omics and inter‐organ crosstalk
Click on the article title to read more.
010
Reposted by Julien Ochala
Frank Schnorrer @frankschnorrer.bsky.social · 10/05/2025
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social www.science.org/doi/epdf/10....
34930
Reposted by Julien Ochala
Ken Campbell @cardiaccampbell.bsky.social · 10/05/2025
Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins. Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis doi.org/10.1016/j.ja...
Graphical abstract - cell mechanics, histology and western blots.
4102
Reposted by Julien Ochala
Diabetologia @diabetologiajnl.bsky.social · 07/05/2025
The most abundant skeletal muscle protein (myosin) becomes super-relaxed and energy-efficient in type 2 diabetes mellitus #T2D #DiabetesResearch link.springer.com/article/10.1... 🔓
link.springer.com
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
084
Reposted by Julien Ochala
Jibran Khokhar @drjkhokhar.bsky.social · 05/05/2025
Come join us at @westernuresearch.bsky.social as a Canada Excellence Research Chair! DM me with questions/interest about theme 2! Be a part of a strong and well-equipped (e.g., imaging, behaviour) neuroscience community! uwo.ca/research/cer... @westernuwin.bsky.social @westernubrainscan.bsky.social
uwo.ca
Canada Excellence Research Chair Positions
Western University, in vibrant London, Ontario, delivers an academic and student experience second to none.
14133