Pan et al. report tetraoxane-containing compounds WMK-1/2 as first-generation mitochondrial lipid peroxidation inducers that bypass GPX4- and retinol-mediated defenses to trigger a distinct “mito-ferroptosis” sub-pathway, demonstrating potent bioavailable tumor-suppressive activity across multiple in vivo models.

ALT: Surfer's Epic Wipeout: Ragdoll Dive

Iron is essential for brain health but can become harmful when dysregulated. Ayton et al. summarise recent clinical trial results showing negative effects

Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...

In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress and an increasingly heme- and iron-rich microenvironment. T cells adapt by limiting their iro...

We are excited to announce FerrOZtosis 2.0! Come join us on the 19th of September at the Florey for a day full of ferroptosis. Our international guest speaker is the co-discoverer of ferroptosis, Pro...

Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

Nature Reviews Neuroscience - The brain’s high lipid content, iron levels and oxygen metabolism uniquely predispose it to ferroptosis, an iron-dependent form of regulated cell death. In this...

Human mitochondrial ferritin protects against oxidative stress by detoxifying iron. Here, highly unusual iron-oxygen chemistry, involving formation of a mixed valent diiron site and a tyrosine radical...

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In...

Zheng and Zhang et al. identify N-acetyl-l-cysteine (NAC) and its enantiomer N-acetyl-d-cysteine (d-NAC) as direct reducing substrates of glutathione peroxidase 4 (GPX4). They further reveal a broad r...

Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes

Fan et al. report a role for PRMT5 in regulating GPX4 stability and ferroptosis sensitivity through arginine methylation, which may be targeted to inhibit tumour development.

a–c, Immunoprecipitation and immunoblotting analyses were performed with the indicated antibodies. Representative results from at least three independent experiments were shown. a,b, The indicated MDA-MB-231 were treated with the indicated peptides with or without IFNγ (25 ng ml−1) for 2...

This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...

Kojin Therapeutics, a startup attempting to develop new treatments using programmed cell death, left last month’s JP Morgan Healthcare Conference in a bind.

Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation