Reposted by Shashank MasaldanEric Topol @erictopol.bsky.social · 31/07/2026Less protein, more lifespan! A comprehensive review of the merits of protein restriction for healthy aging A flip from the proteinmaxxing craze cell.com/cell-press-b... 1618960
Reposted by Shashank MasaldanWEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 10/06/2026Dr Sylvie Callegari, recent winner of the Burnet Prize, shares her thoughts on artificial intelligence in research, who inspires her most and what she would do if she could redesign mitochondria from scratch. Read more: www.wehi.edu.au/news/a-futur... 042
Reposted by Shashank MasaldanCure Parkinson's @cureparkinsons.org.uk · 01/04/2026Everyone’s experience with Parkinson’s is different. But in the end, we are all connected by one simple goal - a cure. Through personal video testimonials, members of our community share the moment of their diagnosis and the challenges they've faced since. Listen to their stories: buff.ly/7YLabvC 023
Reposted by Shashank MasaldanWEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 22/03/2026WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field. Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social www.wehi.edu.au/news/new-enz... 23011
Reposted by Shashank MasaldanWEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 15/01/2026💡Solving decades-long mysteries with cryoEM. 💥Brilliant science + best tech = life-saving medical research. Shaping the future of health through bold new approaches. #ParkinsonsDisease 0157
Reposted by Shashank MasaldanThe Science of Parkinson's @scienceofpd.bsky.social · 30/12/2025Disturbing reading: "Using mainly public funds, the scientific community paid the 5 large publishers $1.06 billion in 4 years. And according to this estimate, the sum covers only the fees to publish open access studies" english.elpais.com/science-tech...english.elpais.comScientists paid large publishers over $1 billion in four years to have their studies published with open accessA study reveals that academic megajournals ‘Scientific Reports’ and ‘Nature Communications’ have cornered the market 165
Reposted by Shashank MasaldanWEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 25/11/2025Professor Melanie Bahlo and Dr Fei Wang, from the WEHI Parkinson’s Disease Research Centre are part of an international team working to find a blood-based biomarker for Parkinson’s, funded by $1.77m from the Michael J. Fox Foundation. www.wehi.edu.au/news/wehi-sc... 031
Reposted by Shashank MasaldanHarmit Singh Malik @harmitmalik.bsky.social · 23/11/2025Scientific journals: we don’t want you using generative AI because it makes shit up. Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote Same journal: AI cover art which makes no sense? Oooh! 519642
Reposted by Shashank MasaldanThe Australian Ubiquitin Summit @ausub.bsky.social · 21/11/2025Time to find out what’s the newest insight on the #ubiquitin-proteosome degradation system from our speakers: Shang-Te (Danny) Hsu, Yasushi Saeki, Indrajit Sahu, and Kylie Walters. While this is our last talk session of Day 2 at #AusUb2025, science goes on at the poster session… 051
Reposted by Shashank MasaldanThe Australian Ubiquitin Summit @ausub.bsky.social · 17/11/2025⏳Three days to go until #AusUb2025! What is Grant Dewson most looking forward to in the upcoming Ubiquitin Summit? 🤔 Perhaps the speakers? Perhaps the free coffee ☕️? Or perhaps the very British prospect of cloudy, sunless days at the beach☁️? Watch the video to find out! 083
Reposted by Shashank MasaldanThe Australian Ubiquitin Summit @ausub.bsky.social · 16/11/2025⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?). More interviews to come in the next few days so watch this space 😉 0127
Reposted by Shashank MasaldanThe Australian Ubiquitin Summit @ausub.bsky.social · 31/10/2025If not registered, do it soon! 👇 www.lorneubiquitin.orglorneubiquitin.orgThe Australian Ubiquitin Summit 2025 011
Reposted by Shashank MasaldanThe Australian Ubiquitin Summit @ausub.bsky.social · 31/10/2025📢 All ubiquitin aficionados! 📢 We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️ Are you ready for talking ubiquitin by the bay? 🗓️ 20-23 Nov 📍Mantra, Lorne, VIC Chaired by David Komander (@komanderlab.bsky.social) #AusUb2025 142
Reposted by Shashank MasaldanAustralasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · 11/08/2025🔬 Exciting news for the ferroptosis community! FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne. 📅 Abstract deadline: August 15 📍 Details & registration: lnkd.in/dn7imCzdlinkedin.comWe are excited to announce FerrOZtosis 2.0! | Scott AytonWe are excited to announce FerrOZtosis 2.0! Come join us on the 19th of September at the Florey for a day full of ferroptosis. Our international guest speaker is the co-discoverer of ferroptosis, Pro... 062
Reposted by Shashank MasaldanEric Topol @erictopol.bsky.social · 10/08/2025Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease? erictopol.substack.com/p/lithium-an... 1622249
Reposted by Shashank MasaldanSylvie Callegari @sylviecallegari.bsky.social · 31/07/2025🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social. Excited for the awards ceremony on Sept 3rd! @eurekaprizes.bsky.social @wehi-research.bsky.socialyoutube.comPINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific ResearchYouTube video by Australian Museum 0194
Reposted by Shashank MasaldanWEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 17/07/2025WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s. Read more👇 www.wehi.edu.au/news/new-par...wehi.edu.auNew partnership with Parkinson’s Research Foundation to accelerate Parkinson’s drug discoveryWEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s. 031
Reposted by Shashank MasaldanCarl Quintanilla @carlquintanilla.bsky.social · 04/06/2025NYT, Page One: “Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.” @nytimes.com 38783273368
Shashank Masaldan @masaldan.bsky.social · 11/04/2025I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today so all those living with Parkinson's get the support they need to live a full life. www.awalkinthepark.org.au/s/2900/5275/tawalkinthepark.org.auJoin me for A Walk in the ParkI am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today to help all those living w... 050
Shashank Masaldan @masaldan.bsky.social · 11/04/2025Really nice step forward towards off-the-shelf DA cell therapies for Parkinson's. 030
Reposted by Shashank MasaldanNature @nature.com · 10/04/2025Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease go.nature.com/4lqDT3wgo.nature.comBrain cells given an ‘invisibility cloak’ fix Parkinson’s symptoms in ratsNeurons engineered to evade the immune system could work as cell-replacement therapy. 07021
Reposted by Shashank MasaldanJeremy Berg @jeremymberg.bsky.social · 29/03/2025You may have seen that the incoming NIH director and his buddies started a new journal, The Journal of the Academy of Public Health (One clue: There is no recognized Academy of Public Health) www.science.org/content/arti...science.orgNew journal co-founded by NIH nominee raises eyebrows, misinformation fearsThe Journal of the Academy of Public Health claims to open up scientific communication. But its unusual editorial policies have some scientists concerned 13245123
Reposted by Shashank MasaldanKomander Lab @komanderlab.bsky.social · 13/03/2025Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex! @wehi-research.bsky.social 06513
Reposted by Shashank MasaldanEric Topol @erictopol.bsky.social · 13/03/2025More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention. www.science.org/doi/10.1126/... 439284
Reposted by Shashank MasaldanSylvie Callegari @sylviecallegari.bsky.social · 13/03/2025Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social 816856
Reposted by Shashank MasaldanWEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 13/03/2025World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons. www.wehi.edu.au/news/scienti...wehi.edu.auScientists solve decades-long Parkinson’s mysteryWEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition. 14717
Reposted by Shashank MasaldanThe Lancet @thelancet.com · 07/02/2025“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av 14627359
Reposted by Shashank MasaldanSylvie Callegari @sylviecallegari.bsky.social · 14/01/2025A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this! Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Original article: www.cell.com/molecular-ce...kwnsfk27.r.eu-west-1.awstrack.me 083
Reposted by Shashank MasaldanAniruddha Das @aniruddhad.bsky.social · 17/01/2025"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers. www.cell.com/molecular-ce...cell.comUbiquitin—A structural perspectiveUbiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec... 1123
Reposted by Shashank MasaldanRashmi Agrata @rashmiagrata.bsky.social · 17/01/2025New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social 15823
Reposted by Shashank MasaldanMicha Rapé Lab @micharapelab.bsky.social · 16/01/2025Many thanks to Sylvie Callegari @wehi-research.bsky.social for her beautiful spotlight describing our recent discovery of localized, and ROS-regulated, protein degradation at mitochondrial import gates! www.sciencedirect.com/science/arti...sciencedirect.comReacting to reductive stress at the mitochondrial import gateA byproduct of mitochondrial energy production is the generation of reactive oxygen species (ROS). Too much ROS is toxic, but ROS deficiency is equall… 043
Reposted by Shashank MasaldanJane Dudley @janedudley.bsky.social · 20/01/2025Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...cell.comUbiquitin—A structural perspectiveUbiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec... 1158