Sign in

Shashank Masaldan

@masaldan.bsky.social
66 followers 140 following 8 posts

Cell biologist with an interest in metal biology, #ferroptosis, cellular #senescence, #mitochondria and the role they play in #neurodegeneration. Postdoc @dewsonlab.bsky.social

PostsRepliesMedia
Reposted by Shashank Masaldan
Eric Topol @erictopol.bsky.social · 31/07/2026
Less protein, more lifespan! A comprehensive review of the merits of protein restriction for healthy aging A flip from the proteinmaxxing craze cell.com/cell-press-b...
1618960
Reposted by Shashank Masaldan
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 10/06/2026
Dr Sylvie Callegari, recent winner of the Burnet Prize, shares her thoughts on artificial intelligence in research, who inspires her most and what she would do if she could redesign mitochondria from scratch. Read more: www.wehi.edu.au/news/a-futur...
Dr Callegari posing for a photo
042
Reposted by Shashank Masaldan
Cure Parkinson's @cureparkinsons.org.uk · 01/04/2026
Everyone’s experience with Parkinson’s is different. But in the end, we are all connected by one simple goal - a cure. Through personal video testimonials, members of our community share the moment of their diagnosis and the challenges they've faced since. Listen to their stories: buff.ly/7YLabvC
023
Reposted by Shashank Masaldan
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 22/03/2026
WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field. Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social www.wehi.edu.au/news/new-enz...
Researchers standing in front of whiteboard with scientific information
23011
Reposted by Shashank Masaldan
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 15/01/2026
💡Solving decades-long mysteries with cryoEM. 💥Brilliant science + best tech = life-saving medical research. Shaping the future of health through bold new approaches. #ParkinsonsDisease
0157
Reposted by Shashank Masaldan
The Science of Parkinson's @scienceofpd.bsky.social · 30/12/2025
Disturbing reading: "Using mainly public funds, the scientific community paid the 5 large publishers $1.06 billion in 4 years. And according to this estimate, the sum covers only the fees to publish open access studies" english.elpais.com/science-tech...
english.elpais.com
Scientists paid large publishers over $1 billion in four years to have their studies published with open access
A study reveals that academic megajournals ‘Scientific Reports’ and ‘Nature Communications’ have cornered the market
165
Reposted by Shashank Masaldan
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 25/11/2025
Professor Melanie Bahlo and Dr Fei Wang, from the WEHI Parkinson’s Disease Research Centre are part of an international team working to find a blood-based biomarker for Parkinson’s, funded by $1.77m from the Michael J. Fox Foundation.  www.wehi.edu.au/news/wehi-sc...
031
Reposted by Shashank Masaldan
Harmit Singh Malik @harmitmalik.bsky.social · 23/11/2025
Scientific journals: we don’t want you using generative AI because it makes shit up. Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote Same journal: AI cover art which makes no sense? Oooh!
519642
Reposted by Shashank Masaldan
The Australian Ubiquitin Summit @ausub.bsky.social · 21/11/2025
Time to find out what’s the newest insight on the #ubiquitin-proteosome degradation system from our speakers: Shang-Te (Danny) Hsu, Yasushi Saeki, Indrajit Sahu, and Kylie Walters. While this is our last talk session of Day 2 at #AusUb2025, science goes on at the poster session…
051
Reposted by Shashank Masaldan
The Australian Ubiquitin Summit @ausub.bsky.social · 17/11/2025
⏳Three days to go until #AusUb2025! What is Grant Dewson most looking forward to in the upcoming Ubiquitin Summit? 🤔 Perhaps the speakers? Perhaps the free coffee ☕️? Or perhaps the very British prospect of cloudy, sunless days at the beach☁️? Watch the video to find out!
083
Reposted by Shashank Masaldan
The Australian Ubiquitin Summit @ausub.bsky.social · 16/11/2025
⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?). More interviews to come in the next few days so watch this space 😉
0127
Reposted by Shashank Masaldan
The Australian Ubiquitin Summit @ausub.bsky.social · 31/10/2025
If not registered, do it soon! 👇 www.lorneubiquitin.org
lorneubiquitin.org
The Australian Ubiquitin Summit 2025
011
Reposted by Shashank Masaldan
The Australian Ubiquitin Summit @ausub.bsky.social · 31/10/2025
📢 All ubiquitin aficionados! 📢 We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️ Are you ready for talking ubiquitin by the bay? 🗓️ 20-23 Nov 📍Mantra, Lorne, VIC Chaired by David Komander (@komanderlab.bsky.social) #AusUb2025
A poster advertising the Australian Ubiquitin Summit in Lorne from the 20th - 23rd of November. The logo of the conference, as well as a note that there is a Targeted Protein Degradation Day are displayed at the top of the poster. The rest of the poster contains a photo of the bay at Lorne, looking out from rock pools into the ocean. Sitting atop this image is a list of the invited speakers (available on the Lorne Ubiquitin website), and below a note that the meeting is being organised in conjunction with the International Symposium on Autophagy, held on the 16th - 20th of November.
142
Reposted by Shashank Masaldan
Australasian Cell Death Society (ACDS) @auscelldeathsoc.bsky.social · 11/08/2025
🔬 Exciting news for the ferroptosis community! FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne. 📅 Abstract deadline: August 15 📍 Details & registration: lnkd.in/dn7imCzd
linkedin.com
We are excited to announce FerrOZtosis 2.0! | Scott Ayton
We are excited to announce FerrOZtosis 2.0! Come join us on the 19th of September at the Florey for a day full of ferroptosis. Our international guest speaker is the co-discoverer of ferroptosis, Pro...
062
Reposted by Shashank Masaldan
Eric Topol @erictopol.bsky.social · 10/08/2025
Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease? erictopol.substack.com/p/lithium-an...
lithium ion trapped by beta-amyloid and the way to get around it
1622249
Reposted by Shashank Masaldan
Sylvie Callegari @sylviecallegari.bsky.social · 31/07/2025
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social. Excited for the awards ceremony on Sept 3rd! @eurekaprizes.bsky.social @wehi-research.bsky.social
youtube.com
PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research
YouTube video by Australian Museum
0194
Reposted by Shashank Masaldan
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 17/07/2025
WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s. Read more👇 www.wehi.edu.au/news/new-par...
wehi.edu.au
New partnership with Parkinson’s Research Foundation to accelerate Parkinson’s drug discovery
WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s.
031
Reposted by Shashank Masaldan
Carl Quintanilla @carlquintanilla.bsky.social · 04/06/2025
NYT, Page One: “Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.” @nytimes.com
38783273368
Shashank Masaldan @masaldan.bsky.social · 11/04/2025
I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today so all those living with Parkinson's get the support they need to live a full life. www.awalkinthepark.org.au/s/2900/5275/t
awalkinthepark.org.au
Join me for A Walk in the Park
I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today to help all those living w...
050
Shashank Masaldan @masaldan.bsky.social · 11/04/2025
Really nice step forward towards off-the-shelf DA cell therapies for Parkinson's.
030
Reposted by Shashank Masaldan
Nature @nature.com · 10/04/2025
Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease go.nature.com/4lqDT3w
go.nature.com
Brain cells given an ‘invisibility cloak’ fix Parkinson’s symptoms in rats
Neurons engineered to evade the immune system could work as cell-replacement therapy.
07021
Shashank Masaldan @masaldan.bsky.social · 02/04/2025
Absolutely appalling!
030
Reposted by Shashank Masaldan
Jeremy Berg @jeremymberg.bsky.social · 29/03/2025
You may have seen that the incoming NIH director and his buddies started a new journal, The Journal of the Academy of Public Health (One clue: There is no recognized Academy of Public Health) www.science.org/content/arti...
science.org
New journal co-founded by NIH nominee raises eyebrows, misinformation fears
The Journal of the Academy of Public Health claims to open up scientific communication. But its unusual editorial policies have some scientists concerned
13245123
Shashank Masaldan @masaldan.bsky.social · 22/03/2025
Absolute goosebump inducing visual!
050
Reposted by Shashank Masaldan
Komander Lab @komanderlab.bsky.social · 13/03/2025
Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex! @wehi-research.bsky.social
06513
Reposted by Shashank Masaldan
Eric Topol @erictopol.bsky.social · 13/03/2025
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention. www.science.org/doi/10.1126/...
439284
Reposted by Shashank Masaldan
Sylvie Callegari @sylviecallegari.bsky.social · 13/03/2025
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social
816856
Reposted by Shashank Masaldan
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 13/03/2025
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons. www.wehi.edu.au/news/scienti...
wehi.edu.au
Scientists solve decades-long Parkinson’s mystery
WEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition.
14717
Reposted by Shashank Masaldan
The Lancet @thelancet.com · 07/02/2025
“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av
A Lancet Editorial: “American chaos: standing up for health and medicine”
14627359
Reposted by Shashank Masaldan
Sylvie Callegari @sylviecallegari.bsky.social · 14/01/2025
A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this! Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Original article: www.cell.com/molecular-ce...
kwnsfk27.r.eu-west-1.awstrack.me
083
Reposted by Shashank Masaldan
Aniruddha Das @aniruddhad.bsky.social · 17/01/2025
"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers. www.cell.com/molecular-ce...
cell.com
Ubiquitin—A structural perspective
Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...
1123
Reposted by Shashank Masaldan
Rashmi Agrata @rashmiagrata.bsky.social · 17/01/2025
New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social
'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell
15823
Reposted by Shashank Masaldan
Micha Rapé Lab @micharapelab.bsky.social · 16/01/2025
Many thanks to Sylvie Callegari @wehi-research.bsky.social for her beautiful spotlight describing our recent discovery of localized, and ROS-regulated, protein degradation at mitochondrial import gates! www.sciencedirect.com/science/arti...
sciencedirect.com
Reacting to reductive stress at the mitochondrial import gate
A byproduct of mitochondrial energy production is the generation of reactive oxygen species (ROS). Too much ROS is toxic, but ROS deficiency is equall…
043
Reposted by Shashank Masaldan
Jane Dudley @janedudley.bsky.social · 20/01/2025
Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...
cell.com
Ubiquitin—A structural perspective
Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...
1158