iiinova — where your digital self keeps evolving

The EMBO Journal @embojournal.org · 02/10/2026

New review! Myrthe Klaver et al @demarialab.bsky.social reflect on the field of cellular #senescence and its continuing evolution, from initial discoveries to technology-driven conceptual transitions and the emerging era of targeted interventions #WeekendRead link.springer.com/article/10.1...

020

The EMBO Journal @embojournal.org · 01/10/2026

Issue 19! Highlight: The plasticity of Paneth cells Review: co-activator stepbrothers SAGA & ATAC Perforin-2 cytosolic antigen escape mechanism TAD hierarchies & cohesion zones Hox/Meis transcription & neural crest diversification Cover by Trowitzsch, Tampé et al link.springer.com/journal/4431...

001

The EMBO Journal @embojournal.org · 15/09/2026

Issue 18: Comment on timescale mismatch in anthropocene evolution Review: tRNA evolution in photosynthetic organisms Method: Engineering editopes to make tumor neoantigens Ribosome-associated protein quality control during CFTR synthesis Cover: Alessio Zippo et al link.springer.com/journal/4431...

022

The EMBO Journal @embojournal.org · 07/09/2026

Dynamic control of cell state transitions during tissue morphogenesis Elias Barriga et al @eliasbarrigalab.bsky.social review how gene expression, chromatin modifications & microenvironmental biophysical factors contribute to robust coordination of morphogenesis link.springer.com/article/10.1...

04015

The EMBO Journal @embojournal.org · 01/09/2026

Issue 17 Comment—bridging scRNA-seq discovery with in vivo genetics Local autophagy & brain-wide presynaptic remodeling RAD54L in nucleolar DNA damage response & rDNA stability Distinct in vivo roles of caspase-3 & -7 activation Cover: @wilhelmpalm.bsky.social et al link.springer.com/journal/4431...

032

The EMBO Journal @embojournal.org · 28/08/2026

From water to land: @guillaumehummel.bsky.social, David Pflieger, Alexandre Berr, Laurence Drouard review evolution of tRNA gene repertoires in photosynthetic organisms link.springer.com/article/10.1...

031

The EMBO Journal @embojournal.org · 18/08/2026

In our latest issue 16: Review: Revisiting nerve nets Telomeric replication inhibition reconstituted Dual Hippo regulation by PP2A Transcriptional control of Golgi biogenesis Cover by Marthiens, Basto and colleagues link.springer.com/journal/4431...

071

The EMBO Journal @embojournal.org · 14/08/2026

New review by @tlaszlo.bsky.social and colleagues: Step-brothers in arms, SAGA and ATAC co-activator complexes, use different strategies link.springer.com/article/10.1...

0157

The EMBO Journal @embojournal.org · 03/08/2026

ISSUE 15 Perspective: immunosuppressive neutrophils Review: cryptic lncRNA translation Method: scalable phosphotyrosine proteomics Resource: SenFlag senescence signature Assembly: RNA exosome, ATP synthase, SecYEG membrane protein insertase Cover: Ikuo Suzuki et al link.springer.com/journal/4431...

022

The EMBO Journal @embojournal.org · 31/07/2026

Redefining ecological opportunity for evolution in the Anthropocene: Lutz Becks, @reefgenomics.bsky.social and colleagues comment on the concept of timescale mismatch between the rates of environmental changes and evolutionary processes link.springer.com/article/10.1...

000

The EMBO Journal @embojournal.org · 24/07/2026

Looking for weekend reading? New review by @kei-jokura.bsky.social and @jekely.biologists.social.ap.brid.gy revisits nerve nets, their functional organization, and evolutionary implications link.springer.com/article/10.1...

194

The EMBO Journal @embojournal.org · 15/07/2026

ISSUE 14: Review on skin aging SPACA9 and MNMIP1 on spermatid manchette microtubules DNA damage-activated kinase in bacterial immunity MORC3 regulates interferon via tandem repeat enhancer Cover: Sekler, Shirihai and coworkers link.springer.com/journal/4431...

0132

The EMBO Journal @embojournal.org · 03/07/2026

How to tether descriptive ‘cell atlases’ to biological mechanisms? Bin Zhou proposes intersectional genetics as a novel cell-type-specific strategy for enhanced marker tracing and cell fate control in animals link.springer.com/article/10.1...

020

The EMBO Journal @embojournal.org · 01/07/2026

In issue 13: Review: roles of nonsense-mediated RNA decay New SUMO ligase in plant immunity Mitochondrial calcium uptake in Alzheimer’s progression Mechanosensitive FHL2 and microtubule-actomyosin crosstalk Cover: Zheng, Hu, Long et al link.springer.com/journal/4431...

041

The EMBO Journal @embojournal.org · 22/06/2026

New review: The identity crisis of cryptic lncRNAs – Leoš Valášek and colleagues discuss how and when non-coding RNAs translate into small peptides link.springer.com/article/10.1...

141

The EMBO Journal @embojournal.org · 15/06/2026

This week: are you attending #EESMicrotubules ℅ @events.embl.org? As always, our @embojournal.org cytoskeleton editor Ieva Gailite will be there too, and is looking forward to discussing your data with you!

031

The EMBO Journal @embojournal.org · 15/06/2026

Issue 12: Comment on spatial metabolomics Review: Host/transposable element coexistence Method: One-step generation of T-cell receptor knock-in mice Phase separation of bacterial transcription terminator Cover: Sabrina Chumpen, @dmitryshvarev.bsky.social et al link.springer.com/journal/4431...

082

The EMBO Journal @embojournal.org · 09/06/2026

Human immunosuppressive neutrophils: recent answers to old and new questions New Perspective Article by Patrizia Scapini, Marco Cassatella et al link.springer.com/article/10.1...

020

The EMBO Journal @embojournal.org · 08/06/2026

Issue 11 Highlight: Clean AIFM1 cut by OMA1 curtails respiration Review: Antibiotic-induced gut microbiome dysbiosis Peroxisome ether lipids & lysosomal exocytosis Substrate allostery rules prothrombinase processivity De nove piRNA immunity upon retrovirus insertion link.springer.com/journal/4431...

172

The EMBO Journal @embojournal.org · 30/05/2026

Remarkable: this splendid @embo.org cake prepared by the local organizers!

061

The EMBO Journal @embojournal.org · 30/05/2026

The end of a great meeting: #EMBOevents #EMBOtelomere Our editor @hvodermaier.bsky.social presents the @embojournal.org poster prize to winner Valeria Rubeo from @crcm.bsky.social - congratulations! meetings.embo.org/event/26-tel...

172

The EMBO Journal @embojournal.org · 21/05/2026

New review article: Jing-Dong Han and colleagues discuss mechanisms and evaluation of skin aging, as well as strategies for rejuvenation link.springer.com/article/10.1...

011

The EMBO Journal @embojournal.org · 19/05/2026

In issue 10: Convergent evolution of aerobic fermentation CIN promotes migration & invasion via EFEMP1 secretion SenSet resource defines cell-type specific senescence signatures ... Cover: @franbottanelli.bsky.social and colleagues link.springer.com/journal/4431...

0186

The EMBO Journal @embojournal.org · 18/05/2026

Host-transposable element coexistence: a matter of resistance, tolerance and trade-off Read this new review by Séverine Chambeyron, Charlotte Grimaud, Mikiko Siomi et al link.springer.com/article/10.1...

04027

The EMBO Journal @embojournal.org · 12/05/2026

Beyond quality control: Kun Tan and Miles Wilkinson review biological roles of nonsense-mediated RNA decay and how they may be targeted by therapeutic interventions link.springer.com/article/10.1...

000

The EMBO Journal @embojournal.org · 06/05/2026

New commentary in our Metabolism collection: Prasad Phapale @au.dk discusses design, pitfalls and data interpretation in spatial metabolomics link.springer.com/article/10.1...

030

The EMBO Journal @embojournal.org · 05/05/2026

Issue 9: Review: controls of quantitative gene expression and epigenetic memory Resource: Cancer cell responses to USP9x inhibitors Embryonic transposable element regulation by TBP Ki-67 shapes nucleolus via chromatin anchoring Cover: S. Nakamura, N. Koizumi et al link.springer.com/journal/4431...

010

The EMBO Journal @embojournal.org · 04/05/2026

Read our new Review Article on antibiotic-induced gut microbiome dysbiosis: Michael Knopp, Camille Goemans et al discuss risks and strategies for mitigation link.springer.com/article/10.1...

1155

The EMBO Journal @embojournal.org · 15/04/2026

ISSUE 8 Highlights: Feeder-free stem cell cultures Sperm age & RNA code Perspective: ensuring transcript fidelity in transgene expression Defining STI1 domain roles in ubiquilin Dual phage inhibition of bacterial virulence & defense Cover: Junichi Ikenouchi et al link.springer.com/journal/4431...

061

The EMBO Journal @embojournal.org · 10/04/2026

Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes @hittingerlab.bsky.social , @linder-surprise.bsky.social et al show how distinct genetic routes can converge on the same genetic outcome link.springer.com/article/10.1...

068

The EMBO Journal @embojournal.org · 10/04/2026

How come giant mimivirus virions retain icosahedral symmetry like smaller viruses? Chantal Abergel, Hugo Bisio @molbiolgv.bsky.social et al use bioinformatics, genetics & interactomics to elucidate spatial & functional organization of mimivirus virion morphogenesis link.springer.com/article/10.1...

042

The EMBO Journal @embojournal.org · 09/04/2026

A conserved leader–repeat hairpin prevents processing of the first CRISPR repeat, suppressing extraneous crRNA production and preserving Cas13-mediated immunity Chase Beisel @helmholtz-hiri.bsky.social and coworkers link.springer.com/article/10.1...

021

The EMBO Journal @embojournal.org · 01/04/2026

In ISSUE 7: Perspective: Molecular evolution of animal aging Review: eIF3 roles in cells and disease Sorting nexins & hybrid endosomal coats Purine metabolism supported by microcephaly protein WDR62 Cover: Biao Gong and colleagues link.springer.com/journal/4431...

050

The EMBO Journal @embojournal.org · 20/03/2026

Happening soon - meet our immunology editor Ioannis Papaioannou at @keystonesymposia.bsky.social #InnateImmunity in beautiful Banff! #KSInnateImmune26 hubs.la/Q03TCrHw0

022

The EMBO Journal @embojournal.org · 16/03/2026

Our cancer editor Daniel Klimmeck will be in Bergamo for the EACR Conference ‘The Tumour Ecosystem’, and is looking forward to learning about your work there! @helloeacr.bsky.social eacr.org/conference/t...

001

The EMBO Journal @embojournal.org · 16/03/2026

Our SPECIAL ISSUE on MOLECULAR EVOLUTION & ECOLOGY is out! Editorial: @yehumoran.bsky.social, @berndpulverer.bsky.social et al Reviews on Asgard archaea, epimutations, giant-virus/host dynamics, smartphone analogy for animal origins… …& many related primary articles link.springer.com/journal/4431...

0228

The EMBO Journal @embojournal.org · 05/03/2026

Asgard #archaea: have we found our microbial ancestors? New review (also for newcomers to the field!) by Christa Schleper and Thiago Rodrigues-Oliveira link.springer.com/article/10.1...

14926

The EMBO Journal @embojournal.org · 02/03/2026

Featured in issue 5: Mitotic entry—Bora takes Polo to Aurora Tyrosine kinase targeting in Tasmanian devil cancer—cover by Morrigl and colleagues Proteome/transcriptome uncoupling in cellular quiescence Unique compartmentalization of holocentric silkworm chromosomes link.springer.com/journal/4431...

This cover highlights the article Tyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancers by Anna Schönbichler, Andreas Bergthaler, Richard Moriggl and colleagues. Two independent transmissible cancers have emerged in the Tasmanian devil, DFT1 and DFT2. DFT1 is driven by ERBB and multikinase signalling, while DFT2 is driven by PDGFRA. Kinase targeting reveals emerging resistance and remarkable oncogenic pathway plasticity, supporting combination treatment for more durable control. The cover illustration shows Tasmanian devils affected by DFT1 and DFT2 in a Tasmanian landscape beneath the Aurora Australis.

(Cover concept by Anna Schönbichler, scientific illustration by SciStories)

041

The EMBO Journal @embojournal.org · 27/02/2026

Molecular #evolution of animal #aging: A field perspective explores the impact of evolution on aging and offers a multi-angle view on longevity variation across model organisms and environments link.springer.com/article/10.1...

0158

The EMBO Journal @embojournal.org · 17/02/2026

In issue #4: Perspective: Cancer as the parasite within Proteolysis in the cell cycle of an archaeon Client recruitment to the cytosolic Fe-S cluster assembly targeting complex Rhizosphere ROS recruit beneficial bacteria Cover: Weiguo Zou, Lijun Wang and colleagues link.springer.com/journal/4431...

031

The EMBO Journal @embojournal.org · 11/02/2026

Still a chance to register for @keystonesymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! Our @embojournal.org subject editor Ioannis Papaioannou is looking forward to joining you there! #KSInnateImmune26 hubs.la/Q03TCrHw0

021

The EMBO Journal @embojournal.org · 02/02/2026

In issue 3: Cover: Jie Luo and colleagues Review: roles of homologous recombination proteins in genome stability Method: bacterial ubiquitin ligase engineered for target identification and: ATG8 ligases in membrane repair Shaping somatic hypermutation patterns … link.springer.com/journal/4431...

141

The EMBO Journal @embojournal.org · 19/01/2026

The splice of life: Carissa Emerson Hunter & Yi Xing review how alternative splicing shapes regulatory and phenotypic evolution link.springer.com/article/10.1...

020

The EMBO Journal @embojournal.org · 19/01/2026

EJ Issue 2 for 2026: Review: Golgi adaptations in neurons Highlight: T-cell decoding strategies Method: In vivo proximity labeling with endogenous TurboID & mass spec Cover: Notch in glandular stem cells by @davidecinat.bsky.social and colleagues link.springer.com/journal/4431...

031

The EMBO Journal @embojournal.org · 16/01/2026

Cancer in disguise: a parasite within Perspective by Marek Wagner & Shigeo Koyasu explores mechanistic parallels between cancer and helminth infection, and how they might be leveraged for therapy link.springer.com/article/10.1...

020

The EMBO Journal @embojournal.org · 13/01/2026

Structural insights into the antibacterial function of the Pseudomonas putida effector Tke5 @pbernalt6ss.bsky.social, David Albesa-Jové and coworkers link.springer.com/article/10.1...

084

The EMBO Journal @embojournal.org · 13/01/2026

ROS generated in Arabidopsis roots recruit the beneficial rhizobacterium Pseudomonas anguilliseptica to promote plant growth and enhance pathogen resistance Yan Liang, Bin Ma and coworkers link.springer.com/article/10.1...

020

The EMBO Journal @embojournal.org · 12/01/2026

Ordering of cell cycle events by regulated proteolysis is not just for eukaryotes: @buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus Thanks to @reviewcommons.org for another #RefereedPreprint link.springer.com/article/10.1...

0149

The EMBO Journal @embojournal.org · 12/01/2026

Wenli Jiang et al show that turnover of the neuronal scaffold protein ARMS is regulated by autophagy, via a non-canonical ARMS interaction specifically with the Atg8-family GABARAP link.springer.com/article/10.1...

021

The EMBO Journal @embojournal.org · 12/01/2026

Diversity in mechanisms for epigenetic specification of vertebrate centromeres: Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C link.springer.com/article/10.1...

042