Face au changement climatique, les forêts vont-elles pouvoir nous sauver ? L’idée est rassurante, mais elle repose sur une mauvaise compréhension du cycle du carbone et de ce qu’est véritablement une ...

Centromeres in Arabidopsis thaliana evolve through frequent insertions and deletions of repeat units and increased rates of point mutations driven by homology-directed repair, a mutation spectrum that...

Increased RNA polymerase III (Pol III) activity and tRNA abundance are widely linked to cancer cell growth, yet the functional requirement for individual Pol III genes and core components remains uncl...

Mutant tRNA mistranslation is a phenomena in which specific tRNA gene mutations cause translational errors wherein amino acids incorporated during translation differ from those coded by mRNA sequences...

Duchenne muscular dystrophy (DMD) is a fatal disorder caused by loss of dystrophin, a protein essential for muscle cell integrity. To date, no therapeutic has restored full-length dystrophin. Suppress...

Photosynthetic eukaryotes have undergone evolutionary shifts from aquatic to terrestrial habitats, accompanied by changes in genome organization and gene regulation. Yet, the evolution of transfer RNA...

CRISPR-Cas systems are RNA-guided nucleases that enable prokaryotic immunity; however, some loci encode additional associated genes that cooperate with CRISPR effectors to perform diverse biological functions. Here, we uncover a CRISPR-associated kinase (CASK) system that links the recognition of target RNA to protein phosphorylation. We show that the kinase Csx33 phosphorylates Csx34 following activation of Cas13, enabling Csx34 to bind DNA in a sequence-specific manner. Together, Csx33 and Csx34 function as a transcriptional activation module that upregulates cas13 and associated genes, revealing a positive autoregulatory circuit that potentiates the immune response upon detection of foreign RNA. At the molecular level, Csx33 is activated by CCA trinucleotide RNA generated by Cas13-mediated cleavage of tRNA 3′ tails, uncovering a novel linear second messenger in bacterial immunity and a previously unrecognized signaling role of collateral RNA fragments. Together, these findings establish CASK systems as a new platform for RNA sensing and for engineering programmable phosphorylation-based signaling systems. ### Competing Interest Statement The authors have declared no competing interest. National Heart, Lung, and Blood Institute Division of Intramural Research, https://ror.org/023ny1p48, DP2-HL185100

Photosynthetic eukaryotes have undergone evolutionary shifts from aquatic to terrestrial habitats, accompanied by changes in genome organization and gene regulation. Yet, the evolution of transfer RNA...

In wheat, phosphorylation of the S-like RNase TaRNS4 mediated by the kinase TaRLK5 promotes its degradation of Puccinia striiformis f. sp. tritici RNA in the apoplast, enhancing resistance to stripe ...

How nuclear tRNA genes are organized across plant genomes remains largely unexplored. By comparing tDNA repertoires across 60 photosynthetic and non-photosynthetic eukaryotes, we show that coordinate...

Genes transcribed by the RNA polymerase (Pol) III of yeast are mostly found at sites of high transcription, genomic fragility, and replication fork stalling. Transcription terminator–dependent facilit...

A rice ribonuclease in roots promotes tolerance to phosphorus deficiency by recycling ribonucleic acids, offering a genetic target to develop crops with im

🔴📺 Il faut politiser la canicule et les feux de forêt. Le traitement médiatique du climat est à revoir ! Dans la perspective 2027, il est d’autant plus urgent que les médias placent le climat au coeur...

La situation agricole française n’est plus au bord du gouffre, comme elle pouvait l’être en 2022 : cette fois-ci, elle est dans le gouffre. Il n’est désormais plus inconcevable que nous soyons en trai...

It was the fifth such deal struck by the administration to get companies to drop offshore wind projects.

Bacterial reverse transcriptases defend against viruses, yet how their DNA products stop infection remains unknown. Bacteriophage inhibition of a host recombination enzyme activates the DRT3 defense s...

ExxonMobil’s own climate models showed that fossil fuel use would cause climate warming.

« Les entretiens de “Chaleur humaine” ». L’explorateur Christian Clot explique, dans un entretien issu de notre podcast consacré au défi climatique, comment nos corps et nos cerveaux affrontent les ép...

Drought and extreme heat are killing plants, driving up prices while also making some farms economically unviable

A transfer RNA (tRNA) was originally seen as a boring adaptor that brings amino acids to the ribosome during protein translation. A tRNA, with its distinct 2D cloverleaf structure, has an amino aci…

Combien de morts encore avant que le gouvernement n’adopte une loi d’urgence nous protégeant de l'hécatombe climatique? Signez cette pétition cruciale

[VIDÉO] Mélanie Vogel, sénatrice écologiste des Français de l'étranger, était l'invitée de la matinale de TF1 ce mardi. Elle est revenue sur l'adoption, par l'Assemblée nationale, de la loi d'urgence ...

Nature - A shift from nomadic lifestyles could have triggered linguistic diversity before it then declined rapidly.

Fire Information for Resource Management System

8 programmes européens dressent une feuille de route en quinze points pour enrayer l'effondrement des insectes pollinisateurs sauvages.

Transcription factor nanoclusters balance the DNA binding trade-off between weakly binding oligomers and nonspecific condensates.

Author summary Plants regulate gene expression in response to changes in day length, i.e., photoperiod, in order to coordinate growth and development. In previous studies, we showed that the precise p...

All organisms defend against viral infections through active immunity mechanisms that clear the virus or population-level mechanisms that cause regulated cell death. Recent research increasingly shows...

Bacterial defense systems provide a rich reservoir for biotechnological innovation. Retrons are tripartite abortive infection systems that detect phage invasion using reverse-transcribed DNA (msDNA), ...