Reposted by Hugo Bisio
Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis
dlvr.it
Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis
Estaras et al. identify stress granules (SGs) as a common stress response mechanism in acinar cells. In mutant KRAS-expressing cells, SGs are required for the development of preneoplastic lesions induced by this oncogene. Therefore, SGs represent a key vulnerability for KRAS-mutant cells during tumor initiation in PDAC.