Parast et al. reveal how abnormal transcription elongation factor expression could drive cellular senescence and aging via breakdowns in the coordination of transcription and RNA processing. They demo...

We present SenSeqNet, a deep learning framework that predicts cellular senescence directly from protein sequences. SenSeqNet integrates embeddings from the Evolutionary Scale Modeling(ESM-2) with a h...

In obese adipose tissue, p16⁺ endothelial cells and p21⁺ preadipocytes and immune cells exhibit high inflammatory activity, highlighting senescent cell heterogeneity. Clearing p16⁺ endothelial cells a...

Pharmacological restoration of p53 tumor suppressor function is a conceptually appealing therapeutic strategy for the many deadly cancers with compromised p53 activity, including lung adenocarcinoma (LUAD). However, the p53 pathway has remained undruggable, partly because of insufficient understandi …

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

We have validated the selective upregulation of LAMP1 in SEN in culture, and the percentage of Lamp1+ cells increases in various tissues with age, as well as in fibrotic lungs following BLM instillat...

Mitochondrial dysfunction is a feature of cellular senescence. Lai et al. find that senescent tumor cells release mitochondrial (mt)DNA into the extracellular space, where it is taken up by PMN-MDSCs....

Cell Death & Differentiation - Age-associated reduction in ER-Mitochondrial contacts impairs mitochondrial lipid metabolism and autophagosome formation in the heart

Senescent cells accumulate during aging and exhibit cell enlargement, the function of which has been unclear for decades. Here, the authors identify an antagonistic genetic circuit for hypertrophy and...

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Bi et al. propose the Senoreverse anti-aging strategy, which aims to reverse the proliferative arrest of senescent cells. Exosomal miR-302b is identified as a Senoreverse candidate that targets the ce...