iiinova — where your digital self keeps evolving

Chris Thorpe @drchristhorpe.bsky.social · 02/06/2026

These are just wonderful. Come on, allies, put your orders. I just have.

Chris Thorpe @drchristhorpe.bsky.social · 28/05/2026

For those of you wondering how ESMFold2 from the folks at @biohub.org performs on peptide:MHC complexes, their lovely API is currently running a test set. As I said before with ESMFold. Make APIs, it makes things easy for people to build on.

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British Society for Immunology @britsocimm.bsky.social · 22/10/2025

🚨 Today is a big day for #BSI25... two deadlines! 📝 Late breaking abstract submissions close tonight 💳 Early bird registration also ends today This is your last chance to present your work and secure your place at the best rate ➡️ bit.ly/3K6eFJz

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Robert Reich @rbreich.bsky.social · 06/10/2025

Journalist Edward R. Murrow used his platform on CBS to criticize the witch hunts led by Senator Joseph McCarthy in the 1950s. This is what real journalism should do — hold power to account, not capitulate to it.

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Adrian Liston @labliston.bsky.social · 06/10/2025

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Josh Hardy @joshuamhardy.bsky.social · 28/09/2025

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

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Chris Thorpe @drchristhorpe.bsky.social · 28/09/2025

I’ll just leave this here as it’s awesome in every way and very needed. Thank you Pulp and LCD Soundsystem. And of course Heaven 17 youtu.be/ydWHNkLtpcA

youtu.be

LCD Soundsystem & Pulp - (We Don’t Need This) Fascist Groove Thang, Hollywood Bowl, LA, CA 9-26-25

YouTube video by Prestoff2001

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Greifflab @victorgreiff.bsky.social · 28/09/2025

We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...

jobbnorge.no

PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo

Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025

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Senator Bernie Sanders @sanders.senate.gov · 26/09/2025

Labor productivity has more than doubled since the late 1960s. But workers’ compensation has barely budged. Yes. The economy is rigged in favor of the wealthy.

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Simon Dürr @handle.invalid · 25/09/2025

We are hiring a PhD student 🎓 Work with me and Matthias Rüdt in our department on an exciting industry collaboration with Lonza combining high-throughput experiments and molecular modelling using AlphaFold and MolecularDynamics 📍 Sion, Valais, Switzerland More info: www.jobup.ch/fr/emplois/d...

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Daphne Jackson Trust @daphnejacksontr.bsky.social · 24/09/2025

Investing in people behind medical research fuels UK growth. A new report by Frontier Economics (funded by @amrc-uk.bsky.social & @wellcometrust.bsky.social) shows non-commercial clinical research adds £72.7bn to the economy. Driving innovation in prevention, diagnosis & treatment. bit.ly/3KrW7nf

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Prof Danny Altmann @daltmann.bsky.social · 23/09/2025

Why did all of us never realise the greatest medical breakthroughs were this easy! Evidence from controlled studies with a sample size of millions falls away in thrall to a ‘feeling’ that it was the mothers’ ‘fault’ all along

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Adrian Liston @labliston.bsky.social · 19/09/2025

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

currentprotocols.onlinelibrary.wiley.com

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Chris Thorpe @drchristhorpe.bsky.social · 22/09/2025

Today I had to install Adobe InDesign, remind myself how to use it after almost 20 years and deliver files for printing in the space of 2 hours or the conference would not have had nice name badges. Underworld playlist helped. I'm also on holiday, so I then went for a walk in this heavenly place.

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British Society for Immunology @britsocimm.bsky.social · 15/09/2025

Immunology affects everyone. Join our new PPI Network to bring your voice into research & policy. No science background needed – just passion & lived experience. Applications close in 1 week. 🔗 bit.ly/3Jz7cT6

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Gina El Nesr @ginaelnesr.bsky.social · 12/09/2025

MLSB is coming to Copenhagen, DK 🎉 Submission is under the same portal, just simply indicate your location preference(s).

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Prof Christina Pagel @chrischirp.bsky.social · 11/09/2025

Really useful update from Bob Hawkins on Long Covid in England from the annual GP survey bhawkins3.substack.com/p/long-covid...

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Ewan Birney @ewanbirney.bsky.social · 09/09/2025

Thoughtful piece by Abdel on social science genetics - I am definitely taken by “one person’s confounder is another person’s signal”. Also humble about dark histories here and his own perspective

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Jamie Heather @jamieheather.bsky.social · 08/09/2025

This is a cool story that I've watched with great interest - making big steps in the field of de novo TCR generation! Great work @dkarthikey1.bsky.social / @benjamingvincent.bsky.social / @alexr.bsky.social et al

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Chris Thorpe @drchristhorpe.bsky.social · 08/09/2025

Very good piece from @dianecoyle1859.bsky.social on AI and future implications for the workplace at large, with context setting around the already existing digital divide. Thought provoking and insightful, I hope policymakers read it, re-read it and then have a really deep think/reset of policies

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Adrian Liston @labliston.bsky.social · 03/09/2025

On to the management of your grant! You need to keep track of your spending. Remember, you are expected to not just do what you promised, but also do what reviewers want, and create preliminary data for the next grant. This means you need to under-spend on the original deliverables.

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Diane Coyle @dianecoyle1859.bsky.social · 04/09/2025

This is very interesting

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British Society for Immunology @britsocimm.bsky.social · 04/09/2025

What can you expect at #BSI25 this December? 🌍 Prof Yasmine Belkaid’s keynote on microbiota & immunity 🧬 Six plenaries on cancer, autoimmunity, infection & more 🌟 Bright Sparks showcase of early-career talent ✨ & more! Read our programme spotlight: bit.ly/4g7RfPX

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Open Targets @opentargets.org · 04/09/2025

Last call to submit a project for the Open Targets Hackathon! Submit a project by 12 September: docs.google.com/forms/d/e/1F... We will prioritise projects where the project leads have signed up to attend the hackathon. Registrations are currently full but you can sign up to the waiting list

Open Targets Hackathon: one week left to submit a project

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Chris Thorpe @drchristhorpe.bsky.social · 04/09/2025

Brilliant advice from @labliston.bsky.social on creating/managing research budgets. So helpful and useful, thank you Adrian for sharing. 🫶

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British Society for Immunology @britsocimm.bsky.social · 03/09/2025

🚨 Final hours! Submit your abstract for #BSI25 by midnight TONIGHT. Present your work, win awards, and connect with over 1,500 peers. Don’t miss this last chance! 🔗 Submit here: bit.ly/3UfF6i5

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Chris Thorpe @drchristhorpe.bsky.social · 03/09/2025

Well, that's my abstracts for @britsocimm.bsky.social Congress submitted, and I'm delighted to be included in a couple of other abstracts. Looking forward to Liverpool and seeing folks and discussing the work in person. One of the best parts of it all.

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Suw @suw.bsky.social · 03/09/2025

“This may be the cutest way to improve your Welsh. The book covers a dozen garden birds which each have a lovely picture to introduce them [...], followed by a short description of appearance and behaviour." Adar yr Ardd, my illustrated ebook, is just £1.99 from seidrpress.com #DysguCy...

An illustration of a male greater spotted woodpecker, which has been labelled in Welsh.

The ebook cover, featuring illustrations of trees with a blue tit, robin and great tit. The text says: Adar yr Ardd, Suw Charman-Anderson, Llyfr Bach ar gyfer Dysgwyr.

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Rayan Chikhi @rayanchikhi.bsky.social · 03/09/2025

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...

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Martin Lewis @martinlewis.moneysavingexpert.com · 02/09/2025

Expect your mobile to go off 3pm Sunday! Be prepared for a test of the Govt's emergency alert system. Full info... www.moneysavingexpert.com/news/2025/09... LIVING WITH DOMESTIC ABUSE? If you've a hidden mobile, you the link above has details of how to opt out of the alert. Pls share

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EMBL @embl.org · 01/09/2025

📢 Recruitment for the EMBL International PhD Programme is officially open! At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences! bit.ly/47mmiFF

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Simon Willison @simonwillison.net · 29/08/2025

"Spooky fuzzy databases" is pretty accurately too bsky.app/profile/gree...

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Simon Willison @simonwillison.net · 29/08/2025

An LLM is a lossy encyclopedia simonwillison.net/2025/Aug/29/...

Since I love collecting questionable analogies for LLMs, here's a new one I just came up with: an LLM is a lossy encyclopedia. They have a huge array of facts compressed into them but that compression is lossy (see also Ted Chiang).

The key thing is to develop an intuition for questions it can usefully answer vs questions that are at a level of detail where the lossiness matters.

This thought sparked by a comment on Hacker News asking why an LLM couldn't "Create a boilerplate Zephyr project skeleton, for Pi Pico with st7789 spi display drivers configured". That's more of an lossless encyclopedia question!

My answer:

The way to solve this particular problem is to make a correct example available to it. Don't expect it to just know extremely specific facts like that - instead, treat it as a tool that can act on facts presented to it.

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Ewan Birney @ewanbirney.bsky.social · 29/08/2025

An evergreen thread: Race/Ethnicity is *not the same* as genetics, and you can't use Race/Ethnicity as a sort of stand-in for genetics. These two concepts are connected via aspects like skin colour, but the connection is alot less profound and categorical than most people think.

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Chris Thorpe @drchristhorpe.bsky.social · 21/08/2025

Calling all #Tcell #immunologists. 📰 Latest news update! 🗞️ As many of you may have seen, we're running a conference and hackathon in Oxford in late-September/early-November. It's getting close, just over a month away now! ⏰ web.cvent.com/event/7466b0...

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Nick Borcherding @thehumanborch.bsky.social · 20/08/2025

Excited to announce ImmReferent - A one stop shop for getting and handling IMGT immune receptor and HLA sequences in R. github.com/BorchLab/imm...

github.com

GitHub - BorchLab/immReferent: An Interface for Immune Receptor and HLA Gene IMGT Reference Data

An Interface for Immune Receptor and HLA Gene IMGT Reference Data - BorchLab/immReferent

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Emily Hunt @emily.space · 15/08/2025

I really dislike how science has started calling almost any fancy computational technique AI. 🧪 The framing of this entire article makes it sound like a benevolent AI independently made these drugs. That is *pure fantasy*. Instead: a team of scientists made a machine learning model for a study.

Article on BBC news.
Title: AI designs antibiotics for gonorrhoea and MRSA superbugs
Description: Two new potential drugs have been designed by AI to kill drug-resistant bacteria, in a major Massachusetts Institute of Technology study.

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Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 11/08/2025

Thanks for the visit Nobel laureate John Jumper & colleagues Kathryn Tunyasuvunakool and Lindsay Willmore from Google DeepMind. Always interesting to hear and discuss #AlphaFold and protein structure predictions.

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Kate Bevan @katebevan.com · 27/07/2025

Just goes to show that if you want it brought home, you need to get the women to do it #TheFootball

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Chris Thorpe @drchristhorpe.bsky.social · 27/07/2025

LIONESSES! So brilliant. Well done, what a team.

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Tobias Marschall @tobiasmar.bsky.social · 23/07/2025

Two papers in today's issue of @nature.com ‬: 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.

tinyurl.com

Complex genetic variation in nearly complete human genomes - Nature

Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

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Adrian Liston @labliston.bsky.social · 24/07/2025

The day Trump won I said I wasn't going to visit the US under a Trump presidency. If you don't have to visit, don't. Don't support Trump, don't take the risk.

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Andrew White 🐦‍⬛ @andrew.diffuse.one · 23/07/2025

HLE has recently become the benchmark to beat for frontier agents. We at FutureHouse took a closer look at the chem and bio questions and found about 30% of them are likely invalid based on our analysis and third-party PhD evaluations. 1/7

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Waggoner Lab @labwaggoner.bsky.social · 23/07/2025

Structural variation in the human genome @nature.com nature.com/articles/s41... nature.com/articles/s41... @tobiasmarschall.bsky.social

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