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Dagan Segal

@dagansegal.bsky.social
898 followers 1.3K following 59 posts

quantitative imaging in pediatric cancer. postdoc @Danuser Lab, UTSW Find me at dagansegal.bsky.social

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Reposted by Dagan Segal
Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 07/05/2026
For those interested 🧪
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Dagan Segal @dagansegal.bsky.social · 07/05/2026
Exciting new SciArt initiative by ZDMS 🐟 🖼️ Please share with anyone who may be interested, we would love to see broad engagement!
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Reposted by Dagan Segal
Itai Yanai @itaiyanai.bsky.social · 26/03/2026
Can you help us find guests for the Night Science Podcast? We received generous sponsorship from Research Theory and they're challenging us to host 5 scientists each working in flight, genomics, nuclear power, computing & space. Ideas? @nightsciencepod.bsky.social podcasts.apple.com/us/podcast/n...
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Dagan Segal @dagansegal.bsky.social · 26/03/2026
Avi Loeb!
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Dagan Segal @dagansegal.bsky.social · 17/10/2025
Hi Henry, welcome to UTSW and congrats on the new position! Will be so cool to have you around
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Dagan Segal @dagansegal.bsky.social · 08/10/2025
hi @zebrafishrock.bsky.social community! Who of my friends am I going to see at ZDM18 in Boston next week?!? Excited!
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Reposted by Dagan Segal
Miranda Hunter @mrndhntr.bsky.social · 27/08/2025
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
nature.com
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
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Frank Schnorrer @frankschnorrer.bsky.social · 29/08/2025
Females are larger than males. How? Here is one solution- they have MORE nuclei in their flight muscles and grow LARGER heart and fat body cells with MORE ribosomal mRNAs. Fun collaboration of @jeromeavellaneda.bsky.social with @soumitrakp.bsky.social & Brian Oliver www.biorxiv.org/content/10.1...
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Reposted by Dagan Segal
Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 28/08/2025
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.
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Soragni:Lab @alice.soragnilab.com · 26/08/2025
Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv! This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵 🔗 www.biorxiv.org/content/10.1...
biorxiv.org
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...
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Dagan Segal @dagansegal.bsky.social · 26/08/2025
This @nightsciencepod.bsky.social episode with Martin Schwartz was so awesome! The idea to toss all the "ego" aspects of science (including worries/insecurities about career prospects) and follow the curiosity/passion path to do your best work is something I strive for every day.
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Dagan Segal @dagansegal.bsky.social · 26/08/2025
What an exciting announcement! Best of luck to @itaiyanai.bsky.social and Martin Lercher on this new endeavor. The cultural shift is much needed. I am on board!
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Dagan Segal @dagansegal.bsky.social · 21/08/2025
Now online! www.youtube.com/channel/UCs9...
youtube.com
BPPB Seminar
Founded during the pandemic and maintained by a rotating team of volunteers from the biological physics / biophysics community, the BPPB (Biological Physics / Physical Biology) Seminars provide a mean...
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Reposted by Dagan Segal
Stowers Institute @stowersinstitute.bsky.social · 12/08/2025
🎉 Congrats to postdoc Horacio Martín Pallarés on being named a 2025 @pewtrusts.org Latin American Fellow! His work in the @bazzinilab.bsky.social (a 2010 PEW Fellow) investigates how #Zika & #dengue viruses hijack host cells. Read about the fellowship and full circle moment: bit.ly/4mHWJTS
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Dagan Segal @dagansegal.bsky.social · 12/08/2025
I keep getting more and more followers here but i think they are mostly bots, right?
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Dagan Segal @dagansegal.bsky.social · 11/08/2025
Congrats Kolade and team!
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Reposted by Dagan Segal
Rodrigo Fernandez-Gonzalez @rodrigofg.bsky.social · 11/08/2025
To celebrate the summer, our ReSCU-Net paper is out @jcb.org !! Work led by our dungeon master @ray-hawkins.bsky.social, developing a novel neural network architecture and applying it to explore the role of gap junctions in embryonic wound healing in #Drosophila 🧪. shorturl.at/xNRKn
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Dagan Segal @dagansegal.bsky.social · 08/08/2025
This already happened and I wasnt on top of posting 😅 Thankful for the great opportunity to share my work at @bppbseminar.bsky.social .This is such an engaging and fun community and seminar series, highly recommend! Stay tuned for a recording (they are also on top of their youtube channel!).
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Dagan Segal @dagansegal.bsky.social · 24/07/2025
Time to find creative new ways to fund science!
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Dagan Segal @dagansegal.bsky.social · 23/07/2025
Very cool work using zebrafish model to bring new insight into pediatric cancer initiation! Congrats @jackkucinski.bsky.social @kendalllab.bsky.social and team!
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Dagan Segal @dagansegal.bsky.social · 26/05/2025
Very cool thread on something I knew very little about!
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Dagan Segal @dagansegal.bsky.social · 21/05/2025
Ha! I agree!
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Dagan Segal @dagansegal.bsky.social · 15/05/2025
what is it?
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Dagan Segal @dagansegal.bsky.social · 14/05/2025
Such cool work! Check out this recent paper by my colleague @jamieson-ai.bsky.social et al. with immediate real-world impact!
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Reposted by Dagan Segal
Young Embryologist Network @yen-network.bsky.social · 29/04/2025
REMINDER: Last chance to submit a scientific picture or art of a embryos, stem cells or organoids to the YEN Image Competition. Deadline is 1st May! #YEN2025
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Dagan Segal @dagansegal.bsky.social · 17/04/2025
Benny was my PhD mentor. Infectious enthusiasm and burning curiosity is exactly right. He was such a great mentor to me and many others and he will be sorely missed. יהיה זכרו ברוך. May his memory be a blessing.
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Dagan Segal @dagansegal.bsky.social · 16/04/2025
Hey @drlizhaynes.bsky.social Thanks for representing! (Not tattooed myself but respect the art of self expression :)) www.nature.com/articles/d41...
nature.com
Science on our sleeves: the research that inspires our tattoos
Inked scientists choose scientific images to mark career accomplishments and illustrate their research passion.
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Auke-Florian 🪹 @aukeflorian.nl · 09/04/2025
NEW PAPER, JUST OUT! 👀 Insects from the '70s and '80s were already collecting microplastic, decades before the term microplastic even existed. 🤯 A thread on the surprising history of this pollutant and the incredible insect larvae that helped us uncover it. 🐛 Let's dive in! 🧵👇 1/x
Lead author Auke-Florian Hiemstra holds the oldest known caddisfly casing containing microplastic, dating to 1971. Photo: Liselotte Rambonnet.A caddisfly casing with pieces of blue microplastic, dating 1986. Photo: Auke-Florian Hiemstra
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Jeremy Baskin @jeremybaskin.bsky.social · 03/04/2025
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
cell.com
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...
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Reposted by Dagan Segal
Sam Connell @samuelconnell.3i.social · 01/04/2025
Talks...on the train! What? @odedrechavi.bsky.social, @natanellae.bsky.social, @meital.bsky.social, @svobodalab.bsky.social, @paveltomancak.bsky.social, @itaiyanai.bsky.social, @zernickagoetz.bsky.social Register now for: "an atmosphere of enthusiasm, lucid criticism, nonconformism, and friendship".
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Dagan Segal @dagansegal.bsky.social · 22/03/2025
Outer ear = gills! First step towards creating human mermaids🧜‍♀️🌊
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Dagan Segal @dagansegal.bsky.social · 21/03/2025
Look who's on bluesky! I recommend you follow @assafzaritsky.bsky.social
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Dagan Segal @dagansegal.bsky.social · 21/03/2025
Hello Assaf! Good to see you here :)
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Reposted by Dagan Segal
Janelia Research Campus @hhmijanelia.bsky.social · 21/03/2025
📢 #AI & #CellularPhysiology researchers 👉 tune in via Zoom March 30-April 1 for a free livestream of our conference on the emerging intersection of AI and biological research. Topics will range from AI-driven genomic insights to dataset challenges & more. 🔗Register to watch: janelia.news/register
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Maik Bischoff @maikbischoff.bsky.social · 28/02/2025
Wow! 😍
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Dagan Segal @dagansegal.bsky.social · 19/02/2025
Happy birthday John! 30 is the new 20
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Franciska de Vries 🟥 @frantecol.bsky.social · 11/02/2025
On #InternationalDayofWomenandGirlsinScience let me remind you that we are NOWHERE NEAR parity. A few examples. 1. Women are credited less in science than men. www.nature.com/articles/s41...
nature.com
Women are credited less in science than men - Nature
The difference between the number of men and women listed as authors on scientific papers and inventors on patents is at least partly attributable to unacknowledged contributions by women scientists.
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Johanna Joyce @johannajoyce.bsky.social · 11/02/2025
Happy International Day of Women and Girls in Science! Its been a privilege to work with these extraordinary scientists in my lab over the years - all making an incredible impact throughout the world 🙌 We must never give up on #equality #diversity & #inclusion 💪 #WomeninScience #GirlsInSTEM 🧪🔬🔭🚀
Composite image of women scientists from the Joyce lab over the past 20 years
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Dagan Segal @dagansegal.bsky.social · 11/02/2025
This sounds like such a cool meeting!!
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Dagan Segal @dagansegal.bsky.social · 11/02/2025
Why are people putting "NIH" in quotes? Sorry I cant keep up with online trends, please advise :D
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Dagan Segal @dagansegal.bsky.social · 11/02/2025
my daughter is now a huge harry potter fan so Im reliving the joy :D
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Dagan Segal @dagansegal.bsky.social · 29/01/2025
Thanks @zebrafishrock.bsky.social !
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
12/n This is my first long thread on bluesky- would be happy to engage in further discussion and hear your thoughts!
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
11/n This was a super collaborative project incorporating many different methods- so lots of people to thank! My mentors Gaudenz Danuser and @amatrudalab.bsky.social , Danuser and @retof.bsky.social Labs, and several other groups at UTSW that are not yet on bluesky 😀
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
10/n This is the cliffs notes version- please check out the preprint to see more! www.biorxiv.org/content/10.1...
biorxiv.org
Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma
Cellular plasticity is a hallmark function of cancer, but many of the underlying mechanisms are not well understood. In this study, we identify Caveolin-1, a scaffolding protein that organizes plasma ...
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
9/n This led us to a model where: ✳️ caveolae offer stable docking points for active PI3K to spread, inducing survival signaling in CD99 High cells. ✳️CD99 low cells don't have caveolae and must find other ways to regulate their signaling, leaving them at a disadvantage in certain contexts.
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
8/n Using tools developed for quantitative 3D analysis- we saw that CD99 High cells had uniform active PI3K organization, which was lost upon knockdown of Caveolin-1!!
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
7/n - So what is Caveolin-1 doing? We noticed CD99 High cells also had upregulated PI3K/Akt activity - we thought Caveolin-1/caveolae could be responsible for organizing PI3K signaling on the cell surface. So we turned to 3D imaging of active PI3K. What we saw was really exciting!
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
6/n- The CD99 High cells also ✳️ look CRAAZZY in fish xenografts👇 ✳️show survival advantages in fish and mice ✳️show Caveolin-1 dependent survival advantage in response to chemotherapeutic drug (check out preprint for bullets 2 and 3!)
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Dagan Segal @dagansegal.bsky.social · 28/01/2025
5/n- second observation: these cells look really different also under and electron microscope! The CD99 High cells have a ton of caveolae (e.g. "little caves" along the membrane) and higher expression of the structural caveolar component Caveolin-1 .
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