Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

Major Finding: Mechanical confinement governs phenotype switching from a proliferative to an invasive state. Concept: Stable changes in chromatin architecture in mechanically confined cells induce can...

Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...

As the U.S. slashes funding to its research initiatives, there is a chance for us to recruit the best talent from around the world

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...