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Jack Kucinski

@jackkucinski.bsky.social

43 followers 61 following 5 posts

Ph.D. Candidate at The Ohio State University and Nationwide Children’s Hospital

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Reposted by Jack Kucinski

chinmay-sankhe.bsky.social @chinmay-sankhe.bsky.social · 09/04/2026

Grateful to the @americancancersoc.bsky.social for awarding me with the postdoctoral fellowship. Thanks to my mentor @kendalllab.bsky.social and other collaborators for supporting me and I'm excited to contribute to pediatric cancer research and improving patient outcomes in infants and children.

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Jack Kucinski @jackkucinski.bsky.social · 23/02/2026

🥳 Our preprint is LIVE 🥳 Huge thanks to Lex Tallan and the Stanton lab for another fantastic collaboration! Here, we use zebrafish and MNase-based methodology to show that PAX3::FOXO1 and PAX7::FOXO1 have divergent capabilities for interacting with repressive chromatin states and nucleosomal DNA.

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Jack Kucinski @jackkucinski.bsky.social · 23/07/2025

I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...

cell.com

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function...

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