Reposted by Prof Cynthia Whitchurch FAA🏳️🌈
Here's a nice article from Lynne Howell,
@dr-lori-burrows.bsky.social @brunlabcaulo.bsky.social
and colleagues. @mattmccallum.bsky.social made significant contributions to this story during his grad work, and @cwhitch.bsky.social originally identified PilT, the retraction ATPase.
nature.com
Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly - Nature Communications
The bacterial Tad pilus extends and retracts using a single bifunctional ATPase CpaF. Here, the authors employ cryo-EM, fluorescent microscopy, and AlphaFold modelling to propose how a rotary mechanis...