To mark International Women’s Day on 8 March, Mangala Srinivas reminds junior colleagues that career success won’t protect you from gender-based bias.

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Low rate of R&D investment plays key role in productivity crisis, according to Council of Canadian Academies

Author summary Type IV pili enable Pseudomonas aeruginosa to attach to surfaces, move (twitch), and form biofilms. Pilus extension is powered by the motor protein PilB, which is regulated by other fac...

The ability of bacteria to sense and respond to contact with surfaces is important for triggering changes in secondary messenger levels and gene expression, leading to the formation of biofilms and in...

In Pseudomonas aeruginosa, retractable protein filaments called type IV pili (T4P) facilitate surface adherence, sensing, and directional movement known as twitching motility. T4P are necessary for th...

The bacterial Tad pilus extends and retracts using a single bifunctional ATPase CpaF. Here, the authors employ cryo-EM, fluorescent microscopy, and AlphaFold modelling to propose how a rotary mechanis...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

We are bombarded by messages telling us to worship the gods of efficiency and optimization, life hacking our way to prosperity. It's a trap. Resilience is a smarter, sturdier goal.

Registration and abstract submission open on January 15th, 2025.The organizers will select the final list of participants based on abstract submission, particularly for young scientist, and the applic...

Populations of a single bacterial species can possess a great diversity of type VI secretion systems (T6SSs) and secreted effectors. Here, Habich et al. apply molecular population genetics to the T6SS...

The time for urgency, the experts say, is now.

A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.

Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

<span><i>Pseudomonas aeruginosa</i> is a bacteria responsible for many hospital-acquired infections. Phages are promising alternatives for treating <i>P. aeruginosa</i> infections, which are often intrinsically resistant. The combination of phage and antibiotics in clearing bacterial infection holds promi</span> …

Expression of VIM-2 leads to physiological trade-offs for bacterial pathogens that can be exploited to treat infections caused by multidrug-resistant bacteria.

Significant reductions in methicillin resistance in S aureus, vancomycin-resistant E faecium, and fluoroquinolone resistance across multiple pathogens suggest that control efforts have had an effect on resistance. The rise in extended-spectrum β-lactamases-producing Enterobacterales and recent surge in hospital-associated infections emphasise the need for ongoing surveillance and interventions. Our study highlights how coupling the analysis of phenotypic incidence with resistance proportion can enhance interpretation of antimicrobial resistance data.

Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag

Some scientists examining mutations found in H5N1 viruses fear major outbreak is imminent but others says pathogen remains unpredictable