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Alper Akay

@alperakay.bsky.social
1.7K followers 1.8K following 277 posts

UKRI Future Leaders Fellow / Group Leader. RNA (epi)Genetics of C. elegans. Views are my own. Likes and re-posts are not necessarily for endorsement. www.theakaylab.com

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Reposted by Alper Akay
John Stott @jpsastro.bsky.social · 24/09/2026
Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky
I am writing to let you know that, unfortunately, your application was not successful.

Review process

As part of the initial triage of the 179 proposals submitted to this call, each was assessed using an AI-based review. Every proposal was read independently by several different AI models against the same seven criteria used to shape this call (including cyber security relevance, research quality and novelty, importance of the problem addressed, feasibility of the project plan, likely outputs and impact, value for money, and responsible research practice), with each model asked to give a score and a written justification with supporting quotations from the text. To guard against any one model's idiosyncrasies, we also ran a second, independent process in which different AI models debated the merits and weaknesses of each proposal before reaching a judgement, again against the same criteria. Scores from both processes were combined to produce an overall ranking. 

This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review.  Projects selected for funding were drawn from those that progressed to the full human review stage. We recognise that AI-assisted assessment is a new and evolving part of the review process, and we are continuing to evaluate how well it aligns with the judgements of human reviewers on this call. We will soon produce a document detailing our method, so that others can build upon it and improve it.

Feedback on your application

Your application was not selected to progress beyond the AI triage stage.  To provide transparency on the outcome of this assessment, we are sharing below the scores (out of 5) from each of the two AI review processes described above, together with the mean score across the two processes.
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Alper Akay @alperakay.bsky.social · 18/09/2026
We did journal club on this paper from @nickburton.bsky.social lab and what a cool paper this is! It finds bacteria mutants that affect worm development that is caused by the accumulation of a polyamine and another screen finds the transporter in worms. www.nature.com/articles/s41...
nature.com
A noncanonical polyamine from bacteria antagonizes host mitochondrial function - Nature Communications
Polyamines produced by gut bacteria have been proposed to contribute to inflammatory bowel diseases. Here, Nauta et al. show that bacteria can produce a noncanonical polyamine intermediate that functi...
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Alper Akay @alperakay.bsky.social · 13/09/2026
Another great show by BBC Radio 4 Limelight series. This one is about AI takeover. podcasts.apple.com/gb/podcast/l...
podcasts.apple.com
Wraith: Episode 1: Breach
Podcast Episode · Limelight · 8 May · 29min
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Kirsty Grainger @kirstygrainger.bsky.social · 10/09/2026
Here is the details from UKRI (I've not yet read) www.ukri.org/news/ukri-mo...
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Paul Gardner @ppgardne.bsky.social · 23/08/2026
New paper day! What started as an overly ambitious summer student project is now published. We asked which genomic signals best distinguish protein-coding, short ncRNA and long ncRNA genes from the genomic background. doi.org/10.1093/g3jo...
doi.org
Genomic indicators of gene function: a systematic assessment of the human genome
Abstract. Proteins and non-coding RNAs are functional products of the genome that are central for crucial cellular processes. With recent technological adv
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Alper Akay @alperakay.bsky.social · 22/08/2026
People signing this either support Cofnas's racist views or are unaware of what they're endorsing 🙄. Cofnas is linked to a race science network, and many signatories are also part of it, including the Free Speech Institute and Committee for Academic Freedom… bylinetimes.com/2026/08/18/t...
bylinetimes.com
The Peter Thiel-Linked Race Science Network that Penetrated Cambridge University and Targeted Jason Arday
The media's coverage of the academic's life was fuelled by the campaign of an established far-right network
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Aparna Nair @disabilitystor1.bsky.social · 23/08/2026
not only that, they are demanding that they not be called racist when they are observed to be signing up to support the racist

Alexander Kustov
@akoustov
Do folks realize that it is not 2020 anymore and that you can't just call people you don't know or understand but seem to disagree with "racist"? 

It's just not how adults are supposed to resolve their disagreements. Cambridge is already an embarrassment. No need to add to it.
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Priyamvada Gopal ©
@PriyamvadaGopal
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11h
It is kind of charming that all the racists are outing themselves.  By racists here I mean people who appear to thing 'race science' and 'race realism' are actual disciplines because human beings are fundamentally biologically different from each other. x.com/prossertj/stat…
6:16 PM · Aug 22, 2026
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Alper Akay @alperakay.bsky.social · 23/08/2026
Has @ucu.org.uk done anything through all these voluntary redundancies to document what demographics were most affected and how this changed UCU membership? I think this would be important to document.
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Alper Akay @alperakay.bsky.social · 22/08/2026
People signing this either support Cofnas's racist views or are unaware of what they're endorsing 🙄. Cofnas is linked to a race science network, and many signatories are also part of it, including the Free Speech Institute and Committee for Academic Freedom… bylinetimes.com/2026/08/18/t...
bylinetimes.com
The Peter Thiel-Linked Race Science Network that Penetrated Cambridge University and Targeted Jason Arday
The media's coverage of the academic's life was fuelled by the campaign of an established far-right network
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T. Ryan Gregory 🇨🇦 @tryangregory.bsky.social · 15/08/2026
If you're a biologist, especially one in a field that has a history of eugenics and racism (which absolutely includes my own field of evolutionary biology) and you choose to remain "neutral" as race science once again crawls out from under its rock, you are not in fact neutral.
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EPIGENETIC HULK @epigenetichulk.bsky.social · 19/08/2026
HAHAHAHAHAHAHAHAHAHAHAHAHAHA! EPIGENETIC HULK LIKE THIS SMASH! NO SMASH NOTES! www.cell.com/cell-genomic...
cell.com
Single-cell 3D genome imaging shows super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting
Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...
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Alper Akay @alperakay.bsky.social · 19/08/2026
We are sad to say goodbye to Kasia Hencel who was one of my first PhD students and we are very happy for her because she is joining the fantastic Walhout Lab @UMass .
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Alper Akay @alperakay.bsky.social · 17/08/2026
This year we had an amazing lab day out at Gressenhall Farm & workhouse. Thanks to all lab members and our PGT students! @biouea.bsky.social
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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Alper Akay @alperakay.bsky.social · 03/06/2026
We are advertising for a fixed-term Impact Lecturer in Microbiology @biouea.bsky.social I believe what this means is that you should have evidence for developing impact such as startups, policy influence etc rather than research excellence/publications. vacancies.uea.ac.uk/vacancies/20...
vacancies.uea.ac.uk
Impact Lecturer in Microbiology (ATR1737) in University of East Anglia | UEA
View details and apply for this Impact Lecturer in Microbiology (ATR1737) vacancy in University of East Anglia. Faculty of Science School of Biological Sciences Impact Lecturer in Microbiology...
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Alper Akay @alperakay.bsky.social · 30/05/2026
This is getting absurd @ukri.org !!! @chionwurah.bsky.social @resprofnews.bsky.social @timeshighered.bsky.social
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Kirsty Grainger @kirstygrainger.bsky.social · 29/05/2026
A new TOP FIVE has just dropped. The @ukri.org TOP FIVE shortest timescales from call opening to closing. And you won't believe the winner 👀
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Alper Akay @alperakay.bsky.social · 24/05/2026
We are so lucky to have Norwich Festival. It was an amazing GoGo Penguin concert last night. Really worth watching them live.
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UEA Biological Sciences @biouea.bsky.social · 18/05/2026
Join our next BIO Open Lecture on Weds 20 May, 2-3pm, Queens Building 1.03 when we welcome Prof. Stefanie Kaiser, Goethe University Frankfurt @kaiserlab.bsky.social. Talk: "Mass spectrometry for mapping RNA modifications in human disease". Host: @alperakay.bsky.social All Welcome #UEAScience
Join us for our next BIO Open Lecture on Wednesday 20 May, 2-3pm, Queens Building 1.03 when we welcome Prof. Stefanie Kaiser from Goethe University Frankfurt with a talk title "Mass spectrometry for mapping RNA modifications in human disease". Hosted by Alper Akay, BIO. All Welcome #UEAScience
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Alper Akay @alperakay.bsky.social · 17/05/2026
We had great time attending #RiboRed2026 which was at a fantastic location north of Barcelona. There is amazing RNA research happening in Spain and looking forward to future collaborations. This was also the final conference for our postdoc Kasia before moving on to new research.
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Alper Akay @alperakay.bsky.social · 11/05/2026
www.nytimes.com/2026/05/11/o...
nytimes.com
Opinion | The Silence That Meets the Rape of Palestinians
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Elisabeth Bik @elisabethbik.bsky.social · 08/05/2026
Oh, come on, @aaas.org Science Translational Medicine, correcting a paper for a photoshopped image? That is absolutely bonkers, and you should do much, much better. #ThisImageIsFine #ImageForensics
Figure 3Ai - original on the left, corrected on the right. Both show 4 panels with 5 gelleous droplets on tissue paper. On the left image (original) i have marked two droplets in the top panel with red boxes, because they look the same.
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Alper Akay @alperakay.bsky.social · 05/05/2026
What does this actually mean for people funded by @ukri.org ? So the journal has to be fully open access, no subscription but we still pay APC? What about read and publish? www.researchprofessionalnews.com/rr-news-uk-o...
researchprofessionalnews.com
UKRI to phase out funding for hybrid open access - Research Professional News
Funder announces it will focus on supporting “fully open access publishing” from 2028-29
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Alper Akay @alperakay.bsky.social · 01/05/2026
That’s starting professorial salary in UK. I’d take it as a sabbatical! apple.news/Aj-yC_ZibTkK...
apple.news
Job posting for 'live-in dog companion' comes with an impressive £60,000 salary — Metro
This is a dream job for dog lovers!
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Alper Akay @alperakay.bsky.social · 30/04/2026
In a small poll conducted at our UKmidPI Slack channel which has 85 mid-level PIs, 88% support UK’s continued association with ERC given the current UK funding and recent changes to ERC. Turn around only 27. Wouldn’t it be great if we could poll academics on academic matters?
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Alper Akay @alperakay.bsky.social · 24/04/2026
😳😳😳 www.nature.com/articles/s41...
nature.com
Induction and regulation of reversible suspended animation in C. elegans - Nature Communications
A reversible suspended animation state in C. elegans is triggered by crowding in liquid. It reshapes gene activity, metabolism and organelles, uncovering lysosomal and neuronal signals that control su...
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Torben Heick Jensen @heick.bsky.social · 23/04/2026
Final call for postdoctoral positions in my lab in wonderful Århus. You may apply using this link: mbg.au.dk/en/news-and-...
mbg.au.dk
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
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Alper Akay @alperakay.bsky.social · 22/04/2026
According to a new study, in UK, it costs a university approx. £115k for an academic to apply for a research grant of £1m whether they get the funding or not. And the strategy of universities? Apply as many grants as you can. 🤦‍♂️🤦‍♂️https://www.researchprofessional.com/news-articles/article/1419047
researchprofessional.com
Research Professional Sign-in
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Alper Akay @alperakay.bsky.social · 20/04/2026
Last week we had a fantastic UK C. elegans 2026 meeting at the Southampton University. Massive thanks to organisers Vincent O’Connor and Lindy Holden-Dye. It’s great to see this meeting getting more popular each year. @gensocuk.bsky.social
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 20/04/2026
The LARP1 RRM functions as a ribosome responsive regulator of TOP mRNAs James A Saba, Phoebe E White, A. Maxwell Burroughs, L. Aravind, Rachel Green www.biorxiv.org/content/10.6...
biorxiv.org
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Alper Akay @alperakay.bsky.social · 19/04/2026
More evidence for TAD uncoupling from gene expression. I also like the earlier work of Furlong lab using the balancers to disrupt TADs with no correlation to gene expression changes - www.nature.com/articles/s41.... What do TADs do then?
nature.com
Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression - Nature Genetics
Systematic analysis of highly rearranged balancer chromosomes in Drosophila shows that extensive changes to chromatin topology affect the expression of only a subset of genes.
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Alper Akay @alperakay.bsky.social · 02/04/2026
When is the last time you felt you can replicate (generate the data and do analysis) a CNS paper in your lab?
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Alper Akay @alperakay.bsky.social · 26/03/2026
Deadline is 8th of April. #phdposition
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Peter Sarkies @psarkies.bsky.social · 14/03/2026
Happy pi (RNA) day everyone! And what better way to enjoy than to revisit the unusual features of nematode piRNAs: www.cell.com/developmenta...
cell.com
Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis
piRNAs are an important genome regulatory mechanism conserved across metazoans. In the nematode C. elegans, piRNA biogenesis evolved several differences from other metazoans. Beltran et al. study the ...
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Willem van Schaik @wvschaik.bsky.social · 14/03/2026
Is anyone here aware of any research into the impact (e.g. changing ranking) and effectiveness (picking the best candidates, without biases) of interviews in grant application peer review process?
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Alper Akay @alperakay.bsky.social · 14/03/2026
Buying used electric cars is already a big gamble and now the cars might not even gave the fedtures you think they have . www.theguardian.com/environment/...
theguardian.com
‘Shockingly bad’: Nissan Leaf drivers voice anger over app shutdown
Carmaker’s decision to drop NissanConnect EV app on relatively recent cars fuels warnings from experts
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Alper Akay @alperakay.bsky.social · 06/03/2026
PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...
biodtp.norwichresearchpark.ac.uk
How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership
This is open to Home Fee Status candidates only. This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA…
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Alper Akay @alperakay.bsky.social · 11/03/2026
£40m funding to setup an AI lab, expression of interest in two weeks and full application deadline in 4 weeks from advert. Can @jamesdracott.bsky.social explain why the rush? Why not give people more time? Grants costing less than £1m take easily 2-3x longer to prepare. @ukri.org
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Jordy F. Botello @jbotello.bsky.social · 10/03/2026
Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...
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mmbdtp.bsky.social @mmbdtp.bsky.social · 09/03/2026
Are you a biological sciences or bioinformatics/computing graduate with home fee status, interested in a funded #PhD starting in October? If so, look 🔽 Application deadline 8 April 2026 www.uea.ac.uk/course/phd-d...
uea.ac.uk
PhD How do plastics impact bacterial pathogens in food waste (CLARKE_U26MMBiCASE) 2026/27 | UEA
PhD How do plastics impact bacterial pathogens in food waste (CLARKE_U26MMBiCASE) 2026/27 | UEA
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Alper Akay @alperakay.bsky.social · 07/03/2026
We are seeing a large number of papers being published on new AI models in biology, disease, genomics. What should we look for in these papers before committing our time to test their use? I really wonder how they are reviewed as well.
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Alper Akay @alperakay.bsky.social · 07/03/2026
This is ridiculous but not surprising! Obviously, EPSRC must have people/organisations in mind and I wouldn’t be surprised if they have been in contact with some groups in advance. Some hard questions about why £40m is spent as such www.researchprofessionalnews.com/rr-news-uk-r...
researchprofessionalnews.com
Four-week timeframe for £40m AI research lab divides opinion - Research Professional News
Tech advocates celebrate prospect of new UK lab, but “extremely tight” application window sparks concern
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Nucleic Acids Research @narjournal.bsky.social · 06/03/2026
⭐ #NARBreakthrough! ⭐ 🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨ Read the full article here: doi.org/10.1093/nar/... #AlternativeSplicing
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Alper Akay @alperakay.bsky.social · 06/03/2026
PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...
biodtp.norwichresearchpark.ac.uk
How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership
This is open to Home Fee Status candidates only. This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA…
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Faraz Mardakheh @handle.invalid · 21/02/2026
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP
nature.com
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
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Alper Akay @alperakay.bsky.social · 22/02/2026
I hope people of Gorton & Denton vote for a party that stands up for humanity and against genocide. Don’t believe in the lies of many politicians claiming they care about you while turning a blind eye to worst crimes of humanity of our times. apple.news/ATgPSimpARKC...
apple.news
In Gorton & Denton, voters all feel they have been left behind — The Times and The Sunday Times
There is a forgotten generation of white British voters. They feel sidelined. Confused. Swamped by mass immigration they didn’t vote for; bewildered at being told they enjoy “white privilege” while li...
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Alper Akay @alperakay.bsky.social · 22/02/2026
www.dw.com/en/no-reckon...
dw.com
No reckoning over ethnic cleansing of Bulgaria's Turks
Bulgaria's Turkish community, descendants of Ottoman settlers, suffered severe persecution under the communist regime. Yet little has been done to address the injustice.
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Alper Akay @alperakay.bsky.social · 21/02/2026
I suppose if you are still organising an “international” conference in the US, you are effectively helping ICE. apple.news/AgpcB41ERTmu...
apple.news
‘Don’t go to the US – not with Trump in charge’: the UK tourist with a valid visa detained by ICE for six weeks — The Guardian
Karen Newton was in America on the trip of a lifetime when she was shackled, transported and held for weeks on end. With tourism to the US under increasing strain, she says, ‘If it can happen to me, i...
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