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Trials of drugs to fight deadly resistant infections are advancing, but they might fall victim to overuse of agricultural fungicides just like their predecessors.

This study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulner...

An international team of researchers has identified an East African bat coronavirus capable of entering human cells.

Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.

The molecular mechanisms allowing organisms to adapt to new telomeric sequences remain poorly understood. Here, the authors engineer multiple yeast lines with human-like telomeric repeats to unveil th...

Abstract. Multicellular fungi have repeatedly given rise to primarily unicellular yeast species. Some of these, including the fission yeast Schizosaccharom

We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

PhD Project - Proteomic Signatures of Treatment Response During Pulmonary Exacerbations in Cystic Fibrosis at University of Liverpool, listed on FindAPhD.com

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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

From floods to extreme temperatures, climate impacts risk damaging homes, health, businesses, services, and the economy. We want Government to prioritise adaptation; fund a new Resilience Plan that wo...

Protein phosphatase 1 (PP1) is a key regulator of cellular phosphorylation and its activity is regulated via binding to cellular regulatory proteins via conserved short linear motifs (SLiMs). The herp...

ALT: a cat sitting on a couch using a laptop with the word research written on the screen

Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...

Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...