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Yasu Daigaku

@yasudaigaku.bsky.social

66 followers 28 following 5 posts

Scientist, Field: DNA replication, Mutagenesis, Genome stability

Posts Replies Media

Yasu Daigaku @yasudaigaku.bsky.social · 09/03/2026

I have been thinking about how to make our genomic data easily accessible to the public, and I am now testing Amazon Web Services. On this server, I have set up JBrowse (a type of genome browser) with datasets from human Polymerase usage sequencing (Pu-seq, Koyanagi et al Nat Commun 2022).

cgd-daigaku-lab.s3.ap-northeast-1.amazonaws.com

JBrowse

A fast and flexible genome browser

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Yasu Daigaku @yasudaigaku.bsky.social · 09/03/2026

The collaboration with the Taka Nojima lab (Kyushu University) and the Michael Tellier lab (University of Leicester) was published in EMBO Reports! We contributed to this work by analysing the effect of transcription termination defects on DNA replication. link.springer.com/article/10.1...

link.springer.com

NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports

Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...

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Yasu Daigaku @yasudaigaku.bsky.social · 12/09/2025

Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis. www.biorxiv.org/content/10.1...

biorxiv.org

Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis.

Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (P...

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Yasu Daigaku @yasudaigaku.bsky.social · 27/11/2024

Thanks to Gideon @costerlab.bsky.social for visiting JFCR and for a very inspiring seminar. We learned a lot about the impact of many DNA structures on genome replication/stability!

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