Sign in

Louise H. Moncla

@lhmoncla.bsky.social
4.6K followers 164 following 133 posts

Assistant Professor of Pathobiology at the University of Pennsylvania. We use trees to study RNA virus evolution and transmission, with a focus on avian influenza. viruses, sequencing, phylogenetics, pop gen. She/her lmoncla.github.io/monclalab

PostsRepliesMedia
Louise H. Moncla @lhmoncla.bsky.social · 28/09/2026
Due to some really great work from the @nextstrain.org team, it is now easier to put together new builds! We've recently released H7Nx and H10Nx builds onto the main avian-flu page along with all the standard features. Check them out! nextstrain.org/avian-flu/h1...
nextstrain.org
auspice
133
Reposted by Louise H. Moncla
IDDjobs @iddjobs.org · 25/09/2026
Postdoc (London, UK) Develop new methods for pathogen genomic epidemiology with @ceciletk.bsky.social at Imperial College London @mrc-outbreak.bsky.social More details: iddjobs.org/jobs/2596
025
Louise H. Moncla @lhmoncla.bsky.social · 23/09/2026
Our lab just put out a new preprint! Led by Maria Maltepes, we've been working with @tavisanderson.bsky.social and @alexey-markin.bsky.social to understand how host species impacts the fundamentals of how influenza viruses evolve. TLDR, reassortment and selection rates vary widely across species.
scholar.google.com
12215
Louise H. Moncla @lhmoncla.bsky.social · 25/08/2026
Which virology journals have a quick submit to review/editorial reject decision? We've had two papers sit at journals for > a month and then be editorially rejected, and are trying to find journals that will at least reject quickly. We are not shooting for the stars, just reasonable journals
010
Reposted by Louise H. Moncla
nitanother.bsky.social @nitanother.bsky.social · 17/08/2026
We're hiring multiple post docs to work on spatial and quantitative models of infectious disease! For details and application materials: psu.wd1.myworkdayjobs.com/PSU_Academic... and see our lab website here: humidlab.com
psu.wd1.myworkdayjobs.com
Postdoctoral Scholar - Bharti Lab
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
025
Reposted by Louise H. Moncla
Ed Hutchinson @socialinfluenza.bsky.social · 23/07/2026
🚨New Pre-Print!🚨 Want to search for variation in influenza A virus sequences, but find the amount of data overwhelming? Wondering if new avian flu strains have signs of mammalian adaptation? The #Flu-MutationExplorer, a new online tool, can help (1/n) www.biorxiv.org/content/10.6...
An image in the style of an Andy Warhol screen print showing influenza virions in a variety of colours. (Image credit Ed Hutchinson and Naina Nair, MRC-University of Glasgow Centre for Virus Research)
23115
Louise H. Moncla @lhmoncla.bsky.social · 23/07/2026
Led by Anna Jaeger and Elena Cruz-Adames, we have a new preprint out on within-sample diversity and local spread of H5N1 in Pennsylvania! www.biorxiv.org/content/10.6.... We developed a sequencing protocol and bioinformatic pipeline to sequence residual RNA from H5+ wild and domestic birds in PA.
biorxiv.org
Within- and between-host dynamics of highly pathogenic avian influenza in domestic birds from Pennsylvania farms and live bird markets
Since late 2021, highly pathogenic avian influenza viruses (HPAI) of the H5 subtype clade 2.3.4.4b have spread across the Americas, devastating wildlife, agricultural animals, and resulting in dozens ...
1157
Louise H. Moncla @lhmoncla.bsky.social · 13/07/2026
As a young PI, it can feel like everything is out of our control. But today, we used our lab meeting to have each person draft and submit comments on the OMB rule. It felt really good to prioritize this within the work day for our lab, and it felt more empowering to do it as a group.
171
Reposted by Louise H. Moncla
Hensley Lab @scottehensley.bsky.social · 05/07/2026
Do you live in Philly? Has your cat been acting crazy? Well, it is likely this craziness is not due to H5N1 infection--but rather the fact that your cat is a cat. In this new preprint with @lhmoncla.bsky.social we find low H5N1 seroprevalence rates in Philly cats. www.biorxiv.org/content/10.6...
biorxiv.org
Clade 2.3.4.4b H5N1 influenza virus and SARS-CoV-2 seroprevalence among owned and feral cats in Philadelphia and surrounding communities
Clade 2.3.4.4b H5NX influenza viruses have spread widely in birds since 2020. In addition to causing disease in birds, these viruses have infected a variety of mammals, including humans. Clade 2.3.4.4...
1175
Reposted by Louise H. Moncla
Chris Brooke @christopherbrooke.bsky.social · 14/05/2026
Excited to announce that we are moving the lab to Minneapolis to join the University of Minnesota Department of Microbiology & Immunology and Institute on Infectious Diseases this summer!! We will be hiring so please reach out if interested in viral evolution, viral immunology, etc.!!
Sunset view of the Mississippi river and beautiful downtown Minneapolis
95013
Reposted by Louise H. Moncla
Gytis Dudas @evogytis.bsky.social · 22/04/2026
Please share! My lab has an open fully-funded PhD position at Vilnius University's Life Sciences Center in Lithuania. The PhD project will involve identifying missing orthomyxovirus segments from public sequence data. Applicants must hold an MSc by June & have bioinformatics experience. 1/2
11720
Louise H. Moncla @lhmoncla.bsky.social · 20/04/2026
In collaboration with Nicola Muller, and led by @lambod50.bsky.social, we have a new preprint out that's all about reassortment! www.biorxiv.org/content/10.6... Using TargetedBeast, we built massive (9000 tips!) Bayesian phylogenies of North American H5Nx viruses, and inferred the host...
biorxiv.org
12310
Reposted by Louise H. Moncla
Ed Hutchinson @socialinfluenza.bsky.social · 05/03/2026
🚨New Influenza Tool🚨 Interested in IAV mutations? Looking for markers of mammalian adaptation? Frustrated by converting between IAV numbering systems? The #Flu-MutationExplorer, a new tool from @cvrbioinfo.bsky.social and @royalvetcollege.bsky.social, is here to help: flu-gdb.cvr.gla.ac.uk (1/n)
A 3x3 grid of coloured images of influenza virus particles in the style of an Andy Warhol screen print. Image credit Naina Nair / Ed Hutchinson (MRC-University of Glasgow Centre for Virus Research)
23019
Louise H. Moncla @lhmoncla.bsky.social · 02/03/2026
Big news for those of us clicking around on trees all the time!
020
Louise H. Moncla @lhmoncla.bsky.social · 11/02/2026
Cool opportunity to work on avian flu with a great team! lnu.se/en/meet-linn...
lnu.se
Vacancies page
010
Reposted by Louise H. Moncla
Dr Emma Hodcroft @firefoxx66.bsky.social · 20/11/2025
1/ 🚀 Exciting news: we’ve just released the first Nextclade dataset for Enterovirus D68 (EV-D68), developed in collaboration with the European Non-Polio Enterovirus Network (ENPEN). 👉🏻 Check out the dataset on Nextclade! clades.nextstrain.org?dataset-name... #EVD68 #Enterovirus #OpenData
15316
Louise H. Moncla @lhmoncla.bsky.social · 19/11/2025
Last week, a human in Washington was hospitalized for H5N5, the first human case of highly pathogenic H5N5 in the US. doh.wa.gov/newsroom/h5n.... Thanks to work from Anna Jaeger and Stephen Shank in our lab, we've added this strain to our North American phylogeny: nextstrain.org/groups/moncl...
25613
Louise H. Moncla @lhmoncla.bsky.social · 12/11/2025
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
nature.com
Ecology and spread of the North American H5N1 epizootic - Nature
The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...
614065
Louise H. Moncla @lhmoncla.bsky.social · 15/10/2025
Our lab's first paper is out! Led by Jordan Ort, we developed NextClade datasets that enable rapid H5 clade assignment via NextClade. We deployed these during the start of the H5 cattle outbreak, and we finally published the paper in Virus Evolution academic.oup.com/ve/article/1...
academic.oup.com
Development of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment
Abstract. The 2022 panzootic of highly pathogenic avian influenza (HPAI) A(H5) viruses has led to unprecedented transmission to multiple mammalian species.
33912
Louise H. Moncla @lhmoncla.bsky.social · 14/08/2025
I've always loved Ted Chiang and his writing
070
Reposted by Louise H. Moncla
Alexey Markin @alexey-markin.bsky.social · 11/08/2025
TreeSort is out at MBE! Fresh off the press so DOI below is not yet working, but you can find the article here: academic.oup.com/mbe/article/... 💡If you want to apply it to your data - please see the tutorial here github.com/flu-crew/Tre...
academic.oup.com
Revealing Reassortment in Influenza A Viruses with TreeSort
Abstract. Reassortment among influenza A viruses (IAV) facilitates evolution and has been associated with interspecies transmission and pandemics. We intro
163
Louise H. Moncla @lhmoncla.bsky.social · 25/07/2025
Emma is great, and leading the way on making better ways to share and aggreggate data. This is an awesome opportunity!!
050
Reposted by Louise H. Moncla
Katherine Xue @ksxue.bsky.social · 17/07/2025
The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more. recruit.ap.uci.edu/JPF09601
recruit.ap.uci.edu
Junior, Assistant, or Associate Specialist – Xue Lab
University of California, Irvine is hiring. Apply now!
0117112
Reposted by Louise H. Moncla
Gregg Gonsalves @gregggonsalves.bsky.social · 09/06/2025
This is incredibly courageous and brave. Support NIH staffers. They stuck out their necks for us. Now we have to have their backs.
017266
Louise H. Moncla @lhmoncla.bsky.social · 19/03/2025
This is so useful! Very good to know that someone is looking
070
Reposted by Louise H. Moncla
Erik Karlsson @eakarlsson.bsky.social · 25/02/2025
The Virology Unit at IPC has 3 positions open in #OneHealth: *Postdoc – Reconstructing Past Outbreaks *Postdoc – Environmental Surveillance *Clinical Manager These aren’t just jobs. They’re front-row seats to global health in action. Ready? tinyurl.com/57rvxcau #ViroSky #IDSky 🦠🔬🧬🥼🧪
tinyurl.com
Institut Pasteur du Cambodge on LinkedIn: The Institut Pasteur du Cambodge (IPC) is looking for: -…
The Institut Pasteur du Cambodge (IPC) is looking for: - 𝐏𝐨𝐬𝐭𝐝𝐨𝐜𝐭𝐨𝐫𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫 – 𝐒𝐞𝐫𝐨𝐥𝐨𝐠𝐲 𝐚𝐭 𝐭𝐡𝐞 𝐇𝐮𝐦𝐚𝐧-𝐀𝐧𝐢𝐦𝐚𝐥…
0810
Louise H. Moncla @lhmoncla.bsky.social · 28/02/2025
This week @scottehensley.bsky.social and I briefed the Pennsylvania state House Agriculture and Rural Affairs and Health committees on H5N1. It was super interesting and useful, and we got some great questions. www.youtube.com/live/yRxdeG9..., we got one question that I would like to crowd source:
youtube.com
YouTube
Share your videos with friends, family, and the world
1142
Louise H. Moncla @lhmoncla.bsky.social · 24/02/2025
Has anyone ever been to a MEEGID meeting, and if so, what did you think? www.elsevier.com/events/confe...
elsevier.com
Meegid XVII | Elsevier
17th International Conference on Molecular Epidemiology and Evolutional Genetics of Infectious Diseases
110
Louise H. Moncla @lhmoncla.bsky.social · 24/02/2025
Really lovely work here lead by Janathan Pekar, @worobey.bsky.social @peacockflu.bsky.social @influenzal.bsky.social and many others.
150
Reposted by Louise H. Moncla
Thijs Kuiken @thijskuiken.bsky.social · 17/02/2025
What is happening in the USA, including U.S. government censorship of research, is unacceptable. The least we can do is to state our opposition publicly. Please have a look at this declaration and--if you agree--put your name to it. docs.google.com/document/u/0...
docs.google.com
Declaration To Defend Research Against Government Censorship
Declaration To Defend Research Against U.S. Government Censorship, V.1.1 Drafted by Lisa Schiff (@lschiff.bsky.social), Alice Meadows (@alicemeadows.bsky.social), Catherine Mitchell (@camitchell.bsky....
01411
Reposted by Louise H. Moncla
American Society for Virology @amersocvirology.bsky.social · 13/02/2025
Dear Virology Community, please see ASV’s statement to our members and the scientific community. asv.org/asv-statemen...
asv.org
ASV Statement for our Members | American Society for Virology
Our American Society for Virology (ASV) promotes the study and combatting of viruses, more than ever recognizing their importance and responding to them with research and education. Our academic…
16432
Louise H. Moncla @lhmoncla.bsky.social · 13/02/2025
It made me so happy to see that MMWR is back!
090
Louise H. Moncla @lhmoncla.bsky.social · 05/02/2025
I agree with Scott. This is important because: 1. This shows that cattle are susceptible to other H5N1 viruses, not just B3.13. 2. D1.1 viruses are currently transmitting really efficiently through wild birds in North America, and are very widespread. ...
44324
Reposted by Louise H. Moncla
Shenglai @shenglai.bsky.social · 03/02/2025
Our next #IFEEAI webinar speaker is @lhmoncla.bsky.social , Assistant Professor @upenn.edu Title: Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of #H5N1 #birdflu into agriculture in North America.
284
Reposted by Louise H. Moncla
Dave Levitan @davelevitan.bsky.social · 28/01/2025
Per an NIH source: “Discussions with colleagues have suggested that if the universities all come together and raise hell about the delays to funding caused by not holding meetings, that might move the needle. From every state. There are well-funded universities in red states that will be impacted.”
268145183342
Louise H. Moncla @lhmoncla.bsky.social · 28/01/2025
Call your senators! Do it today! It's better than wallowing
0145
Louise H. Moncla @lhmoncla.bsky.social · 10/01/2025
Our lab's 2nd preprint is now on bioRxiv! Led by Jordan Ort, we made H5 datasets that enable rapid clade assignment with Nextclade. We released these builds in the spring (due to cow flu) & finally wrote the paper! TLDR: it's fast, easy, accurate, and we hope, useful www.biorxiv.org/content/10.1...
biorxiv.org
Development of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment
The ongoing panzootic of highly pathogenic avian influenza (HPAI) A(H5) viruses is the largest in history, with unprecedented transmission to multiple mammalian species. Avian influenza A viruses of t...
36115
Louise H. Moncla @lhmoncla.bsky.social · 10/01/2025
I'm co-organizing a symposium and we are looking for people who do cool work on infectious disease and climate change! Who is doing cool stuff in that space?
483
Reposted by Louise H. Moncla
Tom Peacock @peacockflu.bsky.social · 07/01/2025
Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
biorxiv.org
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...
9349157
Reposted by Louise H. Moncla
Lambodhar Damodaran @lambod50.bsky.social · 20/12/2024
Really excited to share that my postdoctoral work on HPAI in North America is now preprinted! Please feel free to reach out with any feedback and thoughts! www.biorxiv.org/content/10.1...
biorxiv.org
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America
Since late 2021, a panzootic of highly pathogenic H5N1 avian influenza virus has driven significant morbidity and mortality in wild birds, domestic poultry, and mammals. In North America, infections i...
1237
Louise H. Moncla @lhmoncla.bsky.social · 20/12/2024
Just in time for the holidays, our lab has just submitted our first lab led paper www.biorxiv.org/content/10.1...! We use phylodynamics to reconstruct how H5N1 got to North America and spread so rapidly. Full thread coming post holidays, but for now, super proud of @lambod50.bsky.social
biorxiv.org
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America
Since late 2021, a panzootic of highly pathogenic H5N1 avian influenza virus has driven significant morbidity and mortality in wild birds, domestic poultry, and mammals. In North America, infections i...
614145
Reposted by Louise H. Moncla
Jessica Metcalf @jessmetcalf.bsky.social · 09/12/2024
Senior Postdoctoral Research position open in EEB Princeton puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu
01117
Reposted by Louise H. Moncla
Kai Kupferschmidt @kakape.bsky.social · 06/12/2024
If an #H5N1 pandemic starts tomorrow or in three months, there will be little mystery as to how it happened. The conditions are all there. They have been for a while. So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet? Story here, 🧵 to come: 🧪#IDSky
science.org
Why hasn’t the bird flu pandemic started?
Some scientists examining mutations found in H5N1 viruses fear major outbreak is imminent but others says pathogen remains unpredictable
641417671
Louise H. Moncla @lhmoncla.bsky.social · 25/11/2024
This truly makes me queasy. I really hope no one drinks this milk
070
Louise H. Moncla @lhmoncla.bsky.social · 17/11/2024
Additional information from Scott and Jesse
060
Louise H. Moncla @lhmoncla.bsky.social · 17/11/2024
Last week, a teenager in British Columbia contracted H5N1, the first human case acquired in Canada. The BC CDC and and Canadian Food Inspection Agency have released sequences from this infected person and domestic and wild birds sampled in BC, which we've just added to Nextstrain. A thread:
nextstrain.org
auspice
710450
Louise H. Moncla @lhmoncla.bsky.social · 14/05/2024
New tool announcement! Thanks to a lot of work from Jordan Ort (an awesome student in the lab), with help from @richardneher , Todd Davis, Tommy Lam, and Sam Shepard, the H5s are now on Nextclade! clades.nextstrain.org A thread below:
141
Reposted by Louise H. Moncla
Kristian G. Andersen @kgandersen.bsky.social · 03/05/2024
Preliminary report on genomic epidemiology of the 2024 H5N1 influenza A virus outbreak in U.S. cattle. Thanks to everyone who contributed to this and, of course, first and foremost the data producers and those involved in the response. virological.org/t/preliminar...
virological.org
Preliminary report on genomic epidemiology of the 2024 H5N1 influenza A virus outbreak in U.S. cattle (Part 1 of 2)
Due to length constraints on virological.org posts, we are splitting this report into two parts that should be read as a single report. This is Part 1, containing Background, Data, Methods, and Findi...
23418
Louise H. Moncla @lhmoncla.bsky.social · 01/04/2024
In response to the H5N1 infections in cows and now a human in Texas, we've just updated our North America specific H5Nx Nextstrain build with the cow and goat sequences, which are viewable under "Species-grouped: Ruminant": nextstrain.org/groups/moncl.... A few notes.
nextstrain.org
auspice
176
Louise H. Moncla @lhmoncla.bsky.social · 25/03/2024
Such a great resource, and wonderful to see this in print! Can recommend for anyone getting into genomic epidemiology.
010