All the countries and cities taking part in Pint of Science 2026 (#pint26) 18-20 May 2026 See pintofscience.com for more information.

We have investigated changes in chromosome conformation, nuclear organization, and transcription during differentiation and maturation of control and mutant motor neurons harboring hexanucleotide expa...

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...

How transcription and cohesin complexes interact to regulate 3D genome organization remains unclear. Chapard et al. dissect their respective contributions and their interplay in shaping the genome arc...

Quand notre ADN se casse, nos cellules le réparent avec une haute précision.

A CNRS Junior Professorship on RNA Modifications and Advanced Epitranscriptomic Technologies offer at CBI-Toulouse Fixed-term (3–6 years), tenure-track (Chaire de Professeur Junior) Application Dead...

Pint of Science provoque LA rencontre entre scientifiques et grand public et lève le voile sur les découvertes et les avancées scientifiques et technologiques. Parce que non, dans un labo ça ne se pas...

Nature Reviews Genetics - Barbadilla-Martínez et al. review recent progress in deep-learning-based sequence-to-expression models, which predict gene expression levels solely from DNA sequence....

A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between t...

YouTube video by Johan Gibcus

Synthetic biologists have the know-how and ambition to retool whole genomes. But the hidden complexity of biological systems continues to surprise them.

The critical events in transcription termination of RNA polymerase II (Pol II) remain not fully understood. Here, the authors find that the transcription factor Spt5 enhances the activity of RNA exonu...

Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...