Peroxiredoxin 1 (PRDX1) is a highly conserved, thiol-dependent peroxidase that rapidly scavenges reactive oxygen species to modulate redox signaling. PRDX1-null mice exhibited genomic instability, sho...

Eduard Strasburger-Workshop: From young plant scientits for young plant scientists exclusively - supported by the DBG

Plasmid pRSETb 6xHis-Cystector (Cysteine biosensor) from Dr. Peter Dedecker's lab contains the insert Cystector (Cysteine biosensor) and is published in bioRxiv 2026.01.27.698081 This plasmid is avai...

Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

Accurate measurement of cysteine and related thiol-containing metabolites is essential for understanding cellular redox regulation. However, the intrinsic reactivity and instability of cysteine presen...

Cancer cells undergo changes in metabolism that distinguish them from non-malignant tissue. These may provide a growth advantage by promoting oncogenic signaling and redirecting intermediates to anabolic pathways that provide building blocks for new cellular components. Cancer metabolism is far from …

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

17th International Conference on Reactive Oxygen and Nitrogen Species in Plants

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This Review discusses the intricate relationship between metabolism and embryogenesis, highlighting the orchestration of key developmental processes by metabolites and signalling molecules that provid...

ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase contro...

Thiol-based redox transcription factor pathways play central roles in the cellular response to peroxide stress. We review the bacterial OxyR, yeast AP-1 and mammalian NRF2/Keap1 systems and the princi...

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research has surged, the intracellular site for ferroptosis initiation remains uncertain....

Marie Skłodowska-Curie Fellowships: Call for Expressions of Interest 2025

Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finel…

Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, report...

Redox reactions have been essential for the emergence of life on Earth, and diverse strategies have evolved for responding to various cellular redox species. These mechanisms are still of vital impor…