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Brandán Pedre

@brandanium.bsky.social
996 followers 338 following 17 posts

I make fluorescent indicators that monitor metabolites and signaling molecules in the cell. Now @KULeuven, previously in @DKFZ and @VIBLifeSciences.

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Reposted by Brandán Pedre
Luke Lavis @rhodamine110.bsky.social · 15/04/2026
Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...
nature.com
A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods
A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...
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Reposted by Brandán Pedre
Joachim Goedhart @joachimgoedhart.bsky.social · 13/04/2026
📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...
Image of a calcium calibration curve, calcium concentration traces of individual cells and lifetime images of cells
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Reposted by Brandán Pedre
Addgene @addgene.bsky.social · 30/03/2026
Cystector plasmids now available!
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Brandán Pedre @brandanium.bsky.social · 30/03/2026
Want to monitor cysteine dynamics in real time and with subcellular resolution? Cystector plasmids are now on Addgene! E. coli (His-tagged): addgene.org/250652/ Mammalian cells: addgene.org/250653/ Yeast: addgene.org/250654/ Yeast mitochondrial: addgene.org/250655/ Preprint: doi.org/10.64898/202...
addgene.org
Addgene: pRSETb 6xHis-Cystector (Cysteine biosensor)
Plasmid pRSETb 6xHis-Cystector (Cysteine biosensor) from Dr. Peter Dedecker's lab contains the insert Cystector (Cysteine biosensor) and is published in bioRxiv 2026.01.27.698081 This plasmid is avai...
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Reposted by Brandán Pedre
CNRS Biologie @cnrsbiologie.bsky.social · 16/03/2026
🧫 Et si la science devenait une œuvre d’art ? Au @museeorsay.bsky.social, des images de cellules observées au microscope deviennent une performance visuelle pour faire sortir la biologie du laboratoire et révéler l’architecture du vivant. 🎥 www.youtube.com/watch?v=TNQM...
youtube.com
Les cellules s'exposent au Musée d'Orsay | Reportage CNRS
YouTube video by CNRS
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Brandán Pedre @brandanium.bsky.social · 09/02/2026
🧪🧬 New preprint! What if the same biosensor could reveal how cysteine is regulated across life domains? We introduce Cystector, a genetically encoded fluorescent biosensor for real-time cysteine monitoring in living cells. www.biorxiv.org/content/10.6... 🧵A thread ⬇️
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Reposted by Brandán Pedre
Giulia Bertolin @bertolingiulia.bsky.social · 13/10/2025
Excited to share our #BioSenSRRF preprint on bioRxiv! 🎉 We show how SRRF microscopy can be used with FRET-based biosensors to 🔬mitochondrial functions with high resolution 😍. Code and test data are open (GitHub + Zenodo). 👏 to Nicolas, Pierre-Jean, and co-authors! www.biorxiv.org/content/10.1...
biorxiv.org
Combining FRET and super-resolution microscopy reveals kinase activation and mitochondrial activity at the nanoscale
Protein kinases are key regulators of intracellular signaling, showing activities in specific subcellular compartments and in micro- or nano-domains. Genetically encoded biosensors based on Förster′s ...
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Brandán Pedre @brandanium.bsky.social · 22/09/2025
Just wrapped up a fantastic week at the EMBO Workshop on Thiol-Based Redox Switches. Great science, great discussions, and a truly inspiring community. Huge thanks to the organizers @danareichmann.bsky.social and Tobias Dansen for their hard work in putting together such a memorable meeting!
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Reposted by Brandán Pedre
Dana Reichmann @danareichmann.bsky.social · 19/05/2025
The @EMBO workshop #EMBOthiolSwitches is coming up soon, join us in beautiful Sant Feliu de Guíxols, Spain, 13–18 September 2025! We have a fantastic speaker lineup, with a few spots still open for short talks. Abstract deadline extended to 31 May 2025. meetings.embo.org/event/25-thi...
meetings.embo.org
Thiol-based redox switches: From chemistry to physiology and pathology
Redox reactions have been essential for the emergence of life on Earth, and diverse strategies have evolved for responding to various cellular redox species. These mechanisms are still of vital impor…
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Reposted by Brandán Pedre
Michalis Nikolaidis @mg-nikolaidis.bsky.social · 23/04/2025
James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress
Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...
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Reposted by Brandán Pedre
jihwanjameslee.bsky.social @jihwanjameslee.bsky.social · 09/04/2025
🧵 1/6 Just dropped in @naturecomms.bsky.social We’ve engineered the most photostable yellow fluorescent proteins (YFPs) to date—mGold2s and mGold2t—with up to 25× greater photostability than mVenus and mCitrine, without compromising brightness. 👇 🔗 www.nature.com/articles/s41...
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Reposted by Brandán Pedre
Marc Zimmer @lightupscience.bsky.social · 18/04/2025
A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging | Science Advances www.science.org/doi/10.1126/...
science.org
A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging
Bright and photostable monomeric fluorescent proteins enable long-term time-lapse imaging in E. coli.
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Reposted by Brandán Pedre
Hana Valenta @hanavalenta.bsky.social · 18/04/2025
The most-cited papers of the twenty-first century ...and the reflection of the capricious citation culture: 🤖 www.nature.com/articles/d41...
nature.com
Exclusive: the most-cited papers of the twenty-first century
A Nature analysis reveals the 25 highest-cited papers published this century and explores why they are breaking records.
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Reposted by Brandán Pedre
Ben Long @botbml.bsky.social · 24/03/2025
touché. academic.oup.com/brain/articl...
academic.oup.com
On the responsibilities of intellectuals and the rise of bullshit jobs in universities
You may never have considered yourself to be one. Why would you? But if you’re reading this, there is more than a likelihood that you are one. If you’re a
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Brandán Pedre @brandanium.bsky.social · 25/02/2025
A long but fruitful journey: from a roGFP2-based drug screen to reaching protein targets of the proton pump inhibitor rabeprazole. Congratulations to all the authors! @aubrykmiller.bsky.social
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Reposted by Brandán Pedre
piatkevich.bsky.social @piatkevich.bsky.social · 18/02/2025
We are very excited to see the first orange flame lit up for our plasmid pHybrid-Electra2 on Addgene, which is designed for gene expression in E. coli and mammalian cells www.nature.com/articles/s41...
nature.com
Dual-expression system for blue fluorescent protein optimization - Scientific Reports
Scientific Reports - Dual-expression system for blue fluorescent protein optimization
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Brandán Pedre @brandanium.bsky.social · 31/01/2025
First Bluesky post! 👋 I work designing fluorescent indicators for redox biology. Last year, I published a review on genetically-encoded redox biosensors—DM me if you’d like a copy! Happy to connect with fluorescence enthusiasts and redox biologists. #FluorescenceFriday doi.org/10.1016/j.ab...
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Reposted by Brandán Pedre
Antonio Martínez Ruiz @tonnomartinez.bsky.social · 16/12/2024
Do you want to work as a #postdoc in our group in a Hospital Research Institute in Madrid?🏥🔬 Interested in how #mitochondria and #redox signalling/stress can influence #stroke outcome and #inflammation?🧠💊 Apply up to 26 December at n9.cl/iunkw (ref 72/2024) Full call n9.cl/gijjd Please repost 😉
Postdoctoral position in the group of Dr. Antonio Martínez Ruiz in Madrid
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