This Review examines the chemical complexity of selenium biology and the tools available to study it. Defining current limitations in detecting selenium species outlines pathways toward a more precise...

Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

YouTube video by Alzheimer Forschung Initiative

<h3>Was wird erforscht?</h3> <p>Alzheimer ist die häufigste Form der Demenz und betrifft weltweit mehrere Millionen Menschen. Wie die Krankheit entsteht, ist bislang nicht vollständig geklärt. Neueste...

Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Check out their lectures at the annual meeting in March in the Washington, D.C., metro area.

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

Postdoctoral Research Fellow - Jones Lab Chemistry job

Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finel…

Helmholtz Munich, is a member of the Helmholtz Association of German Research Centres

Biochemiker verstärkt Akademie-Institut für KI in der Biomedizin +++ ÖAW-Präsident Faßmann: „AITHYRA schon jetzt Anziehungspunkt für exzellente Forschende“

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Biochemiker verstärkt Akademie-Institut für KI in der Biomedizin +++ ÖAW-Präsident Faßmann: „AITHYRA schon jetzt Anziehungspunkt für exzellente Forschende“

Matthias Tschöp folgt im Oktober 2025 auf Bernd Huber, der seit 2002 an der Spitze der LMU steht.

HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.

Mapping transcription start sites across five mammalian species before, during, and after embryonic genome activation unveils widespread transposable element-driven transcription and co-option of evol...

Human brain organoids are plagued by heterogeneity and poor reproducibility, critical parameters for reliable disease modeling and drug testing. Here, the authors report on Hi-Q organoids which solve ...

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...

Human brain organoids are plagued by heterogeneity and poor reproducibility, critical parameters for reliable disease modeling and drug testing. Here, the authors report on Hi-Q organoids which solve ...